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Published: Sep, 2014 | Pages:
94 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Pruritus - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Pruritus - Pipeline Review, H2 2014', provides an overview of the Pruritus's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Pruritus, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Pruritus and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Pruritus - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Pruritus and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Pruritus products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Pruritus pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Pruritus - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Pruritus pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Pruritus Overview 9 Therapeutics Development 10 Pipeline Products for Pruritus - Overview 10 Pipeline Products for Pruritus - Comparative Analysis 11 Pruritus - Therapeutics under Development by Companies 12 Pruritus - Therapeutics under Investigation by Universities/Institutes 14 Pruritus - Pipeline Products Glance 15 Late Stage Products 15 Clinical Stage Products 16 Early Stage Products 17 Pruritus - Products under Development by Companies 18 Pruritus - Products under Investigation by Universities/Institutes 19 Pruritus - Companies Involved in Therapeutics Development 20 Johnson & Johnson 20 Shionogi & Co., Ltd. 21 GlaxoSmithKline plc 22 Merck & Co., Inc. 23 Santen Pharmaceutical Co., Ltd. 24 Amorepacific Corporation 25 LEO Pharma A/S 26 Nippon Shinyaku Co., Ltd. 27 RDD Pharma Ltd. 28 Toray Industries, Inc. 29 FAES Farma SA 30 Hydra Biosciences, Inc. 31 Cara Therapeutics, Inc. 32 ELORAC, Inc. 33 Vanda Pharmaceuticals Inc. 34 Creabilis SA 35 Trevi Therapeutics, Inc. 36 Conrig Pharma ApS 37 NeRRe Therapeutics Ltd 38 Pruritus - Therapeutics Assessment 39 Assessment by Monotherapy Products 39 Assessment by Target 40 Assessment by Mechanism of Action 43 Assessment by Route of Administration 46 Assessment by Molecule Type 48 Drug Profiles 50 bilastine - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 desloratadine - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 naloxone hydrochloride - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 nalbuphine hydrochloride ER - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 orvepitant maleate - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 CT-327 - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 CR-845 - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 nalfurafine hydrochloride - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 NS-141 - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 VLY-686 - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 PAC-14028 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 Small Molecule for Pruritus - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 serlopitant - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 aprepitant - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 GSK-2330672 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 Small Molecules to Inhibit TRPV3 for Pain, Pruritus and Psoriasis - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 JNJ-7777120 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 Small Molecule to Agonize CB2 for Pruritus - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 Drugs to Target Mas-Related G-Protein Coupled Receptor for Pruritus - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 SA-14867 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 CRG-010 - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 PP-120 - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 Pruritus - Recent Pipeline Updates 78 Pruritus - Dormant Projects 85 Pruritus - Discontinued Products 86 Pruritus - Product Development Milestones 87 Featured News & Press Releases 87 Mar 21, 2014: Creabilis to Present CT327 Phase 2b Data at American Academy of Dermatology Annual Meeting 87 Jan 23, 2014: Start of Phase II study of neurokinin-1 receptor antagonist orvepitant for intense pruritus induced by epidermal growth factor receptor inhibitors 88 Aug 19, 2013: Velocity Pharmaceutical Development and Tigercat Pharma Announce Submission of IND Application for VPD-737 89 Apr 12, 2013: Elorac's Naloxone Topical Lotion Receives FDA Fast Track Designation For Relief Of Pruritus In Patients With Cutaneous T-cell Lymphoma 89 Dec 22, 2011: Toray, Japan Tobacco And Torii Terminate Joint Development Of Nalfurafine Hydrochloride For Pruritus Associated With Liver Disease In Japan 90 Jul 21, 2011: Merz Aesthetics Announces FDA Approval Of XEOMIN For Temporary Improvement In Appearance Of Moderate To Severe Glabellar Lines In Adult Patients 90 Nov 30, 2010: Elorac Wins Orphan Drug Designation For Naloxone For Treatment Of Pruritus In Cutaneous T-Cell Lymphoma 90 Mar 23, 2009: Torii Pharma To Launch Remitch Capsules 2.5�g For Hemodialysis Patients 91 Jan 21, 2009: Toray Announces Manufacturing And Marketing Approval For Remitch Capsules 2.5�g In Japan 91 Apr 27, 2007: Schering-Plough declared EU Approval of Two New Formulations of AERIUS(Desloratadine). 91 Appendix 93 Methodology 93 Coverage 93 Secondary Research 93 Primary Research 93 Expert Panel Validation 93 Contact Us 94 Disclaimer 94
List of Tables Number of Products under Development for Pruritus, H2 2014 10 Number of Products under Development for Pruritus - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Investigation by Universities/Institutes, H2 2014 14 Comparative Analysis by Late Stage Development, H2 2014 15 Comparative Analysis by Clinical Stage Development, H2 2014 16 Comparative Analysis by Early Stage Development, H2 2014 17 Products under Development by Companies, H2 2014 18 Products under Investigation by Universities/Institutes, H2 2014 19 Pruritus - Pipeline by Johnson & Johnson, H2 2014 20 Pruritus - Pipeline by Shionogi & Co., Ltd., H2 2014 21 Pruritus - Pipeline by GlaxoSmithKline plc, H2 2014 22 Pruritus - Pipeline by Merck & Co., Inc., H2 2014 23 Pruritus - Pipeline by Santen Pharmaceutical Co., Ltd., H2 2014 24 Pruritus - Pipeline by Amorepacific Corporation, H2 2014 25 Pruritus - Pipeline by LEO Pharma A/S, H2 2014 26 Pruritus - Pipeline by Nippon Shinyaku Co., Ltd., H2 2014 27 Pruritus - Pipeline by RDD Pharma Ltd., H2 2014 28 Pruritus - Pipeline by Toray Industries, Inc., H2 2014 29 Pruritus - Pipeline by FAES Farma SA, H2 2014 30 Pruritus - Pipeline by Hydra Biosciences, Inc., H2 2014 31 Pruritus - Pipeline by Cara Therapeutics, Inc., H2 2014 32 Pruritus - Pipeline by ELORAC, Inc., H2 2014 33 Pruritus - Pipeline by Vanda Pharmaceuticals Inc., H2 2014 34 Pruritus - Pipeline by Creabilis SA, H2 2014 35 Pruritus - Pipeline by Trevi Therapeutics, Inc., H2 2014 36 Pruritus - Pipeline by Conrig Pharma ApS, H2 2014 37 Pruritus - Pipeline by NeRRe Therapeutics Ltd, H2 2014 38 Assessment by Monotherapy Products, H2 2014 39 Number of Products by Stage and Target, H2 2014 42 Number of Products by Stage and Mechanism of Action, H2 2014 45 Number of Products by Stage and Route of Administration, H2 2014 47 Number of Products by Stage and Molecule Type, H2 2014 49 Pruritus Therapeutics - Recent Pipeline Updates, H2 2014 78 Pruritus - Dormant Projects, H2 2014 85 Pruritus - Discontinued Products, H2 2014 86
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