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Published: Jun, 2016 | Pages:
58 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Pipeline Review, H1 2016 Summary Global Markets Direct's, 'RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Pipeline Review, H1 2016', provides in depth analysis on RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted pipeline therapeutics. The report provides comprehensive information on the RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted therapeutics development and features dormant and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data. Scope - The report provides a snapshot of the global therapeutic landscape for RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - The report reviews RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted therapeutics and enlists all their major and minor projects - The report assesses RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type - The report summarizes all the dormant and discontinued pipeline projects - The report reviews latest news and deals related to RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) targeted therapeutics Reasons To Buy - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Identify and understand the targeted therapy areas and indications for RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Identify the use of drugs for target identification and drug repurposing - Identify potential new clients or partners in the target demographic - Develop strategic initiatives by understanding the focus areas of leading companies - Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics - Devise corrective measures for pipeline projects by understanding RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) development landscape - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
Table of Contents 2 List of Tables 4 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) Overview 7 Therapeutics Development 8 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Products under Development by Stage of Development 8 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Products under Development by Therapy Area 9 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Products under Development by Indication 10 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Pipeline Products Glance 12 Late Stage Products 12 Early Stage Products 13 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Products under Development by Companies 14 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Therapeutics Assessment 18 Assessment by Monotherapy/Combination Products 18 Assessment by Mechanism of Action 19 Assessment by Route of Administration 20 Assessment by Molecule Type 22 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Companies Involved in Therapeutics Development 23 ArQule, Inc. 23 AstraZeneca Plc 24 Cipher Pharmaceuticals Inc. 25 Merck & Co., Inc. 26 Novartis AG 28 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Drug Profiles 29 ARQ-092 - Drug Profile 29 Product Description 29 Mechanism Of Action 29 R&D Progress 29 AZD-5363 - Drug Profile 32 Product Description 32 Mechanism Of Action 32 R&D Progress 32 ISC-4 - Drug Profile 34 Product Description 34 Mechanism Of Action 34 R&D Progress 34 JRP-890 - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 MK-2206 - Drug Profile 36 Product Description 36 Mechanism Of Action 36 R&D Progress 36 MK-2206 + selumetinib sulfate - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 trametinib dimethyl sulfoxide + uprosertib - Drug Profile 40 Product Description 40 Mechanism Of Action 40 R&D Progress 40 uprosertib - Drug Profile 42 Product Description 42 Mechanism Of Action 42 R&D Progress 42 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Dormant Projects 43 RAC-Gamma Serine/Threonine-Protein Kinase (Akt-3 or Protein Kinase Akt-3 or Protein Kinase B Gamma or RAC-PK-Gamma or STK-2 or EC 2.7.11.1) - Featured News & Press Releases 46 Jan 28, 2016: ArQule Provides Update on ARQ 092 46 Nov 17, 2015: ArQule and the National Human Genome Research Institute of the National Institutes of Health Announce Enrollment of First Patient in the Phase 1 Proteus Syndrome Trial With ARQ 092 46 Nov 08, 2015: BIND Presents Data on MK-2206, at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 48 Oct 26, 2015: BIND Therapeutics' Presentation at Upcoming AACR-NCI-EORTC Conference Reinforce Potential of Accurin Platform to Develop Best-in-Class Therapeutics 49 Oct 15, 2015: ArQule Announces Publication of Manuscript Highlighting Activity of AKT Inhibitor ARQ 092 in Oncology 49 Sep 28, 2015: ArQule Presents Results From Phase 1b Expansion Study of ARQ 092 at the 2015 European Cancer Conference 50 Nov 13, 2014: ArQule Announces Data Presentations on ARQ 092 at 26th EORTC-NCI-AACR Symposium 51 Nov 11, 2014: ArQule Announces Collaboration with NIH for Clinical Development of ARQ 092 in Proteus Syndrome 52 Oct 21, 2013: New Drug Combinations May Benefit Patients With Pancreatic Cancer 52 Apr 09, 2013: ArQule's New AKT Pathway Inhibitor, ARQ 092, Demonstrates Safety, Target Inhibition in Phase I Trial 53 Apr 07, 2013: AstraZeneca's AKT Inhibitor AZD5363 Well Tolerated, Yieldes Partial Response In Patients With Advanced Solid Tumors, Phase I Study Finds 54 Nov 10, 2011: Daiichi Sankyo To License ARQ 092 From ArQule, The First New Compound Resulting From The Companies' Joint AKIP Research Collaboration 55 Apr 12, 2011: Astex Announces Commencement Of Phase I Study For AZD5363 In Anti-Cancer Collaboration With AstraZeneca 56 Jun 01, 2009: AstraZeneca and Merck & Co., Inc. Form Pioneering Collaboration to Investigate Novel Combination Anticancer Regimen 56 Appendix 57 Methodology 57 Coverage 57 Secondary Research 57 Primary Research 57 Expert Panel Validation 57 Contact Us 57 Disclaimer 58
List of Tables
Number of Products under Development for, H1 2016 8 Number of Products under Development by Therapy Area, H1 2016 9 Number of Products under Development by Indication, H1 2016 10 Comparative Analysis by Late Stage Development, H1 2016 12 Comparative Analysis by Early Stage Products, H1 2016 13 Number of Products under Development by Companies, H1 2016 14 Products under Development by Companies, H1 2016 15 Products under Development by Companies, H1 2016 (Contd..1) 16 Products under Development by Companies, H1 2016 (Contd..2) 17 Assessment by Monotherapy/Combination Products, H1 2016 18 Number of Products by Stage and Mechanism of Action, H1 2016 19 Number of Products by Stage and Route of Administration, H1 2016 21 Number of Products by Stage and Molecule Type, H1 2016 22 Pipeline by ArQule, Inc., H1 2016 23 Pipeline by AstraZeneca Plc, H1 2016 24 Pipeline by Cipher Pharmaceuticals Inc., H1 2016 25 Pipeline by Merck & Co., Inc., H1 2016 26 Pipeline by Novartis AG, H1 2016 28 Dormant Projects, H1 2016 43 Dormant Projects (Contd..1), H1 2016 44 Dormant Projects (Contd..2), H1 2016 45
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