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Published: Aug, 2014 | Pages:
97 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline Review, H2 2014', provides an overview of the Post-Polycythemia Vera Myelofibrosis (PPV-MF)'s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Post-Polycythemia Vera Myelofibrosis (PPV-MF), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Post-Polycythemia Vera Myelofibrosis (PPV-MF) and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Post-Polycythemia Vera Myelofibrosis (PPV-MF) - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Post-Polycythemia Vera Myelofibrosis (PPV-MF) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Post-Polycythemia Vera Myelofibrosis (PPV-MF) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Post-Polycythemia Vera Myelofibrosis (PPV-MF) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Post-Polycythemia Vera Myelofibrosis (PPV-MF) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Post-Polycythemia Vera Myelofibrosis (PPV-MF) Overview 7 Therapeutics Development 8 Pipeline Products for Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Overview 8 Pipeline Products for Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Comparative Analysis 9 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Therapeutics under Development by Companies 10 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline Products Glance 11 Late Stage Products 11 Clinical Stage Products 12 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Products under Development by Companies 13 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Companies Involved in Therapeutics Development 14 AstraZeneca PLC 14 Gilead Sciences, Inc. 15 Novartis AG 16 Nippon Shinyaku Co., Ltd. 17 CTI BioPharma Corp. 18 Incyte Corporation 19 Italfarmaco S.p.A. 20 Promedior, Inc. 21 Pharma Mar, S.A. 22 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Therapeutics Assessment 23 Assessment by Monotherapy Products 23 Assessment by Target 24 Assessment by Mechanism of Action 26 Assessment by Route of Administration 28 Assessment by Molecule Type 30 Drug Profiles 32 pacritinib - Drug Profile 32 Product Description 32 Mechanism of Action 32 R&D Progress 32 momelotinib - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 ruxolitinib phosphate - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 PRM-151 - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 plitidepsin - Drug Profile 42 Product Description 42 Mechanism of Action 42 R&D Progress 42 LCL-161 - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 luminespib - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 givinostat - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 simtuzumab - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 INCB-39110 - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 AZD-1480 - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 panobinostat - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 NS-018 - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 buparlisib hydrochloride - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Recent Pipeline Updates 67 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Discontinued Products 91 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Product Development Milestones 92 Featured News & Press Releases 92 Dec 07, 2012: Incyte Announces Presentation Of New Data For Jakafi At 2012 American Society Of Hematology Annual Meeting 92 Aug 28, 2012: Incyte's Partner Novartis Receives European Approval For Jakavi 93 Jun 04, 2012: Incyte Presents New Clinical Data Of Jakafi At ASCO 2012 Annual Meeting 93 Apr 20, 2012: Incyte Announces EU Regulatory Milestone From Novartis For Ruxolitinib 95 Appendix 96 Methodology 96 Coverage 96 Secondary Research 96 Primary Research 96 Expert Panel Validation 96 Contact Us 97 Disclaimer 97
List of Tables Number of Products under Development for Post-Polycythemia Vera Myelofibrosis (PPV-MF), H2 2014 8 Number of Products under Development for Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Comparative Analysis, H2 2014 9 Number of Products under Development by Companies, H2 2014 10 Comparative Analysis by Late Stage Development, H2 2014 11 Comparative Analysis by Clinical Stage Development, H2 2014 12 Products under Development by Companies, H2 2014 13 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by AstraZeneca PLC, H2 2014 14 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Gilead Sciences, Inc., H2 2014 15 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Novartis AG, H2 2014 16 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Nippon Shinyaku Co., Ltd., H2 2014 17 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by CTI BioPharma Corp., H2 2014 18 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Incyte Corporation, H2 2014 19 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Italfarmaco S.p.A., H2 2014 20 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Promedior, Inc., H2 2014 21 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Pipeline by Pharma Mar, S.A., H2 2014 22 Assessment by Monotherapy Products, H2 2014 23 Number of Products by Stage and Target, H2 2014 25 Number of Products by Stage and Mechanism of Action, H2 2014 27 Number of Products by Stage and Route of Administration, H2 2014 29 Number of Products by Stage and Molecule Type, H2 2014 31 Post-Polycythemia Vera Myelofibrosis (PPV-MF) Therapeutics - Recent Pipeline Updates, H2 2014 67 Post-Polycythemia Vera Myelofibrosis (PPV-MF) - Discontinued Products, H2 2014 91
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