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Published: Feb, 2016 | Pages:
134 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline Review, H1 2016 Summary Global Markets Direct's, 'Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline Review, H1 2016', provides an overview of the Non Alcoholic Fatty Liver Disease (NAFLD) pipeline landscape. The report provides comprehensive information on the therapeutics under development for Non Alcoholic Fatty Liver Disease (NAFLD), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Non Alcoholic Fatty Liver Disease (NAFLD) and features dormant and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data. Scope - The report provides a snapshot of the global therapeutic landscape of Non Alcoholic Fatty Liver Disease (NAFLD) - The report reviews pipeline therapeutics for Non Alcoholic Fatty Liver Disease (NAFLD) by companies and universities/research institutes based on information derived from company and industry-specific sources - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved Non Alcoholic Fatty Liver Disease (NAFLD) therapeutics and enlists all their major and minor projects - The report assesses Non Alcoholic Fatty Liver Disease (NAFLD) therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type - The report summarizes all the dormant and discontinued pipeline projects - The report reviews latest news related to pipeline therapeutics for Non Alcoholic Fatty Liver Disease (NAFLD) Reasons to Buy - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Identify and understand important and diverse types of therapeutics under development for Non Alcoholic Fatty Liver Disease (NAFLD) - Identify potential new clients or partners in the target demographic - Develop strategic initiatives by understanding the focus areas of leading companies - Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics - Devise corrective measures for pipeline projects by understanding Non Alcoholic Fatty Liver Disease (NAFLD) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and Scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Non Alcoholic Fatty Liver Disease (NAFLD) Overview 10 Therapeutics Development 11 Pipeline Products for Non Alcoholic Fatty Liver Disease (NAFLD) - Overview 11 Pipeline Products for Non Alcoholic Fatty Liver Disease (NAFLD) - Comparative Analysis 12 Non Alcoholic Fatty Liver Disease (NAFLD) - Therapeutics under Development by Companies 13 Non Alcoholic Fatty Liver Disease (NAFLD) - Therapeutics under Investigation by Universities/Institutes 15 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline Products Glance 16 Late Stage Products 16 Clinical Stage Products 17 Early Stage Products 18 Non Alcoholic Fatty Liver Disease (NAFLD) - Products under Development by Companies 19 Non Alcoholic Fatty Liver Disease (NAFLD) - Products under Investigation by Universities/Institutes 21 Non Alcoholic Fatty Liver Disease (NAFLD) - Companies Involved in Therapeutics Development 22 Arisaph Pharmaceuticals, Inc. 22 AstraZeneca Plc 23 Betagenon AB 24 Can-Fite BioPharma Ltd. 25 Conatus Pharmaceuticals Inc. 26 Corcept Therapeutics Incorporated 27 Daewoong Pharmaceutical Co., Ltd. 28 Dimerix Bioscience Pty Ltd 29 Dr. Falk Pharma GmbH 30 DURECT Corporation 31 Galmed Pharmaceuticals Ltd. 32 Gilead Sciences, Inc. 33 Huons Co., Ltd. 34 Kyorin Pharmaceutical Co., Ltd. 35 Novartis AG 36 Sancilio & Company, Inc. 37 TaiwanJ Pharmaceuticals Co., Ltd. 38 TCM Biotech International Corp 39 Tobira Therapeutics, Inc. 40 Verva Pharmaceuticals Limited 41 Zafgen Inc. 42 Zydus Cadila Healthcare Limited 43 Non Alcoholic Fatty Liver Disease (NAFLD) - Therapeutics Assessment 44 Assessment by Monotherapy Products 44 Assessment by Combination Products 45 Assessment by Target 46 Assessment by Mechanism of Action 49 Assessment by Route of Administration 51 Assessment by Molecule Type 53 Drug Profiles 54 (leucine + metformin hydrochloride + sildenafil citrate) - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 (leucine + PDE5 Inhibitor) - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 Aramchol - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 ARI-3037MO - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 C-10 - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 cenicriviroc mesylate - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 CF-102 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 CORT-118335 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 DMX-300 - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 Drugs to Inhibit ABHD6 for Gastrointestinal and Metabolic Disorders - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 DUR-928 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 DWP-10292 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 emricasan - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 FLB-12 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 GS-9674 - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 HU-002 - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 KDT-501 - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 MAT-8800 - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 methazolamide - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 MN-002 - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 naltrexone hydrochloride - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 norursodeoxycholic acid - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 O-304 - Drug Profile 89 Product Description 89 Mechanism of Action 89 R&D Progress 89 oltipraz - Drug Profile 91 Product Description 91 Mechanism of Action 91 R&D Progress 91 pradigastat sodium - Drug Profile 92 Product Description 92 Mechanism of Action 92 R&D Progress 92 Px-103 - Drug Profile 93 Product Description 93 Mechanism of