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Published: Jul, 2014 | Pages:
190 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Gastrointestinal Stromal Tumor (GIST) - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Gastrointestinal Stromal Tumor (GIST) - Pipeline Review, H2 2014', provides an overview of the Gastrointestinal Stromal Tumor (GIST)'s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Gastrointestinal Stromal Tumor (GIST), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Gastrointestinal Stromal Tumor (GIST) and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Gastrointestinal Stromal Tumor (GIST) - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Gastrointestinal Stromal Tumor (GIST) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Gastrointestinal Stromal Tumor (GIST) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Gastrointestinal Stromal Tumor (GIST) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Gastrointestinal Stromal Tumor (GIST) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Gastrointestinal Stromal Tumor (GIST) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Gastrointestinal Stromal Tumor (GIST) Overview 9 Therapeutics Development 10 Pipeline Products for Gastrointestinal Stromal Tumor (GIST) - Overview 10 Pipeline Products for Gastrointestinal Stromal Tumor (GIST) - Comparative Analysis 11 Gastrointestinal Stromal Tumor (GIST) - Therapeutics under Development by Companies 12 Gastrointestinal Stromal Tumor (GIST) - Therapeutics under Investigation by Universities/Institutes 15 Gastrointestinal Stromal Tumor (GIST) - Pipeline Products Glance 16 Late Stage Products 16 Clinical Stage Products 17 Early Stage Products 18 Gastrointestinal Stromal Tumor (GIST) - Products under Development by Companies 19 Gastrointestinal Stromal Tumor (GIST) - Products under Investigation by Universities/Institutes 20 Gastrointestinal Stromal Tumor (GIST) - Companies Involved in Therapeutics Development 21 Eli Lilly and Company 21 GlaxoSmithKline plc 22 Takeda Pharmaceutical Company Limited 23 Novartis AG 24 Astex Pharmaceuticals, Inc. 25 Bayer AG 26 Ariad Pharmaceuticals, Inc. 27 Synta Pharmaceuticals Corp. 28 Chipscreen Biosciences Ltd 29 Ambit Biosciences Corporation 30 Semafore Pharmaceuticals, Inc. 31 Deciphera Pharmaceuticals, LLC 32 AB Science 33 Gastrointestinal Stromal Tumor (GIST) - Therapeutics Assessment 34 Assessment by Monotherapy Products 34 Assessment by Combination Products 35 Assessment by Target 36 Assessment by Mechanism of Action 40 Assessment by Route of Administration 44 Assessment by Molecule Type 46 Drug Profiles 48 regorafenib - Drug Profile 48 Product Description 48 Mechanism of Action 48 R&D Progress 48 masitinib - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 nilotinib - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 masitinib - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 motesanib diphosphate - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 olaratumab - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 ponatinib - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 AT-13387 - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 ganetespib - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 dovitinib lactate - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 crenolanib besylate - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 luminespib - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 (dabrafenib + trametinib) - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 pazopanib hydrochloride - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 binimetinib - Drug Profile 89 Product Description 89 Mechanism of Action 89 R&D Progress 89 TH-302 - Drug Profile 93 Product Description 93 Mechanism of Action 93 R&D Progress 93 SF-1126 - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 CS-2164 - Drug Profile 102 Product Description 102 Mechanism of Action 102 R&D Progress 102 Vaccine Targeting NY-ESO-1 for Oncology - Drug Profile 103 Product Description 103 Mechanism of Action 103 R&D Progress 103 buparlisib hydrochloride - Drug Profile 104 Product Description 104 Mechanism of Action 104 R&D Progress 104 X-82 - Drug Profile 107 Product Description 107 Mechanism of Action 107 R&D Progress 107 quizartinib - Drug Profile 108 Product