Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Pipeline Review, H1 2016

Published: Jun, 2016 | Pages: 61 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Pipeline Review, H1 2016

Summary

Global Markets Direct's, 'Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Pipeline Review, H1 2016', provides in depth analysis on Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted pipeline therapeutics. 

The report provides comprehensive information on the Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted therapeutics development and features dormant and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26)
- The report reviews Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources 
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages 
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities 
- The report reviews key players involved in Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted therapeutics and enlists all their major and minor projects 
- The report assesses Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type 
- The report summarizes all the dormant and discontinued pipeline projects 
- The report reviews latest news and deals related to Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) targeted therapeutics

Reasons To Buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage 
- Identify and understand the targeted therapy areas and indications for Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies 
- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) development landscape 
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

 Table of Contents

Table of Contents 2
List of Tables 5
List of Figures 5
Introduction 6
Global Markets Direct Report Coverage 6
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) Overview 7
Therapeutics Development 8
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Products under Development by Stage of Development 8
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Products under Development by Therapy Area 9
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Products under Development by Indication 10
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Pipeline Products Glance 11
Late Stage Products 11
Early Stage Products 12
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Products under Development by Companies 13
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Products under Development by Universities/Institutes 15
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Therapeutics Assessment 17
Assessment by Monotherapy/Combination Products 17
Assessment by Mechanism of Action 18
Assessment by Route of Administration 19
Assessment by Molecule Type 21
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Companies Involved in Therapeutics Development 23
AMO Pharma Limited 23
Angelini Group 24
Celon Pharma Sp. z o.o. 25
DiaMedica Inc. 26
HitGen LTD 27
Jeil Pharmaceutical Co., Ltd. 28
Mitsubishi Tanabe Pharma Corporation 29
Neurim Pharmaceuticals Ltd 30
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Drug Profiles 31
CPL-202100 - Drug Profile 31
Product Description 31
Mechanism Of Action 31
R&D Progress 31
DM-199 - Drug Profile 32
Product Description 32
Mechanism Of Action 32
R&D Progress 32
DM-204 - Drug Profile 36
Product Description 36
Mechanism Of Action 36
R&D Progress 36
Drug to Inhibit GSK3-Beta for Alzheimer's Disease - Drug Profile 38
Product Description 38
Mechanism Of Action 38
R&D Progress 38
IB-AD - Drug Profile 39
Product Description 39
Mechanism Of Action 39
R&D Progress 39
JGK-263 - Drug Profile 40
Product Description 40
Mechanism Of Action 40
R&D Progress 40
manzamine A - Drug Profile 41
Product Description 41
Mechanism Of Action 41
R&D Progress 41
Neu-120 - Drug Profile 42
Product Description 42
Mechanism Of Action 42
R&D Progress 42
Small Molecule to Inhibit GSK-3 Beta for Menkes Disease and Tauopathies - Drug Profile 43
Product Description 43
Mechanism Of Action 43
R&D Progress 43
Small Molecule to Inhibit GSK3b for Type 2 Diabetes - Drug Profile 44
Product Description 44
Mechanism Of Action 44
R&D Progress 44
Small Molecules to Inhibit CDK1, CDK5 and GSK3b for Alzheimer's Disease - Drug Profile 45
Product Description 45
Mechanism Of Action 45
R&D Progress 45
Small Molecules to Inhibit GSK-3 Beta for CNS Disorders - Drug Profile 46
Product Description 46
Mechanism Of Action 46
R&D Progress 46
Small Molecules to Inhibit GSK-3 Beta for Neurodegenerative Diseases - Drug Profile 47
Product Description 47
Mechanism Of Action 47
R&D Progress 47
Small Molecules to Inhibit GSK3 Beta for Type 2 Diabetes, Oncology and Alzheimer's Disease - Drug Profile 48
Product Description 48
Mechanism Of Action 48
R&D Progress 48
tideglusib - Drug Profile 49
Product Description 49
Mechanism Of Action 49
R&D Progress 49
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Dormant Projects 50
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Discontinued Products 52
Glycogen Synthase Kinase 3 Beta (GSK-3 Beta or EC 2.7.11.26) - Featured News & Press Releases 53
Feb 02, 2016: DiaMedica Provides Update on DM199 Opportunity in South East Asia 53
Nov 04, 2015: DiaMedica Provides Corporate Update 53
Mar 19, 2015: DiaMedica to Present at the 12th Annual BIO Asia International Conference 54
Feb 02, 2015: DiaMedica to Expand Focus of DM199 Development into Acute Vascular Diseases 55
Nov 17, 2014: DiaMedica Announces Top-line Results of Phase IIa Clinical Trial of DM199 for Type 2 Diabetes 55
Aug 07, 2014: DiaMedica Publishes Manuscript Summarizing Preclinical Data on DM199 Treatment for Type 2 Diabetes 55
Jun 10, 2014: DiaMedica to Present Clinical Abstract on DM199 at the 74th Annual American Diabetes Association Conference 56
Feb 19, 2014: DiaMedica announces successful completion of Phase 1 program for DM199 56
Jan 09, 2014: DiaMedica Completes Phase 1 Clinical Trial and Initiates Phase 2 Clinical Trial of DM199 in Type 2 Diabetic Patients 56
Sep 30, 2013: DiaMedica Announces Successful Phase I/II Clinical Results in Type 2 Diabetic Patients 57
Aug 20, 2013: DiaMedica Announces Completion of Enrollment of Type 2 Diabetic Patients in the DM199 Single Ascending Dose Clinical Study 58
Jun 24, 2013: DiaMedica Advances DM-199 Phase I/II Clinical Program For Treatment Of Type 2 Diabetes 58
Jun 20, 2013: Sanford Project & DiaMedica To Present Preclinical Abstract on DM-199 For Treatment Of Type 1 Diabetes At 73rd Annual ADA Conference 58
May 01, 2013: DiaMedica Initiates Phase I/II Clinical Trial Of DM-199 For Treatment Of Type 2 Diabetes 59
Apr 08, 2013: DiaMedica Receives Phase I/II Clinical Trial Regulatory Approval For DM-199 As Potential Treatment For Diabetes 59
Appendix 60
Methodology 60
Coverage 60
Secondary Research 60
Primary Research 60
Expert Panel Validation 60
Contact Us 60
Disclaimer 61

