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Ewing Sarcoma - Pipeline Review, H2 2015

Published: Dec, 2015 | Pages: 159 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)

Ewing Sarcoma - Pipeline Review, H2 2015

Summary

Global Markets Direct's, 'Ewing Sarcoma - Pipeline Review, H2 2015', provides an overview of the Ewing Sarcoma's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Ewing Sarcoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Ewing Sarcoma and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- The report provides a snapshot of the global therapeutic landscape of Ewing Sarcoma
- The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities 
- The report reviews key players involved in the therapeutics development for Ewing Sarcoma and enlists all their major and minor projects
- The report summarizes all the dormant and discontinued pipeline projects 
- A review of the Ewing Sarcoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- A detailed assessment of monotherapy and combination therapy pipeline projects
- Coverage of the Ewing Sarcoma pipeline on the basis of target, MoA, route of administration and molecule type
- Latest news and deals relating related to pipeline products

Reasons to buy

- Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Develop strategic initiatives by understanding the focus areas of leading companies
- Identify and understand important and diverse types of therapeutics under development for Ewing Sarcoma
- Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
- Devise corrective measures for pipeline projects by understanding Ewing Sarcoma pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and Scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
 Table of Contents
Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Ewing Sarcoma Overview 10 Therapeutics Development 11 Pipeline Products for Ewing Sarcoma - Overview 11 Pipeline Products for Ewing Sarcoma - Comparative Analysis 12 Ewing Sarcoma - Therapeutics under Development by Companies 13 Ewing Sarcoma - Therapeutics under Investigation by Universities/Institutes 15 Ewing Sarcoma - Pipeline Products Glance 16 Clinical Stage Products 16 Early Stage Products 17 Ewing Sarcoma - Products under Development by Companies 18 Ewing Sarcoma - Products under Investigation by Universities/Institutes 19 Ewing Sarcoma - Companies Involved in Therapeutics Development 20 Cebiotex, S.L. 20 EntreChem, S.L. 21 Exelixis, Inc. 22 Gradalis Inc. 23 Kolltan Pharmaceuticals, Inc. 24 Merck & Co., Inc. 25 Merrimack Pharmaceuticals, Inc. 26 NanoSmart Pharmaceuticals, Inc. 27 Nanovalent Pharmaceuticals Inc. 28 NantKwest, Inc. 29 Novartis AG 30 Oncomatryx Biopharma, S.L. 31 Recombio S.L 32 Shionogi & Co., Ltd. 33 Sigma-Tau S.p.A. 34 Tesaro, Inc. 35 Tokalas, Inc. 36 Ewing Sarcoma - Therapeutics Assessment 37 Assessment by Monotherapy Products 37 Assessment by Target 38 Assessment by Mechanism of Action 41 Assessment by Route of Administration 43 Assessment by Molecule Type 45 Drug Profiles 47 cabozantinib s-malate - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 CEB-01 - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 celyvir - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 dactinomycin next generation - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 Dendritic Cell Therapy to Target MAGE-A1, MAGE-A3 and NY-ESO-1 for Oncology - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 Drugs to Inhibit Sirtuin 1 for Ewing Sarcoma - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 EC-8042 - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 EC-8105 - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 everolimus - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 gemogenovatucel-T - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 haNK Program - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 irinotecan hydrochloride - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 KIT-SG3227 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 Monoclonal Antibody Conjugated for Ewing Sarcoma - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 Monoclonal Antibody to Inhibit GD2 for Oncology - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 niraparib - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 NV-101 - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 