Global Opioid Induced Constipation Drugs Market Size, Status and Forecast 2025

Published: Feb, 2018 | Pages: 101 | Publisher: QYResearch
Industry: Healthcare | Report Format: Electronic (PDF)

This report studies the global Opioid Induced Constipation Drugs market, analyzes and researches the Opioid Induced Constipation Drugs development status and forecast in United States, EU, Japan, China, India and Southeast Asia. This report focuses on the top players in global market, like
    Ironwood Pharmaceuticals Inc
    Daiichi Sankyo Co Ltd
    Pfizer
    Progenics Pharmaceuticals Inc
    Shionogi & Co., Ltd
    Allergan Plc
    Nektar Therapeutics
    Purdue Pharma
    S.L.A. Pharma AG
    Mundipharma International Limited
    Ono Pharmaceutical Co., Ltd
    Takeda Pharmaceutical Company Limited
    Theravance Biopharma Inc
    Valeant Pharmaceuticals International
    Cosmo Pharmaceuticals SA
    Daewoong Pharmaceutical
    C.B. Fleet Company
    Sucampo Pharmaceuticals

Market segment by Regions/Countries, this report covers
    United States
    EU
    Japan
    China
    India
    Southeast Asia

Market segment by Type, the product can be split into
    Lubiprostone
    Methyl Naltrexone Bromide
    Naldemedine
    Alvimopan
    Other

Market segment by Application, Opioid Induced Constipation Drugs can be split into
    Hospital Pharmacies
    Retail Pharmacies
    Online Pharmacies

If you have any special requirements, please let us know and we will offer you the report as you want.

 Table of Contents

Global Opioid Induced Constipation Drugs Market Size, Status and Forecast 2025
1 Industry Overview of Opioid Induced Constipation Drugs
    1.1  Opioid Induced Constipation Drugs Market Overview
        1.1.1 Opioid Induced Constipation Drugs Product Scope
        1.1.2 Market Status and Outlook
    1.2 Global Opioid Induced Constipation Drugs Market Size and Analysis by Regions (2013-2018)
        1.2.1 United States
        1.2.2 EU
        1.2.3 Japan
        1.2.4 China
        1.2.5 India
        1.2.6 Southeast Asia
    1.3 Opioid Induced Constipation Drugs Market by Type
        1.3.1 Lubiprostone
        1.3.2 Methyl Naltrexone Bromide
        1.3.3 Naldemedine
        1.3.4 Alvimopan
        1.3.5 Other
    1.4 Opioid Induced Constipation Drugs Market by End Users/Application
        1.4.1 Hospital Pharmacies
        1.4.2 Retail Pharmacies
        1.4.3 Online Pharmacies

2 Global Opioid Induced Constipation Drugs Competition Analysis by Players
    2.1 Opioid Induced Constipation Drugs Market Size (Value) by Players (2013-2018)
    2.2 Competitive Status and Trend
        2.2.1 Market Concentration Rate
        2.2.2 Product/Service Differences
        2.2.3 New Entrants
        2.2.4 The Technology Trends in Future

