Tissue Sealants

Published: Apr, 2015 | Pages: 404 | Publisher: RESEARCH IMPACT TECHNOLOGIES
Industry: Biotechnology | Report Format: Electronic (PDF)

This market insight report on Tissue Sealants provides an in depth analysis of the global Tissue Sealants market including various sources of Sealants and the various applications. The Sources of Tissue Sealants covered include Homologous Sealants, Synthetic Sealants and Autologous Sealants. The applications of Tissue Sealants covered include Odontology, Cardiology, Neurology, Orthopedics and Other (such as Urology, Hepatic, and Dermatology etc.). The study includes estimations and predictions for the total global Tissue Sealants market and also key regional markets including North America, Europe, Asia-Pacific, Latin America and Rest of World. Estimations and predictions (120 exhibits) are illustrated graphically for the analysis period 2005-2020. More than 100 companies are covered while business profiles of 24 major companies are discussed in the report. The report serves as a guide to global Tissue Sealants market. Information related to recent product releases, product developments, partnerships, collaborations, and mergers and acquisitions also covered in the report. Compilation of Worldwide Patents and Research related to Tissue Sealants is also provided.

 Table of Content

I. SCOPE AND METHODOLOGY	1
II. REPORT SYNOPSIS	4
Introduction	4
Medical Need and Market Opportunity	5
Current Treatment	5
Hemostasis	6
Hemostat	6
Hemostatic Agent	6
Tissue Sealant	7
Sealant	7
Fibrin	7
Thrombin	8
Segmentation of Tissue Sealants Market	8
Exhibit 1. Segmentation of Tissue Sealants Market by Source and Therapeutic Application	8
Sources of Tissues Sealants	8
Homologous/Pooled Tissue Sealants	8
Synthetic/ Commercial Tissue Sealants	8
Autologous Fibrin Sealants	9
Therapeutic Applications	9
Exhibit 2. List of Some Popular Tissue Sealants	9
Tissue Sealants - Global Market Analysis	10
Exhibit 3. Tissue Sealants – Global Market Estimations & Predictions (2005 -2020) in US$ Million	10
Exhibit 4. List of Major Global Tissue Sealants Companies	11
III. MARKET DYNAMICS	12
Market Overview	12
Exhibit 5. M&A Activities in Tissue Sealants Market	12
Global Tissue Sealants Market	14
Exhibit 6. Tissue Sealants - Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	14
Exhibit 7. Tissue Sealants - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	15
North American Tissue Sealants Market	16
Exhibit 8. Tissue Sealants – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	16
Exhibit 9. Tissue Sealants - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	17
United States Tissue Sealants Market	17
Canadian Tissue Sealants Market	17
Exhibit 10. List of Major North American Tissue Sealants Companies	17
Asia-Pacific Tissue Sealants Market	18
Exhibit 11. Tissue Sealants –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	18
Exhibit 12. Tissue Sealants - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	19
Japanese Tissue Sealants Market	19
Australian Tissue Sealants Market	19
Chinese Tissue Sealants Market	19
Indian Tissue Sealants Market	20
South Korean Tissue Sealants Market	20
Exhibit 13. List of Major Asia-Pacific Tissue Sealants Companies	20
European Tissue Sealants Market	21
Exhibit 14. Tissue Sealants – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, the Netherlands, Russia and Rest of Europe in US$ Million	21
Exhibit 15. Tissue Sealants - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, the Netherlands, Russia and Rest of Europe	22
German Tissue Sealants Market	22
UK Tissue Sealants Market	22
French Tissue Sealants Market	22
Dutch Tissue Sealants Market	23
Russian Tissue Sealants Market	23
Exhibit 16. List of Major European Tissue Sealants Companies	23
Latin American Tissue Sealants Market	24
Exhibit 17. Tissue Sealants – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	24
Exhibit 18. Tissue Sealants – Latin American Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	25
Brazilian Tissue Sealants Market	25
Rest of World Tissue Sealants Market	26
Exhibit 19. Tissue Sealants – Rest of World Market Estimations & Predictions (2005 -2020) by Country for  South Africa, Israel and Other Countries in US$ Million	26
Exhibit 20. Tissue Sealants – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel and Other Countries	27
South African Tissue Sealants Market	27
Israeli Tissue Sealants Market	27
Exhibit 21. Cost of Few Available Tissue Sealants	27
Major Global Companies In Tissue Sealants Market	28
3M Company (USA)	28
Abbott Laboratories (USA)	29
Advanced Medical Solutions Group plc (UK)	31
B. Braun Melsungen AG (Germany)	32
Baxter International, Inc. (USA)	33
C. R. Bard, Inc. (USA)	34