OMTX-503 - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 OMTX-703 - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 pazopanib hydrochloride - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 pembrolizumab - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 racotumomab - Drug Profile 96 Product Description 96 Mechanism of Action 96 R&D Progress 96 roneparstat - Drug Profile 98 Product Description 98 Mechanism of Action 98 R&D Progress 98 S-588410 - Drug Profile 99 Product Description 99 Mechanism of Action 99 R&D Progress 99 Small Molecules for Ewing Sarcoma - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 SP-2509 - Drug Profile 101 Product Description 101 Mechanism of Action 101 R&D Progress 101 SP-2528 - Drug Profile 103 Product Description 103 Mechanism of Action 103 R&D Progress 103 SP-2577 - Drug Profile 104 Product Description 104 Mechanism of Action 104 R&D Progress 104 TK-216 - Drug Profile 105 Product Description 105 Mechanism of Action 105 R&D Progress 105 YK-4279 - Drug Profile 106 Product Description 106 Mechanism of Action 106 R&D Progress 106 Ewing Sarcoma - Recent Pipeline Updates 108 Ewing Sarcoma - Dormant Projects 152 Ewing Sarcoma - Discontinued Products 153 Ewing Sarcoma - Product Development Milestones 154 Featured News & Press Releases 154 Oct 09, 2015: Novel compound turns off mutant cancer gene in animals with leukemia 154 Jul 30, 2015: NanoSmart Receives Second FDA Orphan Drug Designation for Treatment of Pediatric Cancer 154 Jun 04, 2015: Gradalis Announces Presentation of Data from a Pilot Study of Vigil Cancer Vaccine in Ewing's Sarcoma 155 Feb 11, 2015: NanoSmart Receives FDA Orphan Drug Designation for ANA-Conjugated Liposomal Doxorubicin for the Treatment of Ewing's Sarcoma 155 Nov 26, 2012: Possible New Treatment for a Childhood Cancer 156 Apr 16, 2012: EntreChem's Mithramycin Analog EC-8042 Shows Increased Potency And High Selectivity For Treatment Of Sarcoma 157 Apr 16, 2012: EntreChem's Mithramycin Shows Increased Potency and Higher Selectivity For Treatment Of Sarcoma 157 Appendix 158 Methodology 158 Coverage 158 Secondary Research 158 Primary Research 158 Expert Panel Validation 158 Contact Us 158 Disclaimer 159
List of Tables
Number of Products under Development for Ewing Sarcoma, H2 2015 11 Number of Products under Development for Ewing Sarcoma - Comparative Analysis, H2 2015 12 Number of Products under Development by Companies, H2 2015 14 Number of Products under Investigation by Universities/Institutes, H2 2015 15 Comparative Analysis by Clinical Stage Development, H2 2015 16 Comparative Analysis by Early Stage Development, H2 2015 17 Products under Development by Companies, H2 2015 18 Products under Investigation by Universities/Institutes, H2 2015 19 Ewing Sarcoma - Pipeline by Cebiotex, S.L., H2 2015 20 Ewing Sarcoma - Pipeline by EntreChem, S.L., H2 2015 21 Ewing Sarcoma - Pipeline by Exelixis, Inc., H2 2015 22 Ewing Sarcoma - Pipeline by Gradalis Inc., H2 2015 23 Ewing Sarcoma - Pipeline by Kolltan Pharmaceuticals, Inc., H2 2015 24 Ewing Sarcoma - Pipeline by Merck & Co., Inc., H2 2015 25 Ewing Sarcoma - Pipeline by Merrimack Pharmaceuticals, Inc., H2 2015 26 Ewing Sarcoma - Pipeline by NanoSmart Pharmaceuticals, Inc., H2 2015 27 Ewing Sarcoma - Pipeline by Nanovalent Pharmaceuticals Inc., H2 2015 28 Ewing Sarcoma - Pipeline by NantKwest, Inc., H2 2015 29 Ewing Sarcoma - Pipeline by Novartis AG, H2 2015 30 Ewing Sarcoma - Pipeline by Oncomatryx Biopharma, S.L., H2 2015 31 Ewing Sarcoma - Pipeline by Recombio S.L, H2 2015 32 Ewing Sarcoma - Pipeline by Shionogi & Co., Ltd., H2 2015 33 Ewing Sarcoma - Pipeline by Sigma-Tau S.p.A., H2 2015 34 Ewing Sarcoma - Pipeline by Tesaro, Inc., H2 2015 35 Ewing Sarcoma - Pipeline by Tokalas, Inc., H2 2015 36 Assessment by Monotherapy Products, H2 2015 37 Number of Products by Stage and Target, H2 2015 39 Number of Products by Stage and Mechanism of Action, H2 2015 42 Number of Products by Stage and Route of Administration, H2 2015 44 Number of Products by Stage and Molecule Type, H2 2015 46 Ewing Sarcoma Therapeutics - Recent Pipeline Updates, H2 2015 108 Ewing Sarcoma - Dormant Projects, H2 2015 152 Ewing Sarcoma - Discontinued Products, H2 2015 153



                                

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