Description 108 Mechanism of Action 108 R&D Progress 108 DCC-2618 - Drug Profile 110 Product Description 110 Mechanism of Action 110 R&D Progress 110 Small Molecules Targeting c-Kit for Gastrointestinal Stromal Tumor - Drug Profile 111 Product Description 111 Mechanism of Action 111 R&D Progress 111 Gastrointestinal Stromal Tumor (GIST) - Recent Pipeline Updates 112 Gastrointestinal Stromal Tumor (GIST) - Dormant Projects 178 Gastrointestinal Stromal Tumor (GIST) - Discontinued Products 179 Gastrointestinal Stromal Tumor (GIST) - Product Development Milestones 180 Featured News & Press Releases 180 Jun 27, 2014: Regorafenib from Bayer Recommended for Approval in the European Union for the Treatment of Gastrointestinal Stromal Tumors 180 Jun 01, 2014: ARIAD Announces Initial Data from Phase 2 Trial of Ponatinib in Patients with Gastrointestinal Stromal Tumors 181 Mar 20, 2014: CHMP Adopts Negative Opinion For AB Science's Masican 182 Oct 18, 2013: Health Canada Approves A New Treatment Option For Patients With Gastrointestinal Stromal Tumours, A Rare Form Of Sarcoma 183 Oct 09, 2013: ARIAD Announces Changes in the Clinical Development Program of Iclusig 184 Sep 12, 2013: Bayer to Present Data on Regorafenib at the European Cancer Congress 2013 185 Sep 05, 2013: Bayer's Regorafenib Submitted for European Marketing Authorization for the Treatment of Gastrointestinal Stromal Tumors 186 Aug 20, 2013: Bayer's Stivarga Approved for the Treatment of Patients with Gastrointestinal Stromal Tumors in Japan 187 Jun 11, 2013: Ariad Pharma Initiates Phase II Trial Of Ponatinib In Patients With Gastrointestinal Stromal Tumors 187 Jun 04, 2013: IPAB Sets Aside Patent Revocation Order On Pfizer's Anti-Cancer Drug Sutent 188 Appendix 189 Methodology 189 Coverage 189 Secondary Research 189 Primary Research 189 Expert Panel Validation 189 Contact Us 190 Disclaimer 190
List of Tables Number of Products under Development for Gastrointestinal Stromal Tumor (GIST), H2 2014 10 Number of Products under Development for Gastrointestinal Stromal Tumor (GIST) - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Development by Companies, H2 2014 (Contd..1) 14 Number of Products under Investigation by Universities/Institutes, H2 2014 15 Comparative Analysis by Late Stage Development, H2 2014 16 Comparative Analysis by Clinical Stage Development, H2 2014 17 Comparative Analysis by Early Stage Development, H2 2014 18 Products under Development by Companies, H2 2014 19 Products under Investigation by Universities/Institutes, H2 2014 20 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Eli Lilly and Company, H2 2014 21 Gastrointestinal Stromal Tumor (GIST) - Pipeline by GlaxoSmithKline plc, H2 2014 22 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Takeda Pharmaceutical Company Limited, H2 2014 23 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Novartis AG, H2 2014 24 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Astex Pharmaceuticals, Inc., H2 2014 25 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Bayer AG, H2 2014 26 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Ariad Pharmaceuticals, Inc., H2 2014 27 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Synta Pharmaceuticals Corp., H2 2014 28 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Chipscreen Biosciences Ltd, H2 2014 29 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Ambit Biosciences Corporation, H2 2014 30 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Semafore Pharmaceuticals, Inc., H2 2014 31 Gastrointestinal Stromal Tumor (GIST) - Pipeline by Deciphera Pharmaceuticals, LLC, H2 2014 32 Gastrointestinal Stromal Tumor (GIST) - Pipeline by AB Science, H2 2014 33 Assessment by Monotherapy Products, H2 2014 34 Assessment by Combination Products, H2 2014 35 Number of Products by Stage and Target, H2 2014 38 Number of Products by Stage and Mechanism of Action, H2 2014 42 Number of Products by Stage and Route of Administration, H2 2014 45 Number of Products by Stage and Molecule Type, H2 2014 47 Gastrointestinal Stromal Tumor (GIST) Therapeutics - Recent Pipeline Updates, H2 2014 112 Gastrointestinal Stromal Tumor (GIST) - Dormant Projects, H2 2014 178 Gastrointestinal Stromal Tumor (GIST) - Discontinued Products, H2 2014 179
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