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Published: Jul, 2014 | Pages:
86 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Essential Thrombocythemia - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Essential Thrombocythemia - Pipeline Review, H2 2014', provides an overview of the Essential Thrombocythemia's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Essential Thrombocythemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Essential Thrombocythemia and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Essential Thrombocythemia - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Essential Thrombocythemia and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Essential Thrombocythemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Essential Thrombocythemia pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Essential Thrombocythemia - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Essential Thrombocythemia pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 4 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Essential Thrombocythemia Overview 7 Therapeutics Development 8 Pipeline Products for Essential Thrombocythemia - Overview 8 Pipeline Products for Essential Thrombocythemia - Comparative Analysis 9 Essential Thrombocythemia - Therapeutics under Development by Companies 10 Essential Thrombocythemia - Therapeutics under Investigation by Universities/Institutes 11 Essential Thrombocythemia - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Early Stage Products 14 Essential Thrombocythemia - Products under Development by Companies 15 Essential Thrombocythemia - Products under