3 Company (Top Players) Profiles
    3.1 Ironwood Pharmaceuticals Inc
        3.1.1 Company Profile
        3.1.2 Main Business/Business Overview
        3.1.3 Products, Services and Solutions
        3.1.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.1.5 Recent Developments
    3.2 Daiichi Sankyo Co Ltd
        3.2.1 Company Profile
        3.2.2 Main Business/Business Overview
        3.2.3 Products, Services and Solutions
        3.2.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.2.5 Recent Developments
    3.3 Pfizer
        3.3.1 Company Profile
        3.3.2 Main Business/Business Overview
        3.3.3 Products, Services and Solutions
        3.3.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.3.5 Recent Developments
    3.4 Progenics Pharmaceuticals Inc
        3.4.1 Company Profile
        3.4.2 Main Business/Business Overview
        3.4.3 Products, Services and Solutions
        3.4.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.4.5 Recent Developments
    3.5 Shionogi & Co., Ltd
        3.5.1 Company Profile
        3.5.2 Main Business/Business Overview
        3.5.3 Products, Services and Solutions
        3.5.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.5.5 Recent Developments
    3.6 Allergan Plc
        3.6.1 Company Profile
        3.6.2 Main Business/Business Overview
        3.6.3 Products, Services and Solutions
        3.6.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.6.5 Recent Developments
    3.7 Nektar Therapeutics
        3.7.1 Company Profile
        3.7.2 Main Business/Business Overview
        3.7.3 Products, Services and Solutions
        3.7.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.7.5 Recent Developments
    3.8 Purdue Pharma
        3.8.1 Company Profile
        3.8.2 Main Business/Business Overview
        3.8.3 Products, Services and Solutions
        3.8.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.8.5 Recent Developments
    3.9 S.L.A. Pharma AG
        3.9.1 Company Profile
        3.9.2 Main Business/Business Overview
        3.9.3 Products, Services and Solutions
        3.9.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.9.5 Recent Developments
    3.10 Mundipharma International Limited
        3.10.1 Company Profile
        3.10.2 Main Business/Business Overview
        3.10.3 Products, Services and Solutions
        3.10.4 Opioid Induced Constipation Drugs Revenue (Million USD) (2013-2018)
        3.10.5 Recent Developments
    3.11 Ono Pharmaceutical Co., Ltd
    3.12 Takeda Pharmaceutical Company Limited
    3.13 Theravance Biopharma Inc
    3.14 Valeant Pharmaceuticals International
    3.15 Cosmo Pharmaceuticals SA
    3.16 Daewoong Pharmaceutical
    3.17 C.B. Fleet Company
    3.18 Sucampo Pharmaceuticals

4 Global Opioid Induced Constipation Drugs Market Size by Type and Application (2013-2018)
    4.1 Global Opioid Induced Constipation Drugs Market Size by Type (2013-2018)
    4.2 Global Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    4.3 Potential Application of Opioid Induced Constipation Drugs in Future
    4.4 Top Consumer/End Users of Opioid Induced Constipation Drugs

5 United States Opioid Induced Constipation Drugs Development Status and Outlook
    5.1 United States Opioid Induced Constipation Drugs Market Size (2013-2018)
    5.2 United States Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    5.3 United States Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

6 EU Opioid Induced Constipation Drugs Development Status and Outlook
    6.1 EU Opioid Induced Constipation Drugs Market Size (2013-2018)
    6.2 EU Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    6.3 EU Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

7 Japan Opioid Induced Constipation Drugs Development Status and Outlook
    7.1 Japan Opioid Induced Constipation Drugs Market Size (2013-2018)
    7.2 Japan Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    7.3 Japan Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

8 China Opioid Induced Constipation Drugs Development Status and Outlook
    8.1 China Opioid Induced Constipation Drugs Market Size (2013-2018)
    8.2 China Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    8.3 China Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

9 India Opioid Induced Constipation Drugs Development Status and Outlook
    9.1 India Opioid Induced Constipation Drugs Market Size (2013-2018)
    9.2 India Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    9.3 India Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

10 Southeast Asia Opioid Induced Constipation Drugs Development Status and Outlook
    10.1 Southeast Asia Opioid Induced Constipation Drugs Market Size (2013-2018)
    10.2 Southeast Asia Opioid Induced Constipation Drugs Market Size and Market Share by Players (2013-2018)
    10.3 Southeast Asia Opioid Induced Constipation Drugs Market Size by Application (2013-2018)

