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Published: Jul, 2014 | Pages:
70 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Liver Failure - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Liver Failure - Pipeline Review, H2 2014', provides an overview of the Liver Failure's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Liver Failure, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Liver Failure and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Liver Failure - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Liver Failure and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Liver Failure products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Liver Failure pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Liver Failure - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Liver Failure pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Liver Failure Overview 7 Therapeutics Development 8 Pipeline Products for Liver Failure - Overview 8 Pipeline Products for Liver Failure - Comparative Analysis 9 Liver Failure - Therapeutics under Development by Companies 10 Liver Failure - Therapeutics under Investigation by Universities/Institutes 11 Liver Failure - Pipeline Products Glance 12 Clinical Stage Products 12 Early Stage Products 13 Unknown Stage Products 14 Liver Failure - Products under Development by Companies 15 Liver Failure - Products under Investigation by Universities/Institutes 16 Liver Failure - Companies Involved in Therapeutics Development 17 Grifols, S.A. 17 Digna Biotech, S.L. 18 Ventria Bioscience 19 Conatus Pharmaceuticals Inc. 20 Pharmicell Co., Ltd. 21 Alfact Innovation 22 Immune Pharmaceuticals, Inc. 23 Liver Failure - Therapeutics Assessment 24 Assessment by Monotherapy Products 24 Assessment by Target 25 Assessment by Mechanism of Action 28 Assessment by Route of Administration 31 Assessment by Molecule Type 33 Drug Profiles 35 emricasan - Drug Profile 35 Product Description 35 Mechanism of Action 35 R&D Progress 35 ALF-5755 - Drug Profile 38 Product Description 38 Mechanism of Action 38 R&D Progress 38 Livercellgram - Drug Profile 39 Product Description 39 Mechanism of Action 39 R&D Progress 39 Stem Cell Therapy for Immunology and Gastrointestinal Disorders - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 cardiotrophin-1 - Drug Profile 42 Product Description 42 Mechanism of Action 42 R&D Progress 42 EP-1013 - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 talactoferrin alfa - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 Stem Cell Therapy for Liver Failure - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 TAT-ARC - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 Chimeric Fusion Protein - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 RNAi Oligonucleotides to Inhibit MAP Kinase for Liver Failure - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 MicroRNA-221 - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 Small Molecules to Activate Glutathione Peroxidase for Ischemic Stroke and Liver Failure - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 ImmuneSafe - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 albumin (human) - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 Liver Failure - Recent Pipeline Updates 57 Liver Failure - Dormant Projects 62 Liver Failure - Product Development Milestones 63 Featured News & Press Releases 63 Nov 27, 2013: NICE seeks more information on treatment for potentially serious liver condition 63 Nov 02, 2013: Conatus Pharmaceuticals Presents Data Demonstrating Emricasan's Safety Profile at the AASLD Liver Meeting 63 Apr 02, 2013: ALF-5755 phase II completion 64 Nov 08, 2012: Ocera Therapeutics Enrolls First Patient In Phase IIa Study Of OCR-002 In Treatment Of Patients With Acute Liver Injury 64 Aug 03, 2012: MDC Researchers Develop New Approach to Treat Acute Liver Failure 65 Sep 21, 2011: Digna Biotech Receives FDA Orphan Drug Status For Cardiotrophin-1 For Acute Liver Failure Treatment 66 May 06, 2011: ALF-5755 phase II extends to germany 67 May 05, 2011: Alfact Innovation Receives Orphan Drug Designation For ALF-5755 From FDA 67 Mar 16, 2011: Digna Biotech And Biotecnol Receive Spanish Approval For Phase I Clinical Studies Of Cardiotrophin I 67 Mar 10, 2011: Digna Biotech And Biotecnol Announce Spanish Approval For Phase I Clinical study Of Cardiotrophin I 68 Appendix 69 Methodology 69 Coverage 69 Secondary Research 69 Primary Research 69 Expert Panel Validation 69 Contact Us 70 Disclaimer 70
List of Tables Number of Products under Development for Liver Failure, H2 2014 8 Number of Products under Development for Liver Failure - Comparative Analysis, H2 2014 9 Number of Products under Development by Companies, H2 2014 10 Number of Products under Investigation by Universities/Institutes, H2 2014 11 Comparative Analysis by Clinical Stage Development, H2 2014 12 Comparative Analysis by Early Stage Development, H2 2014 13 Comparative Analysis by Unknown Stage Development, H2 2014 14 Products under Development by Companies, H2 2014 15 Products under Investigation by Universities/Institutes, H2 2014 16 Liver Failure - Pipeline by Grifols, S.A., H2 2014 17 Liver Failure - Pipeline by Digna Biotech, S.L., H2 2014 18 Liver Failure - Pipeline by Ventria Bioscience, H2 2014 19 Liver Failure - Pipeline by Conatus Pharmaceuticals Inc., H2 2014 20 Liver Failure - Pipeline by Pharmicell Co., Ltd., H2 2014 21 Liver Failure - Pipeline by Alfact Innovation, H2 2014 22 Liver Failure - Pipeline by Immune Pharmaceuticals, Inc., H2 2014 23 Assessment by Monotherapy Products, H2 2014 24 Number of Products by Stage and Target, H2 2014 27 Number of Products by Stage and Mechanism of Action, H2 2014 30 Number of Products by Stage and Route of Administration, H2 2014 32 Number of Products by Stage and Molecule Type, H2 2014 34 Liver Failure Therapeutics - Recent Pipeline Updates, H2 2014 57 Liver Failure - Dormant Projects, H2 2014 62
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