Cohera Medical, Inc. (USA)	35
Covidien PLC (Ireland)	37
CryoLife, Inc. (USA)	38
CSIRO (Australia)	38
CSL Behring (USA)	39
Ethicon, Inc. (USA)	39
GluStitch, Inc. (USA)	41
Guangzhou Bioseal Biotechnology Co., Ltd. (China)	42
KAKETSUKEN (Japan)	42
Koninklijke DSM N.V (The Netherlands)	43
LABORATOIRES URGO (France)	43
Olympus Terumo Biomaterials Corporation (Japan)	44
Pfizer, Inc. (USA)	44
ProFibrix NV (The Netherlands)	45
Shanghai Pine & Power Biotech Co., Ltd. (China)	45
Takeda Pharmaceuticals International GmbH (Switzerland)	46
ThermoGenesis Corporation (USA)	46
Tissuemed Ltd. (UK)	47
Vivostat A/S (Denmark)	48
Major Activities in Tissue Sealants Market	49
Zimmer Holdings to Merge with Biomet	49
Cardinal Health Acquires AccessClosure	49
AccessClosure Introduces Next-Generation Mynx™ Ace Vascular Closure Device	49
Integra LifeSciences Introduces Integra® Wound Matrix (Thin) to Expand Skin and Wound Product Line	49
Cesca Therapeutics Merges with TotipotentRX Corporation to Form Rancho Cordova	50
Vascular Solutions Introduces ThrombiDisc™ Topical Hemostat in the US	50
LifeCell Corporation Takes Over Advanced Adipose Tissue Injector	50
Integra LifeSciences Acquires DuraSeal Product Range from Covidien	51
Harvest Technologies Launches AdiPrep ® Adipose Concentration	51
Avalon Medical Introduces Veterinary Surgical Tissue Patching Product	51
Merz Pharma Group Takes Over Swiss Aesthetics Company Anteis	52
Tenaxis Medical Obtains CE Mark Approval to Expand Indications for Its ArterX® Surgical Sealant	52
Bard Acquires Medafor, Inc.	52
The Medicines Company Acquires ProFibrix Following the Successful Completion of Phase III Trial for Fibrocaps	53
ThermoGenesis Merges with Stem Cell Company	53
Angiotech Pharmaceuticals Sells Interventional Products Business to Argon Medical Devices	54
Cohera Presents Innovative Surgical Adhesive for Effective Healing after Mastectomy Procedures	54
Z-Medica Introduces New Range of Hemostatic Agents for EMS Requirements	54
Z-Medica Extends CE Indications for Quikclot Hemostatic Dressings for Widening Its Application in Surgical Wound Care	55
Abbott Forms Research-Based Pharmaceuticals Business	55
EVARREST™ Fibrin Sealant Patch gains FDA Approval	55
Smith & Nephew Inks an Agreement to Buy Healthpoint and Reinforce the Company’s Wound Care Business	56
Bard Buys Neomend	56
DSM Buys Kensey Nash to Reinforce the Biomedical Business	56
ThermoGenesis Announces Divestiture of CryoSeal® Product Line	56
Johnson & Johnson Acquires Bioseal	57
Cohera Receives Platform Patent for Proprietary Biodegradable Adhesive Technology	57
AccessClosure Unveils MynxGrip™ Vascular Closure Device	57
Baxter Receives FDA Approval for Expanded Indication for TISSEEL [Fibrin Sealant] for General Hemostasis in Surgery	58
Phase II Clinical Trials of ProFibrix with Fibrocaps™ Concludes – Gearing Up for Phase III	58
Cohera Medical Markets TissuGlu® Surgical Adhesive in Germany	58
Covidien Introduces for the First time, Non-Absorbable, Uni-Directional Knotless Suture	59
Advanced Medical Solutions Enters into a Pre-Supply and Development Agreement with Surgical Innovations	59
Takeda Acquires Nycomed	59
Aesculap Completes Acquisition of Aragon Surgical, Inc.	59
Pathfinder Merges with SyntheMed	60
Cohera Medical Attains CE Mark approval for TissuGlu® Surgical Adhesive	60
Baxter Gains FDA Approval for ARTISS Fibrin Sealant for application in Facial Rhytidectomy Procedures	60
US Patent for Spinal Restoration’s Biostat® System	60
ThermoGenesis Receives 510(k) Approval for the Usage of RES-Q in Platelet Rich Plasma Preparation	61
Sanofi-Aventis Completes Acquisition of Genzyme Corporation	61
Pfizer Completes Acquisition of King Pharma	61
AccessClosure Launches New Mynx Cadence™ Vascular Closure Device	61
Kensey Nash Acquires Nerites Corporation’s Assets	62
Kuros and Ethicon in Licensing Agreement	62
CryoLife Obtains Japanese Regulatory Approval for BioGlue Surgical Adhesive	62
Smith & Nephew Launches NO-STING SKIN-PREP for Skin Protection	63
CryoLife Enters into Agreement with Starch Medical Inc.	63
DSM and Dupont Announce JV in Surgical Biomedical Materials	63
Tissuemed Obtains Notified Body Approval for TissuePatchThoracic as Addition to its TissuePatch™ Product Family	64
Ethicon Introduces OMNEX™ Surgical Sealant	64
Asahi Kasei Kuraray Medical and ThermoGenesis Corp., Amends Distribution and License Agreement	64
CryoLife Buys Patent Pertaining to BioGlue(R) Surgical Adhesive	64
HyperBranch Announces Receipt of CE Mark for its Adherus™ Spinal Sealant Product Line	65
ProFibrix and CSL Behring Enter into Fibrinogen and Thrombin Supply Agreement	65
Kensey Nash Enters into Strategic Agreement with Arthrex for Extracellular Matrix Products	65
