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Published: Oct, 2016 | Pages:
88 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Pipeline Review, H2 2016 Summary Global Markets Direct's, 'Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Pipeline Review, H2 2016', provides in depth analysis on Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted pipeline therapeutics. The report provides comprehensive information on the Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics development and features dormant and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Note: *Certain sections in the report may be removed or altered based on the availability and relevance of data. *Updated report will be delivered in 48 hours of order confirmation. Scope - The report provides a snapshot of the global therapeutic landscape for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - The report reviews Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics and enlists all their major and minor projects - The report assesses Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type - The report summarizes all the dormant and discontinued pipeline projects - The report reviews latest news and deals related to Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics Reasons To Buy - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Identify and understand the targeted therapy areas and indications for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Identify the use of drugs for target identification and drug repurposing - Identify potential new clients or partners in the target demographic - Develop strategic initiatives by understanding the focus areas of leading companies - Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics - Devise corrective measures for pipeline projects by understanding Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) development landscape - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) Overview 9 Therapeutics Development 10 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Products under Development by Stage of Development 10 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Products under Development by Therapy Area 11 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Products under Development by Indication 12 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Pipeline Products Glance 14 Late Stage Products 14 Early Stage Products 15 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Products under Development by Companies 16 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Products under Development by Universities/Institutes 19 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Therapeutics Assessment 21 Assessment by Monotherapy/Combination Products 21 Assessment by Mechanism of Action 22 Assessment by Route of Administration 24 Assessment by Molecule Type 25 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Companies Involved in Therapeutics Development 26 Addex Therapeutics Ltd 26 Bristol-Myers Squibb Company 27 Eisai Co., Ltd. 28 Eli Lilly and Company 29 Heptares Therapeutics Limited 30 Hua Medicine (Shanghai) Ltd. 31 Johnson & Johnson 32 Medgenics, Inc. 33 Merz Pharma GmbH & Co. KgaA 34 Sumitomo Dainippon Pharma Co., Ltd. 35 Toray Industries, Inc. 36 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Drug Profiles 37 alloswitch-1 - Drug Profile 37 Product Description 37 Mechanism Of Action 37 R&D Progress 37 BMS-952048 - Drug Profile 38 Product Description 38 Mechanism Of Action 38 R&D Progress 38 BMS-955829 - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 dipraglurant ER - Drug Profile 40 Product Description 40 Mechanism Of Action 40 R&D Progress 40 dipraglurant IR - Drug Profile 41 Product Description 41 Mechanism Of Action 41 R&D Progress 41 Drug to Antagonize mGluR5 for Fragile X Syndrome and 16p11.2 Microdeletion Syndrome - Drug Profile 46 Product Description 46 Mechanism Of Action 46 R&D Progress 46 DSR-98776 - Drug Profile 47 Product Description 47 Mechanism Of Action 47 R&D Progress 47 fasoracetam - Drug Profile 48 Product Description 48 Mechanism Of Action 48 R&D Progress 48 GET-73 - Drug Profile 50 Product Description 50 Mechanism Of Action 50 R&D Progress 50 HTL-14242 - Drug Profile 51 Product Description 51 Mechanism Of Action 51 R&D Progress 51 JNJ-46778212 - Drug Profile 52 Product Description 52 Mechanism Of Action 52 R&D Progress 52 LSN-2463359 - Drug Profile 53 Product Description 53 Mechanism Of Action 53 R&D Progress 53 LSN-2814617 - Drug Profile 54 Product Description 54 Mechanism Of Action 54 R&D Progress 54 remeglurant - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 Small Molecule to Agonize Metabotropic Glutamate Receptor 5 for Cognitive Disorders - Drug Profile 56 Product Description 56 Mechanism Of Action 56 R&D Progress 56 Small Molecule to Antagonize mGlu5 for Pain - Drug Profile 57 Product Description 57 Mechanism Of Action 57 R&D Progress 57 Small Molecule to Antagonize mGluR5 for CNS Disorders - Drug Profile 58 Product Description 58 Mechanism Of Action 58 R&D Progress 58 Small Molecules to Agonize mGluR5 for Schizophrenia - Drug Profile 59 Product Description 59 Mechanism Of Action 59 