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Published: Mar, 2015 | Pages:
85 | Publisher: Global Markets Direct
Industry: Pharmaceuticals & Healthcare | Report Format: Electronic (PDF)
Essential Thrombocythemia - Pipeline Review, H1 2015 Summary Global Markets Direct’s, ‘Essential Thrombocythemia - Pipeline Review, H1 2015’, provides an overview of the Essential Thrombocythemia’s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Essential Thrombocythemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Essential Thrombocythemia and special features on late-stage and discontinued projects. Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Essential Thrombocythemia - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Essential Thrombocythemia and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Essential Thrombocythemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Essential Thrombocythemia pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Essential Thrombocythemia - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Essential Thrombocythemia pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 4 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Essential Thrombocythemia Overview 7 Therapeutics Development 8 Pipeline Products for Essential Thrombocythemia - Overview 8 Pipeline Products for Essential Thrombocythemia - Comparative Analysis 9 Essential Thrombocythemia - Therapeutics under Development by Companies 10 Essential Thrombocythemia - Therapeutics under Investigation by Universities/Institutes 11 Essential Thrombocythemia - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Early Stage Products 14 Essential Thrombocythemia - Products under Development by Companies 15 Essential Thrombocythemia - Products under Investigation by Universities/Institutes 16 Essential Thrombocythemia - Companies Involved in Therapeutics Development 17 Aop Orphan Pharmaceuticals AG 17 Biogenomics Limited 18 Galena Biopharma, Inc. 19 Gilead Sciences, Inc. 20 Incyte Corporation 21 Italfarmaco S.p.A. 22 Novartis AG 23 Onconova Therapeutics, Inc. 24 PharmaEssentia Corporation 25 Essential Thrombocythemia - Therapeutics Assessment 26 Assessment by Monotherapy Products 26 Assessment by Target 27 Assessment by Mechanism of Action 29 Assessment by Route of Administration 31 Assessment by Molecule Type 33 Drug Profiles 35 anagrelide hydrochloride CR - Drug Profile 35 Product Description 35 Mechanism of Action 35 R&D Progress 35 anagrelide hydrochloride PR - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 erismodegib - Drug Profile 37 Product Description 37 Mechanism of Action 37 R&D Progress 37 givinostat - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 interferon alfa-2b (recombinant) - Drug Profile 42 Product Description 42 Mechanism of Action 42 R&D Progress 42 momelotinib - Drug Profile 43 Product Description 43 Mechanism of Action 43 R&D Progress 43 peginterferon alfa-2b - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 rigosertib sodium - Drug Profile 48 Product Description 48 Mechanism of Action 48 R&D Progress 48 ruxolitinib phosphate - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 Small Molecules to Inhibit JAK for Oncology and Hematological Disorders - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 Essential Thrombocythemia - Recent Pipeline Updates 58 Essential Thrombocythemia - Dormant Projects 78 Essential Thrombocythemia - Discontinued Products 79 Essential Thrombocythemia - Product Development Milestones 80 Featured News & Press Releases 80 Nov 18, 2014: Galena Biopharma Completes Enrollment In GALE-401 (Anagrelide Controlled Release) Phase 2 Clinical Trial 80 Feb 13, 2013: Novartis's Myelofibrosis Drug Jakavi Turned Down By NICE In Draft Guidance 80 May 31, 2011: YM BioSciences Announces Orphan Drug Designation For JAK1/JAK2 Inhibitor CYT387 In Europe 81 Dec 06, 2010: Incyte Presents Positive Phase II Trial Results Of INCB18424 In Advanced Polycythemia Vera And Essential Thrombocythemia At ASH Annual Meeting 82 May 28, 2009: Incyte Provides Update on Special Protocol Assessment for INCB18424 As A New Treatment for Myelofibrosis 83 Appendix 84 Methodology 84 Coverage 84 Secondary Research 84 Primary Research 84 Expert Panel Validation 84 Contact Us 84 Disclaimer 85
List of Tables Number of Products under Development for Essential Thrombocythemia, H1 2015 8 Number of Products under Development for Essential Thrombocythemia - Comparative Analysis, H1 2015 9 Number of Products under Development by Companies, H1 2015 10 Number of Products under Investigation by Universities/Institutes, H1 2015 11 Comparative Analysis by Late Stage Development, H1 2015 12 Comparative Analysis by Clinical Stage Development, H1 2015 13 Comparative Analysis by Early Stage Development, H1 2015 14 Products under Development by Companies, H1 2015 15 Products under Investigation by Universities/Institutes, H1 2015 16 Essential Thrombocythemia - Pipeline by Aop Orphan Pharmaceuticals AG, H1 2015 17 Essential Thrombocythemia - Pipeline by Biogenomics Limited, H1 2015 18 Essential Thrombocythemia - Pipeline by Galena Biopharma, Inc., H1 2015 19 Essential Thrombocythemia - Pipeline by Gilead Sciences, Inc., H1 2015 20 Essential Thrombocythemia - Pipeline by Incyte Corporation, H1 2015 21 Essential Thrombocythemia - Pipeline by Italfarmaco S.p.A., H1 2015 22 Essential Thrombocythemia - Pipeline by Novartis AG, H1 2015 23 Essential Thrombocythemia - Pipeline by Onconova Therapeutics, Inc., H1 2015 24 Essential Thrombocythemia - Pipeline by PharmaEssentia Corporation, H1 2015 25 Assessment by Monotherapy Products, H1 2015 26 Number of Products by Stage and Target, H1 2015 28 Number of Products by Stage and Mechanism of Action, H1 2015 30 Number of Products by Stage and Route of Administration, H1 2015 32 Number of Products by Stage and Molecule Type, H1 2015 34 Essential Thrombocythemia Therapeutics - Recent Pipeline Updates, H1 2015 58 Essential Thrombocythemia - Dormant Projects, H1 2015 78 Essential Thrombocythemia - Discontinued Products, H1 2015 79
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