3M Launches Novel 3M™ Tegaderm™	66
Angiotech Acquires Haemacure Corp.	66
Nuseal Brand’s Changes Name to Adherus	66
American Podiatric Medical Association Awards Seal of Approval to PriMatrix™ of TEI Biosciences	66
Tissuemed Obtains Patents	67
Vascular Solutions and Zerusa Receive Marketing Clearance from FDA for the Next Generation Guardian II Hemostasis Valve	67
I-Therapeutix Inc., Changes Name to Ocular Therapeutix Inc	67
HyperBranch Medical Technology Inc., Receives CE Mark for NuSeal 100 Dural Sealant	67
Adhezion Biomedical Receives FDA Marketing Approval for FLORASEAL™ Microbial Sealant	68
TEI Biosciences Enters Marketing and Distribution Agreement; Receives First Order for SurgiMend® in Israel	68
Access Closure Introduces First True 5 French Vascular Closure Device	68
Vascular Solutions Launches Muskie™ Guidewires	68
Kuros Consolidates Lead Position in Fibrin-based Biomaterial-Biologic Combination Products	69
TEI Biosciences Launches SurgiMend® 2.0, 3.0, and 4.0 following Clearance from FDA	69
Medline Industries Introduces MatriStem™ Extracellular Matrix Wound Sheet	69
HyperBranch Medical Technology Licenses OcuSeal™ Liquid Ocular Bandage to BD	70
Adhezion Biomedical Receives FDA Marketing Approval for FLORASEAL™ SURGISEAL™ Topical Skin Adhesive	70
Johnson & Johnson Acquires Omrix Biopharmaceuticals	70
Kuros Obtains US Patent for Synthetic Biomaterials	70
Kuros and Aeris Enter Exclusive Licensing Agreement in the Field of Lung Volume Reduction	71
Cohera Medical Receives Phase II SBIR Grant for TissuGlu®	71
BioGlue® Surgical Adhesive Obtains European Approval Browlift Cosmetic and Reconstructive Plastic Surgery Use	71
Vivolution A/S is Now Vivostat A/S	72
Haemacure Reveals Promising Outcome from Preclinical Research of Proprietary Fibrin Sealant used for Preventing Tissue Adhesion	72
FDA Approves a New Medical Adhesive Effective in Skin Grafts on Burn Patients	73
Hemostatic Product Candidate Fibrin Patch of OMRIX Biopharmaceuticals Approved for Further Clinical Trial by the FDA	73
Expanded FDA Approval for EVICEL™ Liquid Fibrin Sealant (Human) of OMRIX	73
FDA Approves Revised Labeling of THROMBIN-JMI® of King Pharmaceutical	74
Vivolution Procures an Exclusive License Range from Bristol-Myers Squibb	74
Baxter Markets TachoSil® Patch in the US	74
GELFOAM® plus Hemostasis kit of Baxter Approved	75
Genzyme Corporation Licenses Hernia Product and Technology to Bard	75
State-of-the-Art Manufacturing Facility Construction Commenced by Haemacure	75
TEI Biosciences Inc. Introduced SurgiMend™ Collagen Matrix for Soft Tissue Refabrication	76
Proxy Biomedical and CryoLife in Agreement to Provide BioGlue® Surgical Adhesive in Hernia Repair Kit of Surgical Mesh by Proxy	76
King Pharmaceuticals and Vascular Solutions in Licensing Agreements	76
FDA Approves EVITHROM Thrombin Topical (Human), A Thrombin Stand Alone Product of OMRIX, for the Indication of General Hemostasis in Surgery	77
MAA for Evicel™ in the Indication of General Hemostasis filed by OMRIX	77
Protein Polymer Technologies in Surgical Sealant Product Agreement	77
Restriction on Arista™AH Absorbable Urological Surgical Hemostat of Medafor Withdrawn by the FDA	77
Tyco Healthcare to be known as Covidien	78
FDA Approves THROMBIN-JMI® Epistaxis Kit of King Pharmaceuticals	78
Nycomed Shifts Headquarters to Zurich, Switzerland	78
Baxter in Licensing Agreements with Spinal Restoration and Intercytex	78
BioFoam® of CryoLife Granted US Patent	79
Encelle Acquired by Pioneer Surgical	79
Evicel™ Liquid Fibrin Sealant of OMRIX Approved by FDA for Vascular Surgery Application	80
King Pharmaceuticals Acquires Hemostatic Products License from Gelita Medical	80
Self-Retaining System Quill® Launched by Angiotech	81
Synovis Life Technologies Receives U.S. FDA’s Clearance for Additional Indication Related to Veritas(R) Collagen Matrix	81
Upcoming Collaborative Campaign by Consolidation of Biomaterials Business of Olympus and Collagen Business of Terumo	82
IND Filed by OMRIX for Adhexil in Anti-Adhesion Application	82
Rigid Applicator Tip for BioGlue® Surgical Adhesive Approved in Canada and Europe	82
Nycomed Acquires ALTANA Pharma	83
Medafor Launches FlexiTip™ Applicator to Deliver Arista™AH Absorbable Surgical Hemostat at Difficult to Access Sites	83
BioForm Medical and CryoLife in Development and Marketing Agreement for BioGlue® in Cosmetic and Plastic Surgery Applications	83
Synovis Life Technologies Executes a Marketing Agreement with Caldera Medical	83
MPatch® Vascular Closure Device Launched Internationally by Medafor	84
ADEPT® (4% Icodextrin Solution) for Adhesion Reduction Approved by the FDA	84
Confluent Surgical Acquired by Tyco International	85