11 Market Forecast by Regions, Type and Application (2018-2025)
    11.1 Global Opioid Induced Constipation Drugs Market Size (Value) by Regions (2018-2025)
        11.1.1 United States Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
        11.1.2 EU Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
        11.1.3 Japan Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
        11.1.4 China Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
        11.1.5 India Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
        11.1.6 Southeast Asia Opioid Induced Constipation Drugs Revenue and Growth Rate (2018-2025)
    11.2 Global Opioid Induced Constipation Drugs Market Size (Value) by Type (2018-2025)
    11.3 Global Opioid Induced Constipation Drugs Market Size by Application (2018-2025)

12 Opioid Induced Constipation Drugs Market Dynamics
    12.1 Opioid Induced Constipation Drugs Market Opportunities
    12.2 Opioid Induced Constipation Drugs Challenge and Risk
        12.2.1 Competition from Opponents
        12.2.2 Downside Risks of Economy
    12.3 Opioid Induced Constipation Drugs Market Constraints and Threat
        12.3.1 Threat from Substitute
        12.3.2 Government Policy
        12.3.3 Technology Risks
    12.4 Opioid Induced Constipation Drugs Market Driving Force
        12.4.1 Growing Demand from Emerging Markets
        12.4.2 Potential Application

13 Market Effect Factors Analysis
    13.1 Technology Progress/Risk
        13.1.1 Substitutes
        13.1.2 Technology Progress in Related Industry
    13.2 Consumer Needs Trend/Customer Preference
    13.3 External Environmental Change
        13.3.1 Economic Fluctuations
        13.3.2 Other Risk Factors

