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Published: Oct, 2014 | Pages:
150 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Neuroendocrine Tumors - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Neuroendocrine Tumors - Pipeline Review, H2 2014', provides an overview of the Neuroendocrine Tumors's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Neuroendocrine Tumors, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Neuroendocrine Tumors and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Neuroendocrine Tumors - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Neuroendocrine Tumors and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Neuroendocrine Tumors products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Neuroendocrine Tumors pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Neuroendocrine Tumors - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Neuroendocrine Tumors pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Neuroendocrine Tumors Overview 9 Therapeutics Development 10 Pipeline Products for Neuroendocrine Tumors - Overview 10 Pipeline Products for Neuroendocrine Tumors - Comparative Analysis 11 Neuroendocrine Tumors - Therapeutics under Development by Companies 12 Neuroendocrine Tumors - Therapeutics under Investigation by Universities/Institutes 14 Neuroendocrine Tumors - Pipeline Products Glance 15 Late Stage Products 15 Clinical Stage Products 16 Early Stage Products 17 Neuroendocrine Tumors - Products under Development by Companies 18 Neuroendocrine Tumors - Products under Investigation by Universities/Institutes 19 Neuroendocrine Tumors - Companies Involved in Therapeutics Development 20 Amgen Inc. 20 Chiasma, Inc. 21 Delcath Systems, Inc. 22 DexTech Medical AB 23 Hutchison MediPharma Limited 24 Intezyne, Inc 25 Ipsen S.A. 26 Karyopharm Therapeutics, Inc. 27 Merck & Co., Inc. 28 Nobelpharma Co., Ltd. 29 Novartis AG 30 OctreoPharm Sciences GmbH 31 OXiGENE, Inc. 32 Progenics Pharmaceuticals, Inc. 33 Sompharmaceuticals S.A. 34 Tekmira Pharmaceuticals Corp. 35 Threshold Pharmaceuticals, Inc. 36 Neuroendocrine Tumors - Therapeutics Assessment 37 Assessment by Monotherapy Products 37 Assessment by Target 38 Assessment by Mechanism of Action 40 Assessment by Route of Administration 42 Assessment by Molecule Type 44 Drug Profiles 46 DG-3173 - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 Edotreotide Labeled Yttrium 90 - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 everolimus - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 evofosfamide - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 fosbretabulin tromethamine - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 G-02113 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 ganitumab - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 HMPL-012 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 IT-139 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 lanreotide acetate - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 melphalan - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 MK-2206 - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 octreotide acetate - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 OPS-201 - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 panobinostat - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 pasireotide LAR - Drug Profile 90 Product Description 90 Mechanism of Action 90 R&D Progress 90 Peptides for Oncology - Drug Profile 92 Product Description 92 Mechanism of Action 92 R&D Progress 92 selinexor - Drug Profile 93 Product Description 93 Mechanism of Action 93 R&D Progress 93 Small Molecules to Activate Somatostatin Receptor Type 4 for Oncology, Genito Urinary System And Sex Hormones and Metabolic Disorders - Drug Profile 96 Product Description 96 Mechanism of Action 96 R&D Progress 96 SNX-5422 - Drug Profile 97 Product Description 97 Mechanism of Action 97 R&D Progress 97 Somadex - Drug Profile 99 Product Description 99 Mechanism of Action 99 R&D Progress 99 streptozocin - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 Synthetic Peptide to Antagonize Somatostatin Receptor Type 2 for Neuroendocrine Tumors - Drug Profile 101 Product Description 101 Mechanism of Action 101 R&D Progress 101 TKM-PLK1 - Drug Profile 102 Product Description 102 Mechanism of Action 102 R&D Progress 102 Neuroendocrine Tumors - Recent Pipeline Updates 104 Neuroendocrine Tumors - Dormant Projects 138 Neuroendocrine Tumors - Discontinued Products 139 Neuroendocrine Tumors - Product Development Milestones 140 Featured News & Press Releases 140 Sep 17, 2014: Novartis presents oncology research advances with new data on Afinitor at ESMO 2014 140 Sep 17, 2014: OXiGENE Initiates Phase 2 Study of Fosbretabulin in Gastrointestinal Neuroendocrine Tumors 140 Sep 01, 2014: Ipsen Announces Acceptance of Filings for Somatuline in the Treatment of GEP-NET1s in the US with Priority Review and in Europe 141 Jul 16, 2014: New England Journal of Medicine Publishes Ipsen's Somatuline CLARINET Phase III Results in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors 142 Jul 01, 2014: Ipsen submits marketing authorization applications in the US and Europe for Somatuline (lanreotide) in the treatment of gastroenteropancreatic neuroendocrine tumors 143 Jan 17, 2014: Ipsen announces at ASCO GI that ELECT clinical trial of Somatuline in the control of symptoms in GEP-NET1 patients with carcinoid syndrome met its primary endpoint 144 Jan 14, 2014: Ipsen to set up its own US oncology team for Somatuline Depot Injection in neuroendocrine tumors 145 Oct 21, 2013: OXiGENE Presents Preclinical Data Demonstrating Significant Antitumor Activity of ZYBRESTAT in Pancreatic Neuroendocrine Tumor Model 146 Oct 15, 2013: Sompharmaceuticals receives CHF 100,000 award from the Swiss Foundation for Technological Innovation 147 Oct 08, 2013: Tekmira Provides Corporate Update On Oncology Product Candidate TKM-PLK1 147 Appendix 149 Methodology 149 Coverage 149 Secondary Research 149 Primary Research 149 Expert Panel Validation 149 Contact Us 150 Disclaimer 150
List of Tables Number of Products under Development for Neuroendocrine Tumors, H2 2014 10 Number of Products under Development for Neuroendocrine Tumors - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Investigation by Universities/Institutes, H2 2014 14 Comparative Analysis by Late Stage Development, H2 2014 15 Comparative Analysis by Clinical Stage Development, H2 2014 16 Comparative Analysis by Early Stage Development, H2 2014 17 Products under Development by Companies, H2 2014 18 Products under Investigation by Universities/Institutes, H2 2014 19 Neuroendocrine Tumors - Pipeline by Amgen Inc., H2 2014 20 Neuroendocrine Tumors - Pipeline by Chiasma, Inc., H2 2014 21 Neuroendocrine Tumors - Pipeline by Delcath Systems, Inc., H2 2014 22 Neuroendocrine Tumors - Pipeline by DexTech Medical AB, H2 2014 23 Neuroendocrine Tumors - Pipeline by Hutchison MediPharma Limited, H2 2014 24 Neuroendocrine Tumors - Pipeline by Intezyne, Inc, H2 2014 25 Neuroendocrine Tumors - Pipeline by Ipsen S.A., H2 2014 26 Neuroendocrine Tumors - Pipeline by Karyopharm Therapeutics, Inc., H2 2014 27 Neuroendocrine Tumors - Pipeline by Merck & Co., Inc., H2 2014 28 Neuroendocrine Tumors - Pipeline by Nobelpharma Co., Ltd., H2 2014 29 Neuroendocrine Tumors - Pipeline by Novartis AG, H2 2014 30 Neuroendocrine Tumors - Pipeline by OctreoPharm Sciences GmbH, H2 2014 31 Neuroendocrine Tumors - Pipeline by OXiGENE, Inc., H2 2014 32 Neuroendocrine Tumors - Pipeline by Progenics Pharmaceuticals, Inc., H2 2014 33 Neuroendocrine Tumors - Pipeline by Sompharmaceuticals S.A., H2 2014 34 Neuroendocrine Tumors - Pipeline by Tekmira Pharmaceuticals Corp., H2 2014 35 Neuroendocrine Tumors - Pipeline by Threshold Pharmaceuticals, Inc., H2 2014 36 Assessment by Monotherapy Products, H2 2014 37 Number of Products by Stage and Target, H2 2014 39 Number of Products by Stage and Mechanism of Action, H2 2014 41 Number of Products by Stage and Route of Administration, H2 2014 43 Number of Products by Stage and Molecule Type, H2 2014 45 Neuroendocrine Tumors Therapeutics - Recent Pipeline Updates, H2 2014 104 Neuroendocrine Tumors - Dormant Projects, H2 2014 138 Neuroendocrine Tumors - Discontinued Products, H2 2014 139
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