Romanian Pharmaceutical Company Ruby De Tacos Acquired by Nycomed	85
Possis Medical Launches Endovascular Access Site Management Solution	85
Surgical Specialties Corporation and Collagen Matrix Technologies in Agreement for Dermalogen™ injectable dermal filler products	85
DuraSeal® Sealant granted CE Mark for Vascular Applications	86
New Spreader Tips for BioGlue® Syringe Applicator Approved by the FDA	86
900 Hospitals Agree to Order Supplies from U.S. Surgical Under the new Novation Supply Agreements	86
Baxter and Kuros Disclose Partnership and License Agreement	87
DuraSeal Xact™ System Acquires CE Mark for Spine Applications Discloses Confluent Surgical	87
DuraSeal Xact™ System Acquires CE Mark for Thoracic Applications	88
Pharming’s Recombinant Human Fibrinogen to be Used in US Army Project	88
Pharming and NovaThera Collaborate for Developing New Biomedical Products	89
Johnson & Johnson Acquires CLOSURE Medical Corporation	89
Kensey Nash in Agreement with St. Jude Medical for Angio-Seal™ Component Supply	90
First Cranial Dural Sealant Approved by the FDA	90
Analysis by Source	91
Exhibit 22. Tissue Sealants by Source – Global Market Estimations & Predictions (2005 -2020) by Source for Homologous Sealants, Synthetic Sealants and Autologous Sealants in US$ Million	91
Exhibit 23. Tissue Sealants by Source - Global Market Shares (2010, 2015 & 2020) for Homologous Sealants, Synthetic Sealants and Autologous Sealants	92
Homologous Sealants	93
Global Homologous Sealants Market	93
Exhibit 24. Homologous Sealants – Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	93
Exhibit 25. Homologous Sealants - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	94
North American Homologous Sealants Market	95
Exhibit 26. Homologous Sealants – North American Market Estimations & Predictions (2005 -2020) by country for United States and Canada in US$ Million	95
Exhibit 27. Homologous Sealants - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	96
United States Homologous Sealants Market	96
Canadian Homologous Sealants Market	96
Asia-Pacific Homologous Sealants Market	97
Exhibit 28. Homologous Sealants –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	97
Exhibit 29. Homologous Sealants - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	98
Japanese Homologous Sealants Market	98
Australian Homologous Sealants Market	98
Chinese Homologous Sealants Market	98
Indian Homologous Sealants Market	98
South Korean Homologous Sealants Market	98
European Homologous Sealants Market	99
Exhibit 30. Homologous Sealants – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, the Netherlands, Russia and Rest of Europe in US$ Million	99
Exhibit 31. Homologous Sealants - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	100
German Homologous Sealants Market	100
UK Homologous Sealants Market	100
French Homologous Sealants Market	100
Dutch Homologous Sealants Market	100
Russian Homologous Sealants Market	100
Latin American Homologous Sealants Market	101
Exhibit 32. Homologous Sealants – Latin American Market Estimations & Predictions (2005 -2020) By Country for Brazil and Rest of Latin America in US$ Million	101
Exhibit 33. Homologous Sealants - Latin American Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	102
Brazilian Homologous Sealants Market	102
Rest of World Homologous Sealants Market	103
Exhibit 34. Homologous Sealants – Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel and Other Countries in US$ Million	103
Exhibit 35. Homologous Sealants - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	104
South African Homologous Sealants Market	104
Israeli Homologous Sealants Market	104
Synthetic Sealants	105
Global Synthetic Sealants Market	105
Exhibit 36. Synthetic Sealants – Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	105
Exhibit 37. Synthetic Sealants - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	106
North American Synthetic Sealants Market	107
Exhibit 38. Synthetic Sealants – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	107
Exhibit 39. Synthetic Sealants - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	108
United States Synthetic Sealants Market	108
Canadian Synthetic Sealants Market	108
Asia-Pacific Synthetic Sealants Market	109
Exhibit 40. Synthetic Sealants –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	109
Exhibit 41. Synthetic Sealants - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	110
Japanese Synthetic Sealants Market	110
Australian Synthetic Sealants Market	110
Chinese Synthetic Sealants Market	110
Indian Synthetic Sealants Market	110
South Korean Synthetic Sealants Market	110
European Synthetic Sealants Market	111
Exhibit 42. Synthetic Sealants – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	111