R&D Progress 59 Small Molecules to Antagonize mGluR5 for Anxiety - Drug Profile 60 Product Description 60 Mechanism Of Action 60 R&D Progress 60 Small Molecules to Antagonize mGLUR5 for Central Nervous System Disorders - Drug Profile 61 Product Description 61 Mechanism Of Action 61 R&D Progress 61 Small Molecules to Antagonize mGluR5 for Dyskinesia - Drug Profile 62 Product Description 62 Mechanism Of Action 62 R&D Progress 62 VU-0092273 - Drug Profile 63 Product Description 63 Mechanism Of Action 63 R&D Progress 63 VU-0431316 - Drug Profile 64 Product Description 64 Mechanism Of Action 64 R&D Progress 64 VU-0463841 - Drug Profile 65 Product Description 65 Mechanism Of Action 65 R&D Progress 65 VU-0467558 - Drug Profile 66 Product Description 66 Mechanism Of Action 66 R&D Progress 66 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Dormant Projects 67 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Discontinued Products 71 Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) - Featured News & Press Releases 73 Jun 17, 2016: Medgenics Announces Enrollment of First Patient in Phase 2/3 Clinical Trial of NFC-1 in Adolescents With mGluR Mutation Positive ADHD 73 Jun 02, 2016: Addex Dipraglurant Positive Phase 2 Data in PD-LID Published in Leading Peer Reviewed Journal of the Movement Disorder Society 73 Apr 11, 2016: Addex Reports Positive Results of an mGlu5 Receptor Occupancy Study with Dipraglurant in Healthy Volunteers 74 Mar 15, 2016: Addex Reports Successful Completion of an mGlu5 Receptor Occupancy Study with Dipraglurant in Healthy Volunteers 76 Jan 11, 2016: Addex Dipraglurant Shows Highly Statistically Significant Anti-Dyskinetic Effects Following Additional Analysis of Data from the PD-LID Phase II Proof of Concept 77 Jan 04, 2016: Addex' Dipraglurant Receives Orphan Drug Designation from the FDA for Levodopa-Induced Dyskinesia Associated with Parkinson's Disease 78 Dec 17, 2015: Addex Reports Statistically Significant Positive Interim Data for Dipraglurant in Healthy Volunteer mGlu5 Receptor Occupancy Trial 78 Aug 14, 2015: Addex Dipraglurant Demonstrates Anxiolytic- and Antidepressant-like Activity in Multiple Preclinical Models Relevant for Non-Motor Symptoms in Parkinson's Disease 79 Jul 22, 2015: Addex Dipraglurant Dosed in First Subject in Receptor Occupancy Study in Collaboration with Johns Hopkins University and with Funding from The Michael J. Fox Foundation 80 Feb 23, 2015: Addex Initiates Dipraglurant Receptor Occupancy Clinical Study in Collaboration with Johns Hopkins University with Funding from The Michael J. Fox Foundation 81 Jan 19, 2015: Addex and Dystonia Medical Research Foundation Announce Partnership to Explore the Therapeutic use of Dipraglurant in the Treatment of Dystonia 82 Sep 04, 2013: Chronic treatment with Addex Dipraglurant Rescues Impairment of Long-Term Synaptic Plasticity in a Validated Preclinical Model of Primary Generalized Torsion Dystonia 1 82 May 01, 2013: Addex's Dipragluant Demonstrates Dose-dependent mGlu5 Receptor Occupancy In Non-human Primate PET Study 83 Apr 22, 2013: Addex Obtains European Composition Of Matter Patent Covering Dipraglurant And Other mGlu5 Negative Allosteric Modulators 85 Apr 18, 2013: Addex's Dipraglurant Normalizes Striatal Cholinergic Dysfunction In Validated Preclinical Model Of Primary Generalized Torsion Dystonia 1 85 Appendix 87 Methodology 87 Coverage 87 Secondary Research 87 Primary Research 87 Expert Panel Validation 87 Contact Us 87 Disclaimer 88
List of Tables Number of Products under Development for, H2 2016 10 Number of Products under Development by Therapy Area, H2 2016 11 Number of Products under Development by Indication, H2 2016 13 Comparative Analysis by Late Stage Development, H2 2016 14 Comparative Analysis by Early Stage Products, H2 2016 15 Number of Products under Development by Companies, H2 2016 16 Products under Development by Companies, H2 2016 17 Products under Development by Companies, H2 2016 (Contd..1) 18 Number of Products under Investigation by Universities/Institutes, H2 2016 19 Products under Investigation by Universities/Institutes, H2 2016 20 Assessment by Monotherapy/Combination Products, H2 2016 21 Number of Products by Stage and Mechanism of Action, H2 2016 23 Number of Products by Stage and Route of Administration, H2 2016 24 Number of Products by Stage and Molecule Type, H2 2016 25 Pipeline by Addex Therapeutics Ltd, H2 2016 26 Pipeline by Bristol-Myers Squibb Company, H2 2016 27 Pipeline by Eisai Co., Ltd., H2 2016 28 Pipeline by Eli Lilly and Company, H2 2016 29 Pipeline by Heptares Therapeutics Limited, H2 2016 30 Pipeline by Hua Medicine (Shanghai) Ltd., H2 2016 31 Pipeline by Johnson & Johnson, H2 2016 32 Pipeline by Medgenics, Inc., H2 2016 33 Pipeline by Merz Pharma GmbH & Co. KgaA, H2 2016 34 Pipeline by Sumitomo Dainippon Pharma Co., Ltd., H2 2016 35 Pipeline by Toray Industries, Inc., H2 2016 36 Dormant Projects, H2 2016 67 Dormant Projects (Contd..1), H2 2016 68 Dormant Projects (Contd..2), H2 2016 69 Dormant Projects (Contd..3), H2 2016 70 Discontinued Products, H2 2016 71 Discontinued Products (Contd..1), H2 2016 72
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