14 Research Finding/Conclusion

15 Appendix
    Methodology
    Analyst Introduction
    Data Source

List of Tables and Figures

    Figure Global Opioid Induced Constipation Drugs Market Size (Million USD) Status and Outlook (2013-2018)
    Table Global Opioid Induced Constipation Drugs Revenue (Million USD) Comparison by Regions (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Market Share by Regions (2013-2018)
    Figure United States Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Figure EU Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Figure Japan Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Figure China Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Figure India Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Figure Southeast Asia Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate by Regions (2013-2018)
    Table Global Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (%) Comparison by Product (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Revenue Market Share by Type in 2017
    Figure Lubiprostone Market Size (Million USD) and Growth Rate (2013-2018)
    Figure Methyl Naltrexone Bromide Market Size (Million USD) and Growth Rate (2013-2018)
    Figure Naldemedine Market Size (Million USD) and Growth Rate (2013-2018)
    Figure Alvimopan Market Size (Million USD) and Growth Rate (2013-2018)
    Figure Other Market Size (Million USD) and Growth Rate (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Market Share by Application in 2017
    Figure Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate in Hospital Pharmacies (2013-2018)
    Figure Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate in Retail Pharmacies (2013-2018)
    Figure Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate in Online Pharmacies (2013-2018)
    Table Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table Ironwood Pharmaceuticals Inc Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Ironwood Pharmaceuticals Inc (2013-2018)
    Figure Ironwood Pharmaceuticals Inc Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Daiichi Sankyo Co Ltd Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Daiichi Sankyo Co Ltd (2013-2018)
    Figure Daiichi Sankyo Co Ltd Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Pfizer Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Pfizer (2013-2018)
    Figure Pfizer Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Progenics Pharmaceuticals Inc Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Progenics Pharmaceuticals Inc (2013-2018)
    Figure Progenics Pharmaceuticals Inc Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Shionogi & Co., Ltd Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Shionogi & Co., Ltd (2013-2018)
    Figure Shionogi & Co., Ltd Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Allergan Plc Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Allergan Plc (2013-2018)
    Figure Allergan Plc Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Nektar Therapeutics Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Nektar Therapeutics (2013-2018)
    Figure Nektar Therapeutics Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Purdue Pharma Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Purdue Pharma (2013-2018)
    Figure Purdue Pharma Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table S.L.A. Pharma AG Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of S.L.A. Pharma AG (2013-2018)
    Figure S.L.A. Pharma AG Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Mundipharma International Limited Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Mundipharma International Limited (2013-2018)
    Figure Mundipharma International Limited Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Ono Pharmaceutical Co., Ltd Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Ono Pharmaceutical Co., Ltd (2013-2018)
    Figure Ono Pharmaceutical Co., Ltd Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Takeda Pharmaceutical Company Limited Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Takeda Pharmaceutical Company Limited (2013-2018)
    Figure Takeda Pharmaceutical Company Limited Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Theravance Biopharma Inc Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Theravance Biopharma Inc (2013-2018)
    Figure Theravance Biopharma Inc Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Valeant Pharmaceuticals International Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Valeant Pharmaceuticals International (2013-2018)
    Figure Valeant Pharmaceuticals International Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Cosmo Pharmaceuticals SA Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Cosmo Pharmaceuticals SA (2013-2018)
    Figure Cosmo Pharmaceuticals SA Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Daewoong Pharmaceutical Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Daewoong Pharmaceutical (2013-2018)
    Figure Daewoong Pharmaceutical Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table C.B. Fleet Company Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of C.B. Fleet Company (2013-2018)
    Figure C.B. Fleet Company Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Sucampo Pharmaceuticals Basic Information List
    Table Opioid Induced Constipation Drugs Business Revenue (Million USD) of Sucampo Pharmaceuticals (2013-2018)
    Figure Sucampo Pharmaceuticals Opioid Induced Constipation Drugs Business Revenue Market Share (2013-2018)
    Table Global Opioid Induced Constipation Drugs Market Size (Million USD) by Product (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Revenue Market Share (%) by Product (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Market Share by Product in 2017
    Table Global Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure Global Opioid Induced Constipation Drugs Revenue Market Share (%) by Application in 2017
    Table Top Consumer/End Users of Opioid Induced Constipation Drugs
    Figure United States Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table United States Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure United States Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure United States Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table United States Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure United States Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure United States Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure EU Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table EU Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure EU Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure EU Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table EU Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure EU Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure EU Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure Japan Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table Japan Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure Japan Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure Japan Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table Japan Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure Japan Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure Japan Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure China Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table China Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure China Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure China Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table China Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure China Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure China Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure India Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table India Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure India Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure India Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table India Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure India Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure India Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure Southeast Asia Opioid Induced Constipation Drugs Market Size (Million USD) and Growth Rate (2013-2018)
    Table Southeast Asia Opioid Induced Constipation Drugs Market Size (Million USD) by Players (2013-2018)
    Figure Southeast Asia Opioid Induced Constipation Drugs Market Size Share by Players in 2013
    Figure Southeast Asia Opioid Induced Constipation Drugs Market Size Share by Players in 2017
    Table Southeast Asia Opioid Induced Constipation Drugs Market Size by Application (2013-2018)
    Figure Southeast Asia Opioid Induced Constipation Drugs Revenue Market Share (%) by Application (2013-2018)
    Figure Southeast Asia Opioid Induced Constipation Drugs Market Size Share by Application in 2017
    Figure Global Opioid Induced Constipation Drugs Market Size and Growth Rate (2018-2025)
    Table Global Opioid Induced Constipation Drugs Market Size (Million USD) by Regions (2018-2025)
    Figure Global Opioid Induced Constipation Drugs Market Size Share (2018-2025)
    Figure Global Opioid Induced Constipation Drugs Market Size Share by Regions in 2025
    Figure United States Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Figure EU Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Figure Japan Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Figure China Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Figure India Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Figure Southeast Asia Opioid Induced Constipation Drugs Revenue (Million USD) and Growth Rate (2018-2025)
    Table Global Opioid Induced Constipation Drugs Market Size (Million USD) by Type (2018-2025)
    Figure Global Opioid Induced Constipation Drugs Market Size Share by Type in 2018
    Figure Global Opioid Induced Constipation Drugs Market Size Share by Type in 2025
    Table Global Opioid Induced Constipation Drugs Market Size (Million USD) by Application (2018-2025)
    Figure Global Opioid Induced Constipation Drugs Market Size (Million USD) by Application in 2018
    Figure Global Opioid Induced Constipation Drugs Market Size (Million USD) by Application in 2025