Exhibit 43. Synthetic Sealants - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	112
German Synthetic Sealants Market	112
UK Synthetic Sealants Market	112
French Synthetic Sealants Market	112
Dutch Synthetic Sealants Market	112
Russian Synthetic Sealants Market	112
Latin American Synthetic Sealants Market	113
Exhibit 44. Synthetic Sealants – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	113
Exhibit 45. Synthetic Sealants - Latin American Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	114
Brazilian Synthetic Sealants Market	114
Rest of World Synthetic Sealants Market	115
Exhibit 46. Synthetic Sealants – Rest of World Market Estimations & Predictions (2005 -2020) by Country for Israel, South Africa and Other Countries in US$ Million	115
Exhibit 47. Synthetic Sealants - Rest of World Market Shares (2010, 2015 & 2020) by Country for Israel, South Africa and Other Countries	116
South African Synthetic Sealants Market	116
Israel Synthetic Sealants Market	116
Autologous Sealants	117
Global Autologous Sealants Market	117
Exhibit 48. Autologous Sealants – Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	117
Exhibit 49. Autologous Tissue Sealants - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	118
North American Autologous Sealants Market	119
Exhibit 50. Autologous Sealants – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	119
Exhibit 51. Autologous Sealants - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	120
United States Autologous Sealants Market	120
Canadian Autologous Sealants Market	120
Asia-Pacific Autologous Sealants Market	121
Exhibit 52. Autologous Sealants –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	121
Exhibit 53. Autologous Sealants - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	122
Japanese Autologous Sealants Market	122
Australian Autologous Sealants Market	122
Chinese Autologous Sealants Market	122
India Autologous Sealants Market	122
South Korean Autologous Sealants Market	122
European Autologous Sealants Market	123
Exhibit 54. Autologous Sealants – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	123
Exhibit 55. Autologous Sealants - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	124
German Autologous Sealants Market	124
UK Autologous Sealants Market	124
French Autologous Sealants Market	124
Dutch Autologous Sealants Market	124
Russian Autologous Sealants Market	124
Latin American Autologous Sealants Market	125
Exhibit 56. Autologous Sealants – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	125
Exhibit 57. Autologous Sealants – Latin American Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	126
Brazilian Autologous Sealants Market	126
Rest of World Autologous Sealants Market	127
Exhibit 58. Autologous Sealants – Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel, and Other Countries in US$ Million	127
Exhibit 59. Autologous Sealants – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	128
South African Autologous Sealants Market	128
Israeli Autologous Sealants Market	128
Analysis by Application	129
Exhibit 60. Tissue Sealants by Therapeutic Application – Global Market Estimations & Predictions (2005 -2020) for Odontology, Cardiology, Neurology, Orthopedics and Other in US$ Million	129
Exhibit 61. Tissue Sealants by Therapeutic Application - Global Market Shares (2010, 2015 & 2020) for Odontology, Cardiology, Neurology, Orthopedics and Other	130
Odontology	131
Global Market for Tissue Sealants in Odontology	131
Exhibit 62. Tissue Sealants in Odontology – Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	131
Exhibit 63. Tissue Sealants in Odontology - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	132
North America Market for Tissue Sealants in Odontology	133
Exhibit 64. Tissue Sealants in Odontology – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	133
Exhibit 65. Tissue Sealants in Odontology - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	134
Asia-Pacific Market for Tissue Sealants in Odontology	135
Exhibit 66. Tissue Sealants in Odontology –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	135
Exhibit 67. Tissue Sealants in Odontology - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	136
European Market for Tissue Sealants in Odontology	137
Exhibit 68. Tissue Sealants in Odontology – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	137
Exhibit 69. Tissue Sealants in Odontology - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	138
Latin America Market for Tissue Sealants in Odontology	139
Exhibit 70. Tissue Sealants in Odontology – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	139
Exhibit 71. Tissue Sealants in Odontology – Latin America Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	140
