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Published: Oct, 2014 | Pages:
224 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Soft Tissue Sarcoma - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Soft Tissue Sarcoma - Pipeline Review, H2 2014', provides an overview of the Soft Tissue Sarcoma's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Soft Tissue Sarcoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Soft Tissue Sarcoma and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Soft Tissue Sarcoma - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Soft Tissue Sarcoma and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Soft Tissue Sarcoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Soft Tissue Sarcoma pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Soft Tissue Sarcoma - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Soft Tissue Sarcoma pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Soft Tissue Sarcoma Overview 10 Therapeutics Development 11 Pipeline Products for Soft Tissue Sarcoma - Overview 11 Pipeline Products for Soft Tissue Sarcoma - Comparative Analysis 12 Soft Tissue Sarcoma - Therapeutics under Development by Companies 13 Soft Tissue Sarcoma - Therapeutics under Investigation by Universities/Institutes 15 Soft Tissue Sarcoma - Pipeline Products Glance 16 Late Stage Products 16 Clinical Stage Products 17 Early Stage Products 18 Unknown Stage Products 19 Soft Tissue Sarcoma - Products under Development by Companies 20 Soft Tissue Sarcoma - Products under Investigation by Universities/Institutes 22 Soft Tissue Sarcoma - Companies Involved in Therapeutics Development 23 A. Menarini Industrie Farmaceutiche Riunite Srl 23 Activartis Biotech GmbH 24 Advenchen Laboratories, LLC 25 Amgen Inc. 26 Bayer AG 27 Boehringer Ingelheim GmbH 28 CASI Pharmaceuticals Inc. 29 Celgene Corporation 30 CytRx Corporation 31 Eli Lilly and Company 32 Exelixis, Inc. 33 Gem Pharmaceuticals, LLC 34 GP Pharm, S.A. 35 Karyopharm Therapeutics, Inc. 36 MedImmune, LLC 37 Merck & Co., Inc. 38 MolMed S.p.A. 39 Morphotek, Inc. 40 Nanobiotix 41 Novartis AG 42 Oncos Therapeutics Ltd. 43 Onxeo SA 44 Pharma Mar, S.A. 45 Polaris Group 46 Recombio S.L 47 Sigma-Tau S.p.A. 48 Telik, Inc. 49 Threshold Pharmaceuticals, Inc. 50 Soft Tissue Sarcoma - Therapeutics Assessment 51 Assessment by Monotherapy Products 51 Assessment by Combination Products 52 Assessment by Target 53 Assessment by Mechanism of Action 56 Assessment by Route of Administration 58 Assessment by Molecule Type 60 Drug Profiles 62 AL-3818 - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 aldoxorubicin - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 AV0-113 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 belinostat - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 BI-853520 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 cabozantinib s-malate - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 celyvir - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 doxorubicin liposomal - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 durvalumab + tremelimumab - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 ENMD-2076 - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 everolimus - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 evofosfamide - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 ganitumab - Drug Profile 94 Product Description 94 Mechanism of Action 94 R&D Progress 94 GPX-150 - Drug Profile 97 Product Description 97 Mechanism of Action 97 R&D Progress 97 MVX-ONCO-1 - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 NBTX-TOPO - Drug Profile 101 Product Description 101 Mechanism of Action 101 R&D Progress 101 NBTXR-3 - Drug Profile 102 Product Description 102 Mechanism of Action 102 R&D Progress 102 NGR-hTNF - Drug Profile 104 Product Description 104 Mechanism of Action 104 R&D Progress 104 olaratumab - Drug Profile 108 Product Description 108 Mechanism of Action 108 R&D Progress 108 ONCOS-102 - Drug Profile 110 Product Description 110 Mechanism of Action 110 R&D Progress 110 ontuxizumab - Drug Profile 111 Product Description 111 Mechanism of Action 111 R&D Progress 111 paclitaxel albumin bound - Drug Profile 113 Product Description 113 Mechanism of Action 113 R&D Progress 113 panobinostat - Drug Profile 116 Product Description 116 Mechanism of Action 116 R&D Progress 116 Peptide to Target COX-2 and MAS-GPCR for Oncology - Drug Profile 122 Product Description 122 Mechanism of Action 122 R&D Progress 122 regorafenib - Drug Profile 124 Product Description 124 Mechanism of Action 124 R&D Progress 124 ridaforolimus - Drug Profile 127 Product Description 127 Mechanism of Action 127 R&D Progress 127 sabarubicin - Drug Profile 131 Product Description 131 Mechanism of Action 131 R&D Progress 131 selinexor - Drug Profile 133 Product Description 133 Mechanism of Action 133 R&D Progress 133 SST-0001 - Drug Profile 136 Product Description 136 Mechanism of Action 136 R&D Progress 136 TNF-PEG 20 - Drug Profile 137 Product Description 137 Mechanism of Action 137 R&D Progress 137 trabectedin - Drug Profile 