Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Pipeline Review, H1 2016

Published: May, 2016 | Pages: 70 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Pipeline Review, H1 2016

Summary

Global Markets Direct's, 'Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Pipeline Review, H1 2016', provides in depth analysis on Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted pipeline therapeutics. 

The report provides comprehensive information on the Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted therapeutics development and features dormant and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.)
- The report reviews Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources 
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages 
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities 
- The report reviews key players involved in Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted therapeutics and enlists all their major and minor projects 
- The report assesses Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type 
- The report summarizes all the dormant and discontinued pipeline projects 
- The report reviews latest news and deals related to Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) targeted therapeutics

Reasons To Buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage 
- Identify and understand the targeted therapy areas and indications for Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies 
- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) development landscape 
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and Scope

 Table of Contents

Table of Contents 2
List of Tables 5
List of Figures 5
Introduction 6
Global Markets Direct Report Coverage 6
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) Overview 7
Therapeutics Development 8
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Products under Development by Stage of Development 8
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Products under Development by Therapy Area 9
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Products under Development by Indication 10
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Pipeline Products Glance 11
Late Stage Products 11
Early Stage Products 12
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Products under Development by Companies 13
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Therapeutics Assessment 16
Assessment by Monotherapy/Combination Products 16
Assessment by Mechanism of Action 17
Assessment by Route of Administration 18
Assessment by Molecule Type 20
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Companies Involved in Therapeutics Development 21
Akebia Therapeutics, Inc. 21
Bayer AG 22
Daiichi Sankyo Company, Limited 23
FibroGen, Inc. 24
GlaxoSmithKline Plc 25
Japan Tobacco Inc. 26
Merck & Co., Inc. 27
Sigmoid Pharma Limited 28
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Drug Profiles 29
AKB-6899 - Drug Profile 29
Product Description 29
Mechanism Of Action 29
R&D Progress 29
daprodustat - Drug Profile 30
Product Description 30
Mechanism Of Action 30
R&D Progress 30
dimethyloxalylglycine - Drug Profile 32
Product Description 32
Mechanism Of Action 32
R&D Progress 32
DS-1093 - Drug Profile 33
Product Description 33
Mechanism Of Action 33
R&D Progress 33
FG-2216 - Drug Profile 34
Product Description 34
Mechanism Of Action 34
R&D Progress 34
FG-4497 - Drug Profile 35
Product Description 35
Mechanism Of Action 35
R&D Progress 35
FG-6874 - Drug Profile 36
Product Description 36
Mechanism Of Action 36
R&D Progress 36
FG-8205 - Drug Profile 37
Product Description 37
Mechanism Of Action 37
R&D Progress 37
JTZ-951 - Drug Profile 38
Product Description 38
Mechanism Of Action 38
R&D Progress 38
molidustat - Drug Profile 39
Product Description 39
Mechanism Of Action 39
R&D Progress 39
roxadustat - Drug Profile 41
Product Description 41
Mechanism Of Action 41
R&D Progress 41
Small Molecules to Inhibit Prolyl Hydroxylase for Anemia - Drug Profile 47
Product Description 47
Mechanism Of Action 47
R&D Progress 47
vadadustat - Drug Profile 48
Product Description 48
Mechanism Of Action 48
R&D Progress 48
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Dormant Projects 54
Transmembrane Prolyl 4-Hydroxylase (Hypoxia-Inducible Factor Prolyl Hydroxylase 4 or EC 1.14.11.) - Featured News & Press Releases 55
May 05, 2016: Akebia Provides Update On Phase 3 INNO2VATE Program For Vadadustat 55
Apr 26, 2016: Akebia Therapeutics Announces Presentation of Vadadustat Phase 2 Dialysis Data at Upcoming National Kidney Foundation 2016 Spring Clinical Meetings 56
Apr 20, 2016: Promising Phase 2 Data Show Roxadustat Corrected Anemia In Chronic Kidney Disease Patients Before Intervention With Dialysis 56
Mar 09, 2016: Akebia Prevails in European Patent Dispute and Preserves Access to Key Market for Vadadustat 57
Feb 16, 2016: FibroGen Publishes Encouraging Phase 2 Anemia Data Demonstrating Roxadustat's Ability to Maintain Hemoglobin Levels in Patients With Chronic Kidney Disease 58
Jan 04, 2016: Akebia Initiates Phase 3 PRO2TECT Program 59
Nov 07, 2015: Akebia Announces Presentation of Vadadustat Phase 2 Dialysis Data at American Society of Nephrology Kidney Week 2015 Annual Meeting 60
Nov 03, 2015: FibroGen to Present Roxadustat Clinical Data in Four Presentations at American Society of Nephrology - Kidney Week 2015 61
Oct 28, 2015: Akebia Announces Presentations at the Upcoming American Society of Nephrology Kidney Week 2015 Annual Meeting 61
Oct 22, 2015: Phase 2 Data For Investigational Orally Active Hif-Phi Roxadustat Show Anemia Correction In Incident Dialysis Chronic Kidney Disease Patients Regardless Of Iron Repletion Status, Iron Supplementation Regimen, Or Dialysis Modality 63
Oct 06, 2015: Akebia Reaches Agreement with FDA and EMA on Vadadustat Global Phase 3 Program 64
Sep 08, 2015: Akebia Announces Positive Top-Line Results from its Phase 2 Study of Vadadustat in Dialysis Patients with Anemia Related to Chronic Kidney Disease 65
Aug 12, 2015: Nephrology Dialysis Transplantation Reports Phase 2 Data Of Investigational Orally Active Hif-Phi Roxadustat (Fg-4592) Shows Improved Hemoglobin Levels In Non-Dialysis Ckd Subjects With Anemia 66
May 29, 2015: Akebia Announces Presentation of Phase 2b Data for AKB-6548 in Non-Dialysis Patients with Anemia Related to Chronic Kidney Disease at the 52nd ERA-EDTA Congress 67
May 26, 2015: Akebia Therapeutics Announces Presentation of AKB-6548 Phase 2b Data at the 52nd ERA-EDTA Annual Congress 67
Appendix 69
Methodology 69
Coverage 69
Secondary Research 69
Primary Research 69
Expert Panel Validation 69
Contact Us 69
Disclaimer 70

List of Tables

Number of Products under Development for, H1 2016 8
Number of Products under Development by Therapy Area, H1 2016 9
Number of Products under Development by Indication, H1 2016 10
Comparative Analysis by Late Stage Development, H1 2016 11
Comparative Analysis by Early Stage Products, H1 2016 12
Number of Products under Development by Companies, H1 2016 13
Products under Development by Companies, H1 2016 14
Products under Development by Companies, H1 2016 (Contd..1) 15
Assessment by Monotherapy/Combination Products, H1 2016 16
Number of Products by Stage and Mechanism of Action, H1 2016 17
Number of Products by Stage and Route of Administration, H1 2016 19
Number of Products by Stage and Molecule Type, H1 2016 20
Pipeline by Akebia Therapeutics, Inc., H1 2016 21
Pipeline by Bayer AG, H1 2016 22
Pipeline by Daiichi Sankyo Company, Limited, H1 2016 23
Pipeline by FibroGen, Inc., H1 2016 24
Pipeline by GlaxoSmithKline Plc, H1 2016 25
Pipeline by Japan Tobacco Inc., H1 2016 26
Pipeline by Merck & Co., Inc., H1 2016 27
Pipeline by Sigmoid Pharma Limited, H1 2016 28
Dormant Projects, H1 2016 54