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Published: Oct, 2014 | Pages:
97 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
High Triglyceridemia - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'High Triglyceridemia - Pipeline Review, H2 2014', provides an overview of the High Triglyceridemia's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for High Triglyceridemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for High Triglyceridemia and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of High Triglyceridemia - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for High Triglyceridemia and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the High Triglyceridemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the High Triglyceridemia pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for High Triglyceridemia - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding High Triglyceridemia pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 High Triglyceridemia Overview 9 Therapeutics Development 10 Pipeline Products for High Triglyceridemia - Overview 10 Pipeline Products for High Triglyceridemia - Comparative Analysis 11 High Triglyceridemia - Therapeutics under Development by Companies 12 High Triglyceridemia - Therapeutics under Investigation by Universities/Institutes 14 High Triglyceridemia - Pipeline Products Glance 15 Late Stage Products 15 Clinical Stage Products 16 Early Stage Products 17 High Triglyceridemia - Products under Development by Companies 18 High Triglyceridemia - Products under Investigation by Universities/Institutes 19 High Triglyceridemia - Companies Involved in Therapeutics Development 20 Acasti Pharma Inc. 20 Actavis plc 21 Alnylam Pharmaceuticals, Inc. 22 Arisaph Pharmaceuticals, Inc. 23 Astellas Pharma Inc. 24 AstraZeneca PLC 25 Cardax Pharmaceuticals, Inc. 26 Catabasis Pharmaceuticals, Inc. 27 Essentialis, Inc. 28 Isis Pharmaceuticals, Inc. 29 Novartis AG 30 Pharmena SA 31 Poxel SA 32 Tekmira Pharmaceuticals Corp. 33 Thetis Pharmaceuticals LLC 34 Trygg Pharma AS 35 High Triglyceridemia - Therapeutics Assessment 36 Assessment by Monotherapy Products 36 Assessment by Target 37 Assessment by Mechanism of Action 39 Assessment by Route of Administration 41 Assessment by Molecule Type 43 Drug Profiles 45 AKR-963 - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 ALN-AC3 - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 ALN-ANG - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 ARI-3037MO - Drug Profile 48 Product Description 48 Mechanism of Action 48 R&D Progress 48 AS-1708727 - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 bezafibrate ER - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 CAT-2003 - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 CDX-085 - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 diazoxide choline CR - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 ISIS-APOCIIIRx - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 KBCV-001 - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 MAT-9001 - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 NKPL-66 - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 pradigastat sodium - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 RNAi Oligonucleotide for Hypertriglyceridemia - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 Small Molecule to Agonize Farnesoid X Receptor for Metabolic Disorders, Cardiovascular and Gastrointestinal Disorders - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 Small Molecules for Dyslipidemia and Hypertriglyceridemia - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 Synthetic Peptides for Dyslipidemic and Vascular Disorders - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 TP-101 - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 TP-110 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 TP-252 - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 TP-8252 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 TRIA-662 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 High Triglyceridemia - Recent Pipeline Updates 75 High Triglyceridemia - Dormant Projects 88 High Triglyceridemia - Discontinued Products 89 High Triglyceridemia - Product Development Milestones 90 Featured News & Press Releases 90 Oct 20, 2014: Matinas BioPharma Submits Investigational New Drug Application for Lead Product Candidate MAT9001 for the Treatment of Severe Hypertriglyceridemia 90 Sep 30, 2014: Matinas BioPharma to Present at the 13th Annual BIO Investor Forum on Wednesday, October 8, 2014 90 Sep 30, 2014: Acasti Announces Positive Top-Line Pharmacokinetic Results 91 Sep 29, 2014: Acasti Reports Successful CaPre Phase II TRIFECTA Results Proving Statistically Significant Improvements in Triglycerides & Non-HDL-C 91 Sep 04, 2014: Matinas BioPharma to Present at Three Investor Conferences in September 93 Sep 02, 2014: Isis Pharmaceuticals Presents Data On ISIS-APOCIIIRX At European Society of Cardiology Congress 2014 94 Jul 24, 2014: Acasti Announces Oral Presentation on COLT Study Results at 19th World Congress on Heart Disease in Boston 94 Jan 10, 2014: Matinas BioPharma Announces Presentation at Biotech Showcase 2014 in San Francisco on Tuesday, January 14, 2013 95 Dec 05, 2013: Catabasis Initiates Phase 2 Trial of CAT-2003 in Patients with Severe Hypertriglyceridemia 95 Nov 11, 2013: Acasti Completes PK IND Submission 95 Appendix 96 Methodology 96 Coverage 96 Secondary Research 96 Primary Research 96 Expert Panel Validation 96 Contact Us 97 Disclaimer 97
List of Tables Number of Products under Development for High Triglyceridemia, H2 2014 10 Number of Products under Development for High Triglyceridemia - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Investigation by Universities/Institutes, H2 2014 14 Comparative Analysis by Late Stage Development, H2 2014 15 Comparative Analysis by Clinical Stage Development, H2 2014 16 Comparative Analysis by Early Stage Development, H2 2014 17 Products under Development by Companies, H2 2014 18 Products under Investigation by Universities/Institutes, H2 2014 19 High Triglyceridemia - Pipeline by Acasti Pharma Inc., H2 2014 20 High Triglyceridemia - Pipeline by Actavis plc, H2 2014 21 High Triglyceridemia - Pipeline by Alnylam Pharmaceuticals, Inc., H2 2014 22 High Triglyceridemia - Pipeline by Arisaph Pharmaceuticals, Inc., H2 2014 23 High Triglyceridemia - Pipeline by Astellas Pharma Inc., H2 2014 24 High Triglyceridemia - Pipeline by AstraZeneca PLC, H2 2014 25 High Triglyceridemia - Pipeline by Cardax Pharmaceuticals, Inc., H2 2014 26 High Triglyceridemia - Pipeline by Catabasis Pharmaceuticals, Inc., H2 2014 27 High Triglyceridemia - Pipeline by Essentialis, Inc., H2 2014 28 High Triglyceridemia - Pipeline by Isis Pharmaceuticals, Inc., H2 2014 29 High Triglyceridemia - Pipeline by Novartis AG, H2 2014 30 High Triglyceridemia - Pipeline by Pharmena SA, H2 2014 31 High Triglyceridemia - Pipeline by Poxel SA, H2 2014 32 High Triglyceridemia - Pipeline by Tekmira Pharmaceuticals Corp., H2 2014 33 High Triglyceridemia - Pipeline by Thetis Pharmaceuticals LLC, H2 2014 34 High Triglyceridemia - Pipeline by Trygg Pharma AS, H2 2014 35 Assessment by Monotherapy Products, H2 2014 36 Number of Products by Stage and Target, H2 2014 38 Number of Products by Stage and Mechanism of Action, H2 2014 40 Number of Products by Stage and Route of Administration, H2 2014 42 Number of Products by Stage and Molecule Type, H2 2014 44 High Triglyceridemia Therapeutics - Recent Pipeline Updates, H2 2014 75 High Triglyceridemia - Dormant Projects, H2 2014 88 High Triglyceridemia - Discontinued Products, H2 2014 89
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