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Published: Oct, 2016 | Pages:
123 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Pipeline Review, H2 2016 Summary Global Markets Direct's, 'Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Pipeline Review, H2 2016', provides in depth analysis on Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted pipeline therapeutics. The report provides comprehensive information on the Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics development and features dormant and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Note: *Certain sections in the report may be removed or altered based on the availability and relevance of data. *Updated report will be delivered in 48 hours of order confirmation. Scope - The report provides a snapshot of the global therapeutic landscape for Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - The report reviews Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics and enlists all their major and minor projects - The report assesses Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type - The report summarizes all the dormant and discontinued pipeline projects - The report reviews latest news and deals related to Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics Reasons To Buy - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Identify and understand the targeted therapy areas and indications for Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Identify the use of drugs for target identification and drug repurposing - Identify potential new clients or partners in the target demographic - Develop strategic initiatives by understanding the focus areas of leading companies - Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics - Devise corrective measures for pipeline projects by understanding Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) development landscape - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) Overview 10 Therapeutics Development 11 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Products under Development by Stage of Development 11 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Products under Development by Therapy Area 12 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Products under Development by Indication 13 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Pipeline Products Glance 16 Late Stage Products 16 Early Stage Products 17 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Products under Development by Companies 18 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Products under Development by Universities/Institutes 24 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Therapeutics Assessment 26 Assessment by Monotherapy/Combination Products 26 Assessment by Mechanism of Action 27 Assessment by Route of Administration 28 Assessment by Molecule Type 30 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Companies Involved in Therapeutics Development 32 Acetylon Pharmaceuticals, Inc. 32 Chong Kun Dang Pharmaceutical Corp. 34 Curis, Inc. 35 HitGen LTD 36 Kancera AB 37 Karus Therapeutics Limited 38 Lycera Corp. 39 Merck & Co., Inc. 40 Millennium Pharmaceuticals Inc 41 OncoHoldings, Inc. 42 OnKure Inc 43 Quimatryx, S.L. 44 Sigma-Tau S.p.A. 45 SK Biopharmaceuticals Co., Ltd. 46 Takeda Pharmaceutical Company Limited 47 TetraLogic Pharmaceuticals 48 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Drug Profiles 49 ACY-738 - Drug Profile 49 Product Description 49 Mechanism Of Action 49 R&D Progress 49 ACY-775 - Drug Profile 50 Product Description 50 Mechanism Of Action 50 R&D Progress 50 C-1A - Drug Profile 51 Product Description 51 Mechanism Of Action 51 R&D Progress 51 citarinostat - Drug Profile 52 Product Description 52 Mechanism Of Action 52 R&D Progress 52 CKD-504 - Drug Profile 54 Product Description 54 Mechanism Of Action 54 R&D Progress 54 CKD-506 - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 CKD-L - Drug Profile 56 Product Description 56 Mechanism Of Action 56 R&D Progress 56 CUDC-907 - Drug Profile 57 Product Description 57 Mechanism Of Action 57 R&D Progress 57 HG-3001 - Drug Profile 62 Product Description 62 Mechanism Of Action 62 R&D Progress 62 IKH-12 - Drug Profile 63 Product Description 63 Mechanism Of Action 63 R&D Progress 63 KA-2507 - Drug Profile 64 Product Description 64 Mechanism Of Action 64 R&D Progress 64 KAN-0439221 - Drug Profile 65 Product Description 65 Mechanism Of Action 65 R&D Progress 65 KAN-0439782 - Drug Profile 66 Product Description 66 Mechanism Of Action 66 R&D Progress 66 KAR-3000 - Drug Profile 67 Product Description 67 Mechanism Of Action 67 R&D Progress 67 MPT-0B291 - Drug Profile 68 Product Description 68 Mechanism Of Action 68 R&D Progress 68 N-140 - Drug Profile 69 Product Description 69 Mechanism Of Action 69 R&D Progress 69 Nexturastat A - Drug Profile 70 Product Description 70 Mechanism Of Action 70 R&D Progress 70 ONCO-101 - Drug Profile 71 Product Description 71 Mechanism Of Action 71 R&D Progress 71 QTX-100 Series - Drug Profile 72 Product Description 72 Mechanism Of Action 72 R&D Progress 72 QTX-102 - Drug Profile 73 Product Description 73 Mechanism Of Action 73 R&D Progress 73 QTX-125 - Drug Profile 74 Product Description 74 Mechanism Of Action 74 R&D Progress 74 QTX-153 - Drug Profile 75 Product Description 75 Mechanism Of Action 75 R&D Progress 75 remetinostat - Drug Profile 76 Product Description 76 Mechanism Of Action 76 R&D Progress 76 ricolinostat - Drug Profile 78 Product Description 78 Mechanism Of Action 78 R&D Progress 78 Small Molecule to HDAC6 HDAC6 for Sepsis - Drug Profile 86 Product Description 86 Mechanism Of Action 86 R&D Progress 86 Small Molecule to Inhibit HDAC1, HDAC3 and HDAC6 for Lung Adenocarcinoma - Drug Profile 87 Product Description 87 Mechanism Of Action 87 R&D Progress 87 Small Molecule to Inhibit HDAC6 - Drug Profile 88 Product Description 88 Mechanism Of Action 88 R&D Progress 88 Small Molecule to Inhibit HDAC6 for Charcot-Marie-Tooth Disease - Drug Profile 89 Product Description 89 Mechanism Of Action 89 R&D Progress 89 Small Molecule to Inhibit HDAC6 for Oncology - Drug Profile 90 Product Description 90 Mechanism Of Action 90 R&D Progress 90 Small Molecules to Inhibit HDAC-6 for Immunology, Oncology and Genetic Disorders - Drug Profile 91 Product Description 91 Mechanism Of Action 91 R&D Progress 91 Small Molecules to Inhibit HDAC6 for Autoimmune Diseases - Drug Profile 92 Product Description 92 Mechanism Of Action 92 R&D Progress 92 Small Molecules to Inhibit HDAC6 for Neurodegenerative, Autoimmune and Inflammatory Diseases - Drug Profile 93 Product Description 93 Mechanism Of Action 93 R&D Progress 93 Small Molecules to Inhibit HDAC6 for Oncology - Drug Profile 94 Product Description 94 Mechanism Of Action 94 R&D Progress 94 Small Molecules to Inhibit HDAC6 for Oncology and Immunology - Drug Profile 95 Product Description 95 Mechanism Of Action 95 R&D Progress 95 Small Molecules to Inhibit Histone Deacetylase 6 for Oncology - Drug Profile 96 Product Description 96 Mechanism Of Action 96 R&D Progress 96 ST-3595 - Drug Profile 97 Product Description 97 Mechanism Of Action 97 R&D Progress 97 Synthetic Peptides to Inhibit HDAC6 for Oncology - Drug Profile 98 Product Description 98 Mechanism Of Action 98 R&D Progress 98 vorinostat - Drug Profile 99 Product Description 99 Mechanism Of Action 99 R&D Progress 99 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Dormant Projects 103 Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) - Featured News & Press Releases 106 Jun 13, 2016: Acetylon Presents Data on the Use of HDAC6 Inhibitor Ricolinostat (ACY-1215) in Combination with Pomalidomide and Dexamethasone for the Treatment of Multiple Myeloma 106 Jun 13, 2016: Acetylon Presents Data on the Use of HDAC6 Inhibitor ACY-241 in Combination with Pomalidomide and Dexamethasone for the Treatment of Multiple Myeloma 