Rest of World Market for Tissue Sealants in Odontology	141
Exhibit 72. Tissue Sealants in Odontology – Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel, and Other Countries in US$ Million	141
Exhibit 73. Tissue Sealants in Odontology – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	142
Cardiology	143
Global Market for Tissue Sealants in Cardiology	143
Exhibit 74. Tissue Sealants in Cardiology – Global Market Estimations & Predictions (2005 -2020) by Country for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	143
Exhibit 75. Tissue Sealants in Cardiology - Global Market Shares (2010, 2015 & 2020) by Country for North America, Asia-Pacific, Europe, Latin America and Rest of World	144
North America Market for Tissue Sealants in Cardiology	145
Exhibit 76. Tissue Sealants in Cardiology – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	145
Exhibit 77. Tissue Sealants in Cardiology - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	146
Asia-Pacific Market for Tissue Sealants in Cardiology	147
Exhibit 78. Tissue Sealants in Cardiology –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	147
Exhibit 79. Tissue Sealants in Cardiology - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	148
European Market for Tissue Sealants in Cardiology	149
Exhibit 80. Tissue Sealants in Cardiology – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, the Netherlands, Russia and Rest of Europe in US$ Million	149
Exhibit 81. Tissue Sealants in Cardiology - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	150
Latin America Market for Tissue Sealants in Cardiology	151
Exhibit 82. Tissue Sealants in Cardiology – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	151
Exhibit 83. Tissue Sealants in Cardiology – Latin American Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	152
Rest of World Market for Tissue Sealants in Cardiology	153
Exhibit 84. Tissue Sealants in Cardiology – Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel, and Other Countries in US$ Million	153
Exhibit 85. Tissue Sealants in Cardiology – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	154
Neurology	155
Global Market for Tissue Sealants in Neurology	155
Exhibit 86. Tissue Sealants in Neurology – Global Market Estimations & Predictions (2005 -2020) by Geo-graphic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	155
Exhibit 87. Tissue Sealants in Neurology - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	156
North America Market for Tissue Sealants in Neurology	157
Exhibit 88. Tissue Sealants in Neurology – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	157
Exhibit 89. Tissue Sealants in Neurology - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	158
Asia-Pacific Market for Tissue Sealants in Neurology	159
Exhibit 90. Tissue Sealants in Neurology –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	159
Exhibit 91. Tissue Sealants in Neurology - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	160
European Market for Tissue Sealants in Neurology	161
Exhibit 92. Tissue Sealants in Neurology – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	161
Exhibit 93. Tissue Sealants in Neurology - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	162
Latin America Market for Tissue Sealants in Neurology	163
Exhibit 94. Tissue Sealants in Neurology – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	163
Exhibit 95. Tissue Sealants in Neurology – Latin America Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	164
Rest of World Market for Tissue Sealants in Neurology	165
Exhibit 96. Tissue Sealants in Neurology – Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel, and Other Countries in US$ Million	165
Exhibit 97. Tissue Sealants in Neurology – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	166
Orthopedics Market	167
Global Market for Tissue Sealants in Orthopedics	167
Exhibit 98. Tissue Sealants in Orthopedics – Global Market Estimations & Predictions (2005 -2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	167
Exhibit 99. Tissue Sealants in Orthopedics - Global Market Shares (2010, 2015 & 2020) by Geographic Regions for North America, Asia-Pacific, Europe, Latin America and Rest of World	168
North American Market for Tissue Sealants in Orthopedics	169
Exhibit 100. Tissue Sealants in Orthopedics – North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	169
Exhibit 101. Tissue Sealants in Orthopedics - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	170
Asia-Pacific Market for Tissue Sealants in Orthopedics	171
Exhibit 102. Tissue Sealants in Orthopedics –Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	171
