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Published: Jan, 2015 | Pages:
83 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2015 Summary Global Markets Direct's, 'Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2015', provides an overview of the Opioid-Induced Constipation (OIC)'s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Opioid-Induced Constipation (OIC), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Opioid-Induced Constipation (OIC) and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Opioid-Induced Constipation (OIC) - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Opioid-Induced Constipation (OIC) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Opioid-Induced Constipation (OIC) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Opioid-Induced Constipation (OIC) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons To Buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Opioid-Induced Constipation (OIC) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Opioid-Induced Constipation (OIC) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Opioid-Induced Constipation (OIC) Overview 7 Therapeutics Development 8 Pipeline Products for Opioid-Induced Constipation (OIC) - Overview 8 Pipeline Products for Opioid-Induced Constipation (OIC) - Comparative Analysis 9 Opioid-Induced Constipation (OIC) - Therapeutics under Development by Companies 10 Opioid-Induced Constipation (OIC) - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Opioid-Induced Constipation (OIC) - Products under Development by Companies 14 Opioid-Induced Constipation (OIC) - Companies Involved in Therapeutics Development 15 AstraZeneca PLC 15 Cosmo Pharmaceuticals S.p.A 16 Cubist Pharmaceuticals, Inc. 17 Develco Pharma Schweiz AG 18 Ironwood Pharmaceuticals, Inc. 19 S.L.A. Pharma AG 20 Salix Pharmaceuticals Ltd. 21 Shionogi & Co., Ltd. 22 Sucampo Pharmaceuticals, Inc. 23 Synergy Pharmaceuticals, Inc. 24 Opioid-Induced Constipation (OIC) - Therapeutics Assessment 25 Assessment by Monotherapy Products 25 Assessment by Target 26 Assessment by Mechanism of Action 28 Assessment by Route of Administration 30 Assessment by Molecule Type 32 Drug Profiles 34 axelopran - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 bevenopran - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 linaclotide - Drug Profile 38 Product Description 38 Mechanism of Action 38 R&D Progress 38 lubiprostone - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 methylnaltrexone bromide - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 naldemedine - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 naloxegol oxalate - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 naloxone hydrochloride - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 naloxone hydrochloride PR - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 naloxone hydrochloride SR - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 SP-333 - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 Opioid-Induced Constipation (OIC) - Recent Pipeline Updates 53 Opioid-Induced Constipation (OIC) - Dormant Projects 72 Opioid-Induced Constipation (OIC) - Discontinued Products 73 Opioid-Induced Constipation (OIC) - Product Development Milestones 74 Featured News & Press Releases 74 Dec 30, 2014: Sucampo Announces Acceptance of New Drug Submission for AMITIZA (lubiprostone) by Health Canada 74 Dec 09, 2014: MOVENTIG approved in the European Union for opioid-induced constipation 74 Nov 19, 2014: Synergy Pharmaceuticals Announces Positive Results of SP-333 Phase 2 Trial in Patients with Opioid-Induced Constipation 75 Oct 16, 2014: Ironwood Pharmaceuticals Announces Initiation of Phase II Trial of Linaclotide in Adult Patients with Opioid-Induced Constipation 76 Oct 13, 2014: Clinical Data for AMITIZA Lubiprostone to be Presented at the American College of Gastroenterology 2014 Annual Scientific Meeting 77 Oct 06, 2014: Progenics Receives $40 Million Milestone Following FDA Approval of RELISTOR for OIC Patients With Chronic Non-Cancer Pain 77 Sep 29, 2014: Sucampo and Takeda Launch Direct-to-Consumer Advertising Campaign for AMITIZA (lubiprostone) for Chronic Idiopathic Constipation 78 Sep 29, 2014: FDA Approves RELISTOR Subcutaneous Injection for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-cancer Pain 79 Sep 26, 2014: MOVENTIG (naloxegol) receives positive CHMP opinion in the EU for the treatment of adults with opioid-induced constipation 80 Sep 16, 2014: FDA Approves MOVANTIK (naloxegol) Tablets C-II for the Treatment of Opioid-Induced Constipation in Adult Patients with Chronic Non-Cancer Pain 81 Appendix 82 Methodology 82 Coverage 82 Secondary Research 82 Primary Research 82 Expert Panel Validation 82 Contact Us 83 Disclaimer 83
List of Tables Number of Products under Development for Opioid-Induced Constipation (OIC), H1 2015 8 Number of Products under Development for Opioid-Induced Constipation (OIC) - Comparative Analysis, H1 2015 9 Number of Products under Development by Companies, H1 2015 11 Comparative Analysis by Late Stage Development, H1 2015 12 Comparative Analysis by Clinical Stage Development, H1 2015 13 Products under Development by Companies, H1 2015 14 Opioid-Induced Constipation (OIC) - Pipeline by AstraZeneca PLC, H1 2015 15 Opioid-Induced Constipation (OIC) - Pipeline by Cosmo Pharmaceuticals S.p.A, H1 2015 16 Opioid-Induced Constipation (OIC) - Pipeline by Cubist Pharmaceuticals, Inc., H1 2015 17 Opioid-Induced Constipation (OIC) - Pipeline by Develco Pharma Schweiz AG, H1 2015 18 Opioid-Induced Constipation (OIC) - Pipeline by Ironwood Pharmaceuticals, Inc., H1 2015 19 Opioid-Induced Constipation (OIC) - Pipeline by S.L.A. Pharma AG, H1 2015 20 Opioid-Induced Constipation (OIC) - Pipeline by Salix Pharmaceuticals Ltd., H1 2015 21 Opioid-Induced Constipation (OIC) - Pipeline by Shionogi & Co., Ltd., H1 2015 22 Opioid-Induced Constipation (OIC) - Pipeline by Sucampo Pharmaceuticals, Inc., H1 2015 23 Opioid-Induced Constipation (OIC) - Pipeline by Synergy Pharmaceuticals, Inc., H1 2015 24 Assessment by Monotherapy Products, H1 2015 25 Number of Products by Stage and Target, H1 2015 27 Number of Products by Stage and Mechanism of Action, H1 2015 29 Number of Products by Stage and Route of Administration, H1 2015 31 Number of Products by Stage and Molecule Type, H1 2015 33 Opioid-Induced Constipation (OIC) Therapeutics - Recent Pipeline Updates, H1 2015 53 Opioid-Induced Constipation (OIC) - Dormant Projects, H1 2015 72 Opioid-Induced Constipation (OIC) - Discontinued Products, H1 2015 73
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