107 Jun 08, 2016: Curis Announces Oral Presentation of Clinical Data Update from the Phase 1 Study of CUDC-907 at the 21st Congress of the European Hematology Association 107 Jun 03, 2016: Acetylon Collaborators Publish ASCO Abstracts Demonstrating Immunomodulatory Properties of Ricolinostat in Preclinical Melanoma Models 108 Jun 02, 2016: Curis Announces Presentations Related to CUDC-907 at 2016 ASCO Annual Meeting 109 Apr 20, 2016: Acetylon Announces the Presentation of Preclinical Data at AACR Supporting the Use of Selective HDAC6 Inhibition to Modulate Chronic Lymphocytic Leukemia (CLL) Immunobiology 109 Apr 11, 2016: Curis Announces Presentation of Preclinical Data for CUDC-907 at AACR Annual Meeting 111 Apr 04, 2016: Curis Announces Publication of CUDC-907 Phase 1 Clinical Trial Data in Lancet Oncology 111 Dec 07, 2015: Acetylon Presents Data from Three Phase 1b Studies of Ricolinostat (ACY-1215) for the Treatment of Lymphoma and Multiple Myeloma 111 Dec 07, 2015: Acetylon Presents Data on the use of HDAC 6 Inhibitors Ricolinostat and ACY-241 in Combination with Pomalidomide for the Treatment of Multiple Myeloma 113 Dec 06, 2015: Curis Reports Clinical Activity of CUDC-907 in Patients With DLBCL Harboring MYC Oncogene Alterations at the 2015 ASH Annual Meeting 115 Nov 06, 2015: Acetylon's Oral Selective HDAC6 Inhibitor ACY-241 Enhances Anti-tumor Activity of Paclitaxel in Preclinical Solid Tumor Models 117 Nov 05, 2015: Curis Announces Oral Presentation of Phase 1 Data for CUDC-907 at 2015 ASH Annual Meeting 118 Nov 02, 2015: TetraLogic Announces the Opening of an IND for SHAPE Gel in Alopecia Areata 119 Jun 15, 2015: Acetylon Pharmaceuticals Presented Positive Preliminary Data from Phase 1b/2 Trial of Ricolinostat in Combination with Pomalyst as Potential Oral Treatment for Patients with Multiple Myeloma 119 Appendix 122 Methodology 122 Coverage 122 Secondary Research 122 Primary Research 122 Expert Panel Validation 122 Contact Us 122 Disclaimer 123
List of Tables
Number of Products under Development for, H2 2016 11 Number of Products under Development by Therapy Area, H2 2016 12 Number of Products under Development by Indication, H2 2016 14 Comparative Analysis by Late Stage Development, H2 2016 16 Comparative Analysis by Early Stage Products, H2 2016 17 Number of Products under Development by Companies, H2 2016 18 Products under Development by Companies, H2 2016 19 Products under Development by Companies, H2 2016 (Contd..1) 20 Products under Development by Companies, H2 2016 (Contd..2) 21 Products under Development by Companies, H2 2016 (Contd..3) 22 Products under Development by Companies, H2 2016 (Contd..4) 23 Number of Products under Investigation by Universities/Institutes, H2 2016 24 Products under Investigation by Universities/Institutes, H2 2016 25 Assessment by Monotherapy/Combination Products, H2 2016 26 Number of Products by Stage and Mechanism of Action, H2 2016 27 Number of Products by Stage and Route of Administration, H2 2016 29 Number of Products by Stage and Molecule Type, H2 2016 31 Pipeline by Acetylon Pharmaceuticals, Inc., H2 2016 32 Pipeline by Chong Kun Dang Pharmaceutical Corp., H2 2016 34 Pipeline by Curis, Inc., H2 2016 35 Pipeline by HitGen LTD, H2 2016 36 Pipeline by Kancera AB, H2 2016 37 Pipeline by Karus Therapeutics Limited, H2 2016 38 Pipeline by Lycera Corp., H2 2016 39 Pipeline by Merck & Co., Inc., H2 2016 40 Pipeline by Millennium Pharmaceuticals Inc, H2 2016 41 Pipeline by OncoHoldings, Inc., H2 2016 42 Pipeline by OnKure Inc, H2 2016 43 Pipeline by Quimatryx, S.L., H2 2016 44 Pipeline by Sigma-Tau S.p.A., H2 2016 45 Pipeline by SK Biopharmaceuticals Co., Ltd., H2 2016 46 Pipeline by Takeda Pharmaceutical Company Limited, H2 2016 47 Pipeline by TetraLogic Pharmaceuticals, H2 2016 48 Dormant Projects, H2 2016 103 Dormant Projects (Contd..1), H2 2016 104 Dormant Projects (Contd..2), H2 2016 105
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