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Published: Sep, 2014 | Pages:
86 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Venous Thromboembolism - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Venous Thromboembolism - Pipeline Review, H2 2014', provides an overview of the Venous Thromboembolism's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Venous Thromboembolism, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Venous Thromboembolism and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Venous Thromboembolism - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Venous Thromboembolism and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Venous Thromboembolism products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Venous Thromboembolism pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Venous Thromboembolism - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Venous Thromboembolism pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Venous Thromboembolism Overview 7 Therapeutics Development 8 Pipeline Products for Venous Thromboembolism - Overview 8 Pipeline Products for Venous Thromboembolism - Comparative Analysis 9 Venous Thromboembolism - Therapeutics under Development by Companies 10 Venous Thromboembolism - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Early Stage Products 14 Venous Thromboembolism - Products under Development by Companies 15 Venous Thromboembolism - Companies Involved in Therapeutics Development 16 Sanofi 16 Isis Pharmaceuticals, Inc. 17 Daiichi Sankyo Company, Limited 18 Bayer AG 19 Portola Pharmaceuticals, Inc. 20 Green Cross Corporation 21 Regado Biosciences, Inc. 22 GlycoMimetics, Inc. 23 Gamma Therapeutics, Inc. 24 Venous Thromboembolism - Therapeutics Assessment 25 Assessment by Monotherapy Products 25 Assessment by Target 26 Assessment by Mechanism of Action 28 Assessment by Route of Administration 30 Assessment by Molecule Type 32 Drug Profiles 34 edoxaban tosylate - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 rivaroxaban - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 semuloparin - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 betrixaban - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 rivaroxaban - Drug Profile 43 Product Description 43 Mechanism of Action 43 R&D Progress 43 ISIS-FXIRx - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 REG-2 - Drug Profile 48 Product Description 48 Mechanism of Action 48 R&D Progress 48 GCC-2107 - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 GMI-1271 - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 Gammarin - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 Lysimab - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 Venous Thromboembolism - Recent Pipeline Updates 54 Venous Thromboembolism - Dormant Projects 71 Venous Thromboembolism - Discontinued Products 72 Venous Thromboembolism - Product Development Milestones 73 Featured News & Press Releases 73 Aug 30, 2014: Secondary Analysis of AMPLIFY-EXT Examining Predictors of Hospitalization Presented at ESC Congress: Eliquis (apixaban) Significantly Reduced the Risk of All-Cause Hospitalization Versus Placebo in Patients with Venous Thromboembolism (VTE) 73 Aug 25, 2014: New Pradaxa data to be presented at the ESC Congress 2014 74 Jun 30, 2014: U.S. FDA grants Breakthrough Therapy Designation to Pradaxa (dabigatran etexilate) specific investigational antidote 75 Jun 20, 2014: Boehringer Ingelheim Initiates RE-CIRCUIT Trial, Evaluating Pradaxa (dabigatran etexilate mesylate) in NVAF Patients Undergoing Ablation 76 Jun 11, 2014: Portola Pharmaceuticals Announces Positive Phase 2 Data With FDA-Designated Breakthrough Therapy Andexanet Alfa and Enoxaparin 77 May 28, 2014: Xarelto from Bayer Submitted in Japan for the Treatment of Deep Vein Thrombosis and Pulmonary Embolism as well as for the Prevention of Recurrent Venous Thromboembolism 78 May 22, 2014: Antidote for rapid reversal of Pradaxa progresses into next stage of clinical investigation with study in patients 79 May 22, 2014: Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS-FXI Rx in the Prevention of Venous Thrombosis in Patients Undergoing Total Knee Replacement Surgery 79 May 15, 2014: As the benefits and safety of Pradaxa are once again confirmed, Boehringer Ingelheim continues to look for new ways for Pradaxa to help more patients 80 May 12, 2014: Portola Pharmaceuticals Begins Enrollment in Phase 3 Study of FDA-Designated Breakthrough Therapy Andexanet Alfa and Factor Xa Inhibitor XARELTO 82 Appendix 85 Methodology 85 Coverage 85 Secondary Research 85 Primary Research 85 Expert Panel Validation 85 Contact Us 86 Disclaimer 86
List of Tables Number of Products under Development for Venous Thromboembolism, H2 2014 8 Number of Products under Development for Venous Thromboembolism - Comparative Analysis, H2 2014 9 Number of Products under Development by Companies, H2 2014 11 Comparative Analysis by Late Stage Development, H2 2014 12 Comparative Analysis by Clinical Stage Development, H2 2014 13 Comparative Analysis by Early Stage Development, H2 2014 14 Products under Development by Companies, H2 2014 15 Venous Thromboembolism - Pipeline by Sanofi, H2 2014 16 Venous Thromboembolism - Pipeline by Isis Pharmaceuticals, Inc., H2 2014 17 Venous Thromboembolism - Pipeline by Daiichi Sankyo Company, Limited, H2 2014 18 Venous Thromboembolism - Pipeline by Bayer AG, H2 2014 19 Venous Thromboembolism - Pipeline by Portola Pharmaceuticals, Inc., H2 2014 20 Venous Thromboembolism - Pipeline by Green Cross Corporation, H2 2014 21 Venous Thromboembolism - Pipeline by Regado Biosciences, Inc., H2 2014 22 Venous Thromboembolism - Pipeline by GlycoMimetics, Inc., H2 2014 23 Venous Thromboembolism - Pipeline by Gamma Therapeutics, Inc., H2 2014 24 Assessment by Monotherapy Products, H2 2014 25 Number of Products by Stage and Target, H2 2014 27 Number of Products by Stage and Mechanism of Action, H2 2014 29 Number of Products by Stage and Route of Administration, H2 2014 31 Number of Products by Stage and Molecule Type, H2 2014 33 Venous Thromboembolism Therapeutics - Recent Pipeline Updates, H2 2014 54 Venous Thromboembolism - Dormant Projects, H2 2014 71 Venous Thromboembolism - Discontinued Products, H2 2014 72
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