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Published: Oct, 2014 | Pages:
145 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Squamous Cell Carcinoma - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Squamous Cell Carcinoma - Pipeline Review, H2 2014', provides an overview of the Squamous Cell Carcinoma's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Squamous Cell Carcinoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Squamous Cell Carcinoma and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Squamous Cell Carcinoma - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Squamous Cell Carcinoma and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Squamous Cell Carcinoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Squamous Cell Carcinoma pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Squamous Cell Carcinoma - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Squamous Cell Carcinoma pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Squamous Cell Carcinoma Overview 9 Therapeutics Development 10 Pipeline Products for Squamous Cell Carcinoma - Overview 10 Pipeline Products for Squamous Cell Carcinoma - Comparative Analysis 11 Squamous Cell Carcinoma - Therapeutics under Development by Companies 12 Squamous Cell Carcinoma - Therapeutics under Investigation by Universities/Institutes 15 Squamous Cell Carcinoma - Pipeline Products Glance 16 Late Stage Products 16 Clinical Stage Products 17 Early Stage Products 18 Squamous Cell Carcinoma - Products under Development by Companies 19 Squamous Cell Carcinoma - Products under Investigation by Universities/Institutes 21 Squamous Cell Carcinoma - Companies Involved in Therapeutics Development 22 AbbVie Inc. 22 Axelar AB 23 Bexion Pharmaceuticals, LLC. 24 Boehringer Ingelheim GmbH 25 Celgene Corporation 26 Clinuvel Pharmaceuticals Limited 27 Eli Lilly and Company 28 G&E Herbal Biotechnology Co., Ltd. 29 Genextra S.p.a. 30 Genmab A/S 31 Hutchison MediPharma Limited 32 InMed Pharmaceuticals Inc. 33 Karyopharm Therapeutics, Inc. 34 Neotropix, Inc. 35 Omeros Corporation 36 Oncolytics Biotech Inc. 37 Onconova Therapeutics, Inc. 38 Oncovir, Inc. 39 Otsuka Holdings Co., Ltd. 40 Pfizer Inc. 41 Sanofi 42 Squamous Cell Carcinoma - Therapeutics Assessment 43 Assessment by Monotherapy Products 43 Assessment by Combination Products 44 Assessment by Target 45 Assessment by Mechanism of Action 48 Assessment by Route of Administration 51 Assessment by Molecule Type 53 Drug Profiles 55 afamelanotide - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 afatinib - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 AMXT-1501 + eflornithine hydrochloride - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 Antibody Drug Conjugate to Inhibit EFGR for Squamous Cell Tumor and Glioblastoma - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 AXL-1717 - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 boanmycin hydrochloride - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 BXQ-350 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 CIGB-128 - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 CS-S/BCC-1 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 CS-TATI-1 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 CUV-9900 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 DAC-0060 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 dacomitinib - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 HMPL-453 - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 LY-2606368 - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 NTX-500 - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 OPB-111001 - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 paclitaxel albumin bound - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 pelareorep - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 Poly-ICLC - Drug Profile 88 Product Description 88 Mechanism of Action 88 R&D Progress 88 rigosertib sodium - Drug Profile 90 Product Description 90 Mechanism of Action 90 R&D Progress 90 SAR-408701 - Drug Profile 94 Product Description 94 Mechanism of Action 94 R&D Progress 94 selinexor - Drug Profile 95 Product Description 95 Mechanism of Action 95 R&D Progress 95 Small Molecule to Antagonize GPR39 for Esophageal Squamous Cell Carcinoma and Obesity-Related Type-2 Diabetes - Drug Profile 98 Product Description 98 Mechanism of Action 98 R&D Progress 98 Small Molecule to Antagonize GPR87 for Cancer - Drug Profile 99 Product Description 99 Mechanism of Action 99 R&D Progress 99 Small Molecules for Cancer - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 Small Molecules to Inhibit PLK1 for Cutaneous Squamous Cell Carcinoma - Drug Profile 102 Product Description 102 Mechanism of Action 102 R&D Progress 102 SRT-100 - Drug Profile 103 Product Description 103 Mechanism of Action 103 R&D Progress 103 TF-011 Monomethyl Auristatin E - Drug Profile 105 Product Description 105 Mechanism of Action 105 R&D Progress 105 Squamous Cell Carcinoma - Recent Pipeline Updates 107 Squamous Cell Carcinoma - Dormant Projects 138 Squamous Cell Carcinoma - Discontinued Products 139 Squamous Cell Carcinoma - Product Development Milestones 140 Featured News & Press Releases 140 Sep 27, 2014: Head-to-head Phase III trial demonstrates superior progression-free survival for afatinib compared to erlotinib in patients with advanced squamous cell carcinoma of the lung 140 Mar 28, 2013: Oncolytics Biotech Meets Primary Overall Statistical Endpoint In US Phase II Study Of Reolysin In Squamous Cell Lung Cancer 141 Feb 08, 2013: Oncolytics Biotech Announces Additional Positive Reolysin Clinical Trial Data From Phase II Study In Squamous Cell Carcinoma Of Lung 142 Sep 24, 2012: Cannabis Science Initiates Preclinical Investigation Of CS-TATI-1 For European Studies For Squamous/Basal Cell Carcinomas And Kaposi's Sarcoma 142 Mar 30, 2010: Oncolytics Announces Start Of Enrollment In US Phase II SCC Lung Cancer Trial 143 Appendix 144 Methodology 144 Coverage 144 Secondary Research 144 Primary Research 144 Expert Panel Validation 144 Contact Us 145 Disclaimer 145
List of Tables Number of Products under Development for Squamous Cell Carcinoma, H2 2014 10 Number of Products under Development for Squamous Cell Carcinoma - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Development by Companies, H2 2014 (Contd..1) 14 Number of Products under Investigation by Universities/Institutes, H2 2014 15 Comparative Analysis by Late Stage Development, H2 2014 16 Comparative Analysis by Clinical Stage Development, H2 2014 17 Comparative Analysis by Early Stage Development, H2 2014 18 Products under Development by Companies, H2 2014 19 Products under Development by Companies, H2 2014 (Contd..1) 20 Products under Investigation by Universities/Institutes, H2 2014 21 Squamous Cell Carcinoma - Pipeline by AbbVie Inc., H2 2014 22 Squamous Cell Carcinoma - Pipeline by Axelar AB, H2 2014 23 Squamous Cell Carcinoma - Pipeline by Bexion Pharmaceuticals, LLC., H2 2014 24 Squamous Cell Carcinoma - Pipeline by Boehringer Ingelheim GmbH, H2 2014 25 Squamous Cell Carcinoma - Pipeline by Celgene Corporation, H2 2014 26 Squamous Cell Carcinoma - Pipeline by Clinuvel Pharmaceuticals Limited, H2 2014 27 Squamous Cell Carcinoma - Pipeline by Eli Lilly and Company, H2 2014 28 Squamous Cell Carcinoma - Pipeline by G&E Herbal Biotechnology Co., Ltd., H2 2014 29 Squamous Cell Carcinoma - Pipeline by Genextra S.p.a., H2 2014 30 Squamous Cell Carcinoma - Pipeline by Genmab A/S, H2 2014 31 Squamous Cell Carcinoma - Pipeline by Hutchison MediPharma Limited, H2 2014 32 Squamous Cell Carcinoma - Pipeline by InMed Pharmaceuticals Inc., H2 2014 33 Squamous Cell Carcinoma - Pipeline by Karyopharm Therapeutics, Inc., H2 2014 34 Squamous Cell Carcinoma - Pipeline by Neotropix, Inc., H2 2014 35 Squamous Cell Carcinoma - Pipeline by Omeros Corporation, H2 2014 36 Squamous Cell Carcinoma - Pipeline by Oncolytics Biotech Inc., H2 2014 37 Squamous Cell Carcinoma - Pipeline by Onconova Therapeutics, Inc., H2 2014 38 Squamous Cell Carcinoma - Pipeline by Oncovir, Inc., H2 2014 39 Squamous Cell Carcinoma - Pipeline by Otsuka Holdings Co., Ltd., H2 2014 40 Squamous Cell Carcinoma - Pipeline by Pfizer Inc., H2 2014 41 Squamous Cell Carcinoma - Pipeline by Sanofi, H2 2014 42 Assessment by Monotherapy Products, H2 2014 43 Assessment by Combination Products, H2 2014 44 Number of Products by Stage and Target, H2 2014 46 Number of Products by Stage and Mechanism of Action, H2 2014 49 Number of Products by Stage and Route of Administration, H2 2014 52 Number of Products by Stage and Molecule Type, H2 2014 54 Squamous Cell Carcinoma Therapeutics - Recent Pipeline Updates, H2 2014 107 Squamous Cell Carcinoma - Dormant Projects, H2 2014 138 Squamous Cell Carcinoma - Discontinued Products, H2 2014 139
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