Exhibit 103. Tissue Sealants in Orthopedics - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	172
European Market for Tissue Sealants in Orthopedics	173
Exhibit 104. Tissue Sealants in Orthopedics – European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	173
Exhibit 105. Tissue Sealants in Orthopedics - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	174
Latin American Market for Tissue Sealants in Orthopedics	175
Exhibit 106. Tissue Sealants in Orthopedics – Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	175
Exhibit 107. Tissue Sealants in Orthopedics – Latin America Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	176
Rest of World Market for Tissue Sealants in Orthopedics	177
Exhibit 108. Tissue Sealants in Orthopedics – Rest of World Market Estimations & Predictions (2005 -2020) for South Africa, Israel, and Other Countries in US$ Million	177
Exhibit 109. Tissue Sealants in Orthopedics – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel and Other Countries	178
Other Therapeutic Areas	179
Global Market for Tissue Sealants in Other Therapeutic Areas	179
Exhibit 110. Tissue Sealants in Other Therapeutic Area - Global Market Estimations & Predictions (2005 -2020) by Country for North America, Asia-Pacific, Europe, Latin America and Rest of World in US$ Million	179
Exhibit 111. Tissue Sealants in Other Therapeutic Area - Global Market Shares (2010, 2015 & 2020) by Country for North America, Asia-Pacific, Europe, Latin America and Rest of World	180
North American Market for Tissue Sealants in Other Therapeutic Areas	181
Exhibit 112. Tissue Sealants in Other Therapeutic Area -North American Market Estimations & Predictions (2005 -2020) by Country for United States and Canada in US$ Million	181
Exhibit 113. Tissue Sealants in Other Therapeutic Area - North American Market Shares (2010, 2015 & 2020) by Country for United States and Canada	182
Asia-Pacific Market for Tissue Sealants in Other Therapeutic Areas	183
Exhibit 114. Tissue Sealants in Other Therapeutic Area – Asia-Pacific Market Estimations & Predictions (2005 -2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific in US$ Million	183
Exhibit 115. Tissue Sealants in Other Therapeutic Area - Asia-Pacific Market Shares (2010, 2015 & 2020) by Country for Japan, Australia, China, India, South Korea and Rest of Asia-Pacific	184
European Market for Tissue Sealants in Other Therapeutic Areas	185
Exhibit 116. Tissue Sealants in Other Therapeutic Area -European Market Estimations & Predictions (2005 -2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe in US$ Million	185
Exhibit 117. Tissue Sealants in Other Therapeutic Area - European Market Shares (2010, 2015 & 2020) by Country for Germany, UK, France, The Netherlands, Russia and Rest of Europe	186
Latin American Market for Tissue Sealants in Other Therapeutic Areas	187
Exhibit 118. Tissue Sealants in Other Therapeutic Area -Latin American Market Estimations & Predictions (2005 -2020) by Country for Brazil and Rest of Latin America in US$ Million	187
Exhibit 119. Tissue Sealants in Other Therapeutic Area – Latin America Market Shares (2010, 2015 & 2020) by Country for Brazil and Rest of Latin America	188
Rest of World Market for Tissue Sealants in Other Therapeutic Areas	189
Exhibit 120. Tissue Sealants in Other Therapeutic Area -Rest of World Market Estimations & Predictions (2005 -2020) by Country for South Africa, Israel, and Other Countries in US$ Million	189
Exhibit 121. Tissue Sealants in Other Therapeutic Area – Rest of World Market Shares (2010, 2015 & 2020) by Country for South Africa, Israel, and Other Countries	190
Tissue Sealants – Market Outlook	191
IV. PRODUCT/TECHNOLOGY RESEARCH	194
Introduction	194
Hemostasis	195
Hemostat	196
Topical Hemostats	196
Classification of Topical Hemostats	196
Mechanical Hemostats	196
Active Hemostats	197
Flowable Hemostats	197
Fibrin Sealants	197
Drawbacks of Topical Hemostatic Agents	197
Commercially Available Hemostats	198
Superstat®	198
Superstat – A Non-Cross Linked Collagen	198
Acid Wash Technique to Form Non-Cross Linked Chains	199
Lyophilization or Freeze Drying Mechanism	199
Functions of Superstat	199
Coagulation Cascade	199
Unique Features of Superstat	199
Benefits of Superstat	200
Applications of Superstat	201
Method of Administration	201
Avitene- Microfibrillar Collagen Hemostat	201
Mechanism	201
INSTAT	202
Areas of Application	202
Guidelines for Application in Endoscopic Practices	202
Caution against use of INSTAT Hemostat	202
Usage Guidelines: INSTAT Hemostat	203
Precautions to be followed during Usage	203
Adverse Reactions on Usage of Other Collagens	204
Clinical Evaluations	204
Package	204
Storage	204
Marketing Limitations	204
Gelfoam®	205
Mechanism	205