Action 93 R&D Progress 93 saroglitazar - Drug Profile 94 Product Description 94 Mechanism of Action 94 R&D Progress 94 SC-410 - Drug Profile 95 Product Description 95 Mechanism of Action 95 R&D Progress 95 Small Molecule for Non-Alcoholic Steatohepatitis and Non-Alcoholic Fatty Liver Disease - Drug Profile 96 Product Description 96 Mechanism of Action 96 R&D Progress 96 Small Molecules to Activate AMPK for Fatty Liver Disease - Drug Profile 97 Product Description 97 Mechanism of Action 97 R&D Progress 97 Small Molecules to Inhibit NaCT for Metabolic Diseases - Drug Profile 98 Product Description 98 Mechanism of Action 98 R&D Progress 98 TCM-606F - Drug Profile 99 Product Description 99 Mechanism of Action 99 R&D Progress 99 VVP-100-X - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 ZGN-839 - Drug Profile 101 Product Description 101 Mechanism of Action 101 R&D Progress 101 Non Alcoholic Fatty Liver Disease (NAFLD) - Recent Pipeline Updates 102 Non Alcoholic Fatty Liver Disease (NAFLD) - Dormant Projects 122 Non Alcoholic Fatty Liver Disease (NAFLD) - Discontinued Products 123 Non Alcoholic Fatty Liver Disease (NAFLD) - Product Development Milestones 124 Featured News & Press Releases 124 Jan 11, 2016: Can-Fite Announces Update on CF102 124 Jan 06, 2016: DURECT Announces Positive Phase 1 Data for DUR-928 124 Dec 10, 2015: NuSirt Biopharma Receives FDA Fast Track Designation for Non-Alcoholic Fatty Liver Disease Treatment 125 Dec 01, 2015: Galmed Pharmaceuticals Announces FDA Clearance of IND of Aramachol for the Treatment of Patients with HIV-Associated Lipodystrophy and Nonalcoholic Fatty Liver Disease 126 Oct 08, 2015: NuSirt Biopharma Plans Clinical Trial in Non-Alcoholic Fatty Liver Disease 126 May 18, 2015: DURECT Announces Positive Results from DUR-928 Multi-Dose Phase 1 Study 127 Apr 23, 2015: Conatus Clinical Results at EASL Meeting Support Emricasan Registration Pathway in NASH 128 Apr 08, 2015: Conatus Pharmaceuticals to Present Three Emricasan Clinical Results Posters at EASL Meeting 129 Mar 30, 2015: DURECT Announces Initiation of DUR-928 Multi-Dose Phase 1 Study 130 Mar 26, 2015: Conatus Announces Successful Top-Line Results From NAFLD/NASH Clinical Trial of Emricasan 131 Appendix 133 Methodology 133 Coverage 133 Secondary Research 133 Primary Research 133 Expert Panel Validation 133 Contact Us 133 Disclaimer 134
List of Tables Number of Products under Development for Non Alcoholic Fatty Liver Disease (NAFLD), H1 2016 11 Number of Products under Development for Non Alcoholic Fatty Liver Disease (NAFLD) - Comparative Analysis, H1 2016 12 Number of Products under Development by Companies, H1 2016 13 Number of Products under Development by Companies, H1 2016 (Contd..1) 14 Number of Products under Investigation by Universities/Institutes, H1 2016 15 Comparative Analysis by Late Stage Development, H1 2016 16 Comparative Analysis by Clinical Stage Development, H1 2016 17 Comparative Analysis by Early Stage Development, H1 2016 18 Products under Development by Companies, H1 2016 19 Products under Development by Companies, H1 2016 (Contd..1) 20 Products under Investigation by Universities/Institutes, H1 2016 21 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Arisaph Pharmaceuticals, Inc., H1 2016 22 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by AstraZeneca Plc, H1 2016 23 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Betagenon AB, H1 2016 24 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Can-Fite BioPharma Ltd., H1 2016 25 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Conatus Pharmaceuticals Inc., H1 2016 26 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Corcept Therapeutics Incorporated, H1 2016 27 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Daewoong Pharmaceutical Co., Ltd., H1 2016 28 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Dimerix Bioscience Pty Ltd, H1 2016 29 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Dr. Falk Pharma GmbH, H1 2016 30 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by DURECT Corporation, H1 2016 31 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Galmed Pharmaceuticals Ltd., H1 2016 32 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Gilead Sciences, Inc., H1 2016 33 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Huons Co., Ltd., H1 2016 34 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Kyorin Pharmaceutical Co., Ltd., H1 2016 35 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Novartis AG, H1 2016 36 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Sancilio & Company, Inc., H1 2016 37 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by TaiwanJ Pharmaceuticals Co., Ltd., H1 2016 38 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by TCM Biotech International Corp, H1 2016 39 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Tobira Therapeutics, Inc., H1 2016 40 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Verva Pharmaceuticals Limited, H1 2016 41 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Zafgen Inc., H1 2016 42 Non Alcoholic Fatty Liver Disease (NAFLD) - Pipeline by Zydus Cadila Healthcare Limited, H1 2016 43 Assessment by Monotherapy Products, H1 2016 44 Assessment by Combination Products, H1 2016 45 Number of Products by Stage and Target, H1 2016 47 Number of Products by Stage and Mechanism of Action, H1 2016 50 Number of Products by Stage and Route of Administration, H1 2016 52 Number of Products by Stage and Molecule Type, H1 2016 53 Non Alcoholic Fatty Liver Disease (NAFLD) Therapeutics - Recent Pipeline Updates, H1 2016 102 Non Alcoholic Fatty Liver Disease (NAFLD) - Dormant Projects, H1 2016 122 Non Alcoholic Fatty Liver Disease (NAFLD) - Discontinued Products, H1 2016 123
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