List of Tables

Number of Products under Development for, H1 2016 8
Number of Products under Development by Therapy Area, H1 2016 9
Number of Products under Development by Indication, H1 2016 10
Comparative Analysis by Late Stage Development, H1 2016 11
Comparative Analysis by Early Stage Products, H1 2016 12
Number of Products under Development by Companies, H1 2016 13
Products under Development by Companies, H1 2016 14
Number of Products under Investigation by Universities/Institutes, H1 2016 15
Products under Investigation by Universities/Institutes, H1 2016 16
Assessment by Monotherapy/Combination Products, H1 2016 17
Number of Products by Stage and Mechanism of Action, H1 2016 18
Number of Products by Stage and Route of Administration, H1 2016 20
Number of Products by Stage and Molecule Type, H1 2016 22
Pipeline by AMO Pharma Limited, H1 2016 23
Pipeline by Angelini Group, H1 2016 24
Pipeline by Celon Pharma Sp. z o.o., H1 2016 25
Pipeline by DiaMedica Inc., H1 2016 26
Pipeline by HitGen LTD, H1 2016 27
Pipeline by Jeil Pharmaceutical Co., Ltd., H1 2016 28
Pipeline by Mitsubishi Tanabe Pharma Corporation, H1 2016 29
Pipeline by Neurim Pharmaceuticals Ltd, H1 2016 30
Dormant Projects, H1 2016 50
Dormant Projects (Contd..1), H1 2016 51
Discontinued Products, H1 2016 52