Gelfoam in Animal Studies	206
Usage	206
Dosage and Administration	206
Warnings	207
Precautions	207
Adverse Reactions and Complications	209
Thrombin-JMI and Thrombinar	209
Tissue Sealants	209
Surgical Application	210
Sources of Tissue Sealants	212
Homologous/Pooled Tissue Sealants	212
Exhibit 122. List of Homologous Tissue Sealants	212
Gelatin Matrix/Thrombin Sealants (FloSeal)	213
Method of Use	213
Mode of Action	214
Benefits of FloSeal	214
Bovine Serum Albumin and Glutaraldehyde (Bio Glue)	214
Composition and Mode of Action	214
Administration and Time	215
Applications	215
Characteristics	215
Synthetic/ Commercial Tissue Sealants	215
Synthetic Glues or Cyanoacrylates	215
Exhibit 123. List of Cyanoacrylate based Tissue Sealants	216
Polyethylene Glycol Hydrogels (DuralSeal® and CoSeal)	217
Focalseal	217
Autologous Fibrin Sealants	219
Therapeutic Applications	220
Odontology	220
Dental Sealants	220
Sealants Application	220
Exhibit 124. List of Tissue Sealants for Odontology Applications	221
Cardiology	221
Exhibit 125. List of Tissue Sealants for Cardiology Applications	222
Neurology	223
Exhibit 126. List of Tissue Sealants for Neurological Applications	223
Orthopedics	224
Exhibit 127. List of Tissue Sealants for Orthopedic Applications	224
Bone Healing	224
Bone Replacement	224
Cartilage Repair	224
Other Applications	225
Exhibit 128. List of Tissue Sealants for Other Applications	225
Gastrointestinology	226
Pneumothoracic Surgery	227
Urology	227
Renal Sparing Surgery	228
Otology	228
Reconstructive Surgery	228
Tissue Sealants – Research Briefs	229
Synthetic Collagen Helps Natural Clotting	229
Bio-Inspired Glue Keeps Heart Properly Closed	229
Discovery of Biomaterials that Repair Heart	230
Slug Adhesive – Future with no Stitches	230
New Tissue Engineering helps Nerve Repair	231
Topical Analgesic May Give Pain-Free ‘Skin Glue’ Repair of Cuts in Kids	232
Superglue for Cells	233
Developing and Categorizing of Poloxamine based Hydrogels as Tissue Sealants	233
Transporous Hernia Mesh Fixation with Fibrin Sealant in an in vitro Model Demonstration of Seal use	233
Remora Fish and a Novel Bio-Adhesive	234
‘Glue’ Obtained from Mussel to be used for Surgical Repair And Delivery of Cancer Drugs	235
Latest Emphysema Process Tested	236
Avoiding Leaking by Sealing Colon Anastomosis Experiment in Mouse Model	237
A Novel Adhesive for Surgery Obtained From Mussels	237
Enhancement of the Capacity of Adhesive Hydrogels in Cases of Post Swelling Surgical Sealant	238
Use of Porcupine Quills	238
Tissue Patch, a New Artificial Sealant for Repairing Superficial Lung Defect In vitro Test Results	240
Fibrin Sealant Effectiveness for Tissue Adherence in Facial Rhytidectomy	240
High Thrombin Levels in Fibrin Sealants cause Apoptosis in Human Keratinocytes	240
Assessing Alginate Dialdehyde Cross-Linked Gelatin Hydrogel as a Biodegradable Sealant for Polyester Vascular Graft	241
Biocompatible Tissue Glues -Silk Fibroin and Polyethylene Glycol	241
Novel Sealant Gels is useful in Closing Spinal Wounds after Surgery	242
Tensile Strength of Biological Fibrin Sealants	242
A Solution to a Sticky Problem	243
Histologic’s Evaluation of Absorbable and Non-Absorbable Barrier Coated Mesh	243
Evaluation of Alginate Dialdehyde Cross-Linked Gelatin Hydrogel as a Biodegradable Sealant for Polyester Vascular Graft	244
Laparoscopic Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol Sealant in a Porcine Model	244
Evaluation of Fibrin Sealants for CNS Sealing in the Mongrel Dog Durotomy Model	245
Tissue Augmentation with Fibrin Sealant and Cultured Fibroblasts: A Preliminary Study	245
Effects of Fibrin, Thrombin, and Blood on Breast Capsule Formation in a Preclinical Model	246
Advantage of Spraying Fibrin Sealant on the Bleeding Site in pLPN	246
Importance of Fibrin Sealants in Laparoscopic Surgery	247
Comparative studies of TachoSil® and Sangustop®	248
Comparison of WS, CG, and FAST as Hemostats	248
Photopolymerised Gelatin made Highly Elastic Tissue Sealant	250
Experiment with PleuraSeal™ after Pulmonary Resections: A Study with Retrospective Case Matched Controls	251
Importance of Fibrin Sealant in Reducing Adhesion in IPOM Surgery for Hernia	251
Difference between new Fibrin Sealant and Standard Topical Hemostatic Agents	252
Fibrin Tissue Sealant to be Employed at the time of Laparoscopic Partial Nephrectomy	253
Efficiency of Fibrin Sealant in the Prevention of Gastrointestinal Anastomotic Leak	254
Fibrin Sealant to be employed as Hemostatic Agent after Liver Biopsy in Swine	255
Efficacy of the Fibrin Sealant Haemostasis on the Post-Operative Pain in case of Tonsillectomy	256
V. CORPORATE DIRECTORY	257
VI. PATENTS INFORMATION	268
VII. CLINICAL TRIALS	350