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Published: Jan, 2015 | Pages:
49 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Hepatic Encephalopathy - Pipeline Review, H1 2015 Summary Global Markets Direct's, 'Hepatic Encephalopathy - Pipeline Review, H1 2015', provides an overview of the Hepatic Encephalopathy's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Hepatic Encephalopathy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Hepatic Encephalopathy and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Hepatic Encephalopathy - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Hepatic Encephalopathy and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Hepatic Encephalopathy products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Hepatic Encephalopathy pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Hepatic Encephalopathy - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Hepatic Encephalopathy pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 4 List of Figures 4 Introduction 5 Global Markets Direct Report Coverage 5 Hepatic Encephalopathy Overview 6 Therapeutics Development 7 Pipeline Products for Hepatic Encephalopathy - Overview 7 Pipeline Products for Hepatic Encephalopathy - Comparative Analysis 8 Hepatic Encephalopathy - Therapeutics under Development by Companies 9 Hepatic Encephalopathy - Pipeline Products Glance 10 Late Stage Products 10 Clinical Stage Products 11 Early Stage Products 12 Hepatic Encephalopathy - Products under Development by Companies 13 Hepatic Encephalopathy - Companies Involved in Therapeutics Development 14 Alfa Wassermann S.p.A 14 Hyperion Therapeutics, Inc. 15 Ocera Therapeutics, Inc. 16 Umecrine Cognition AB 17 Hepatic Encephalopathy - Therapeutics Assessment 18 Assessment by Monotherapy Products 18 Assessment by Target 19 Assessment by Mechanism of Action 21 Assessment by Route of Administration 23 Assessment by Molecule Type 25 Drug Profiles 26 CVXL-0060 - Drug Profile 26 Product Description 26 Mechanism of Action 26 R&D Progress 26 glycerol phenylbutyrate - Drug Profile 27 Product Description 27 Mechanism of Action 27 R&D Progress 27 ornithine phenylacetate - Drug Profile 30 Product Description 30 Mechanism of Action 30 R&D Progress 30 rifaximin - Drug Profile 32 Product Description 32 Mechanism of Action 32 R&D Progress 32 THDP-17 - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 Hepatic Encephalopathy - Recent Pipeline Updates 35 Hepatic Encephalopathy - Dormant Projects 41 Hepatic Encephalopathy - Product Development Milestones 42 Featured News & Press Releases 42 Sep 18, 2014: Salix Secures Additional Intellectual Property Relating to Rifaximin 42 Sep 12, 2014: Lupin and Salix Announce Exclusive Distribution Agreement for Zaxine in Canada 42 Feb 25, 2014: Hyperion Therapeutics Announces the Publication of Phase 2 Results of Glycerol Phenylbutyrate for the Treatment of Hepatic Encephalopathy in Hepatology 43 Feb 14, 2014: Luxembourg National Health Fund Approves Reimbursement Of Xifaxan 550 43 Feb 04, 2014: Salix Pharmaceuticals Announces Issuance Of U. S. Patent For Rifaximin 44 Jan 08, 2014: Ocera Therapeutics Announces Enrollment of the First Patient in a Phase IIb Study for Treatment of Acute Hepatic Encephalopathy 44 Nov 01, 2013: Salix Pharmaceuticals Outlines Data Presentations at American Association for the Study of Liver Diseases Annual Meeting 45 Sep 09, 2013: Scottish Medicines Consortium Accepts TARGAXAN 550 46 May 24, 2013: Norgine Announces PBAC Approval For Xifaxan 550mg In Prevention Of Recurrence Of Hepatic Encephalopathy 46 May 17, 2013: Salix Pharma To Present Data On Rifaximin At Digestive Disease Week 2013 47 Appendix 48 Methodology 48 Coverage 48 Secondary Research 48 Primary Research 48 Expert Panel Validation 48 Contact Us 48 Disclaimer 49
List of Tables Number of Products under Development for Hepatic Encephalopathy, H1 2015 7 Number of Products under Development for Hepatic Encephalopathy - Comparative Analysis, H1 2015 8 Number of Products under Development by Companies, H1 2015 9 Comparative Analysis by Late Stage Development, H1 2015 10 Comparative Analysis by Clinical Stage Development, H1 2015 11 Comparative Analysis by Early Stage Development, H1 2015 12 Products under Development by Companies, H1 2015 13 Hepatic Encephalopathy - Pipeline by Alfa Wassermann S.p.A, H1 2015 14 Hepatic Encephalopathy - Pipeline by Hyperion Therapeutics, Inc., H1 2015 15 Hepatic Encephalopathy - Pipeline by Ocera Therapeutics, Inc., H1 2015 16 Hepatic Encephalopathy - Pipeline by Umecrine Cognition AB, H1 2015 17 Assessment by Monotherapy Products, H1 2015 18 Number of Products by Stage and Target, H1 2015 20 Number of Products by Stage and Mechanism of Action, H1 2015 22 Number of Products by Stage and Route of Administration, H1 2015 24 Number of Products by Stage and Molecule Type, H1 2015 25 Hepatic Encephalopathy Therapeutics - Recent Pipeline Updates, H1 2015 35 Hepatic Encephalopathy - Dormant Projects, H1 2015 41
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