138 Product Description 138 Mechanism of Action 138 R&D Progress 138 Vaccine for Cancer - Drug Profile 142 Product Description 142 Mechanism of Action 142 R&D Progress 142 Vaccine for Sarcoma - Drug Profile 143 Product Description 143 Mechanism of Action 143 R&D Progress 143 Soft Tissue Sarcoma - Recent Pipeline Updates 145 Soft Tissue Sarcoma - Dormant Projects 211 Soft Tissue Sarcoma - Discontinued Products 212 Soft Tissue Sarcoma - Product Development Milestones 213 Featured News & Press Releases 213 Oct 20, 2014: CytRx Announces Publication of Phase 1b/2 Aldoxorubicin Clinical Data in Soft Tissue Sarcoma in Cancer, the Peer-Reviewed Journal of the American Cancer Society 213 Oct 17, 2014: CytRx to Present Data from Global Phase 2b Clinical Trial of Aldoxorubicin in First-Line Soft Tissue Sarcoma at 2014 CTOS Annual Meeting 214 Oct 16, 2014: Nanobiotix Receives First Approval To Start Phase II/III Registration Trial In STS In Europe 215 Oct 08, 2014: PharmaEngine, Nanobiotix Enter Global Pivotal Trial of PEP503 (NBTXR3) in Soft Tissue Sarcoma 216 Sep 22, 2014: CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 217 Sep 22, 2014: Threshold Pharmaceuticals Announces Its Phase 3 Trial of TH-302 in Patients With Advanced Soft Tissue Sarcoma Will Continue as Planned Following Protocol-Specified Interim Analysis 218 Aug 07, 2014: Oral Presentation of CytRx's Aldoxorubicin Phase 2b Clinical Trial in Soft Tissue Sarcoma Highlighted in The Lancet Oncology 219 Jun 04, 2014: PharmaMar's partner Taiho Pharmaceutical presents at ASCO the results from the Phase 2 clinical trial of Yondelis in patients with Malignant Soft Tissue Sarcoma 220 Jun 02, 2014: Nanobiotix presents successful Phase I results for its lead nanomedicine product NBTXR3 at ASCO 221 May 28, 2014: CytRx Highlights Aldoxorubicin Data from its Global Phase 2b Clinical Trial in First-Line Soft Tissue Sarcoma 221 Appendix 223 Methodology 223 Coverage 223 Secondary Research 223 Primary Research 223 Expert Panel Validation 223 Contact Us 224 Disclaimer 224
List of Tables Number of Products under Development for Soft Tissue Sarcoma, H2 2014 11 Number of Products under Development for Soft Tissue Sarcoma - Comparative Analysis, H2 2014 12 Number of Products under Development by Companies, H2 2014 13 Number of Products under Investigation by Universities/Institutes, H2 2014 15 Comparative Analysis by Late Stage Development, H2 2014 16 Comparative Analysis by Clinical Stage Development, H2 2014 17 Comparative Analysis by Early Stage Development, H2 2014 18 Comparative Analysis by Unknown Stage Development, H2 2014 19 Products under Development by Companies, H2 2014 20 Products under Investigation by Universities/Institutes, H2 2014 22 Soft Tissue Sarcoma - Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl, H2 2014 23 Soft Tissue Sarcoma - Pipeline by Activartis Biotech GmbH, H2 2014 24 Soft Tissue Sarcoma - Pipeline by Advenchen Laboratories, LLC, H2 2014 25 Soft Tissue Sarcoma - Pipeline by Amgen Inc., H2 2014 26 Soft Tissue Sarcoma - Pipeline by Bayer AG, H2 2014 27 Soft Tissue Sarcoma - Pipeline by Boehringer Ingelheim GmbH, H2 2014 28 Soft Tissue Sarcoma - Pipeline by CASI Pharmaceuticals Inc., H2 2014 29 Soft Tissue Sarcoma - Pipeline by Celgene Corporation, H2 2014 30 Soft Tissue Sarcoma - Pipeline by CytRx Corporation, H2 2014 31 Soft Tissue Sarcoma - Pipeline by Eli Lilly and Company, H2 2014 32 Soft Tissue Sarcoma - Pipeline by Exelixis, Inc., H2 2014 33 Soft Tissue Sarcoma - Pipeline by Gem Pharmaceuticals, LLC, H2 2014 34 Soft Tissue Sarcoma - Pipeline by GP Pharm, S.A., H2 2014 35 Soft Tissue Sarcoma - Pipeline by Karyopharm Therapeutics, Inc., H2 2014 36 Soft Tissue Sarcoma - Pipeline by MedImmune, LLC, H2 2014 37 Soft Tissue Sarcoma - Pipeline by Merck & Co., Inc., H2 2014 38 Soft Tissue Sarcoma - Pipeline by MolMed S.p.A., H2 2014 39 Soft Tissue Sarcoma - Pipeline by Morphotek, Inc., H2 2014 40 Soft Tissue Sarcoma - Pipeline by Nanobiotix, H2 2014 41 Soft Tissue Sarcoma - Pipeline by Novartis AG, H2 2014 42 Soft Tissue Sarcoma - Pipeline by Oncos Therapeutics Ltd., H2 2014 43 Soft Tissue Sarcoma - Pipeline by Onxeo SA, H2 2014 44 Soft Tissue Sarcoma - Pipeline by Pharma Mar, S.A., H2 2014 45 Soft Tissue Sarcoma - Pipeline by Polaris Group, H2 2014 46 Soft Tissue Sarcoma - Pipeline by Recombio S.L, H2 2014 47 Soft Tissue Sarcoma - Pipeline by Sigma-Tau S.p.A., H2 2014 48 Soft Tissue Sarcoma - Pipeline by Telik, Inc., H2 2014 49 Soft Tissue Sarcoma - Pipeline by Threshold Pharmaceuticals, Inc., H2 2014 50 Assessment by Monotherapy Products, H2 2014 51 Assessment by Combination Products, H2 2014 52 Number of Products by Stage and Target, H2 2014 54 Number of Products by Stage and Mechanism of Action, H2 2014 57 Number of Products by Stage and Route of Administration, H2 2014 59 Number of Products by Stage and Molecule Type, H2 2014 61 Soft Tissue Sarcoma Therapeutics - Recent Pipeline Updates, H2 2014 145 Soft Tissue Sarcoma - Dormant Projects, H2 2014 211 Soft Tissue Sarcoma - Discontinued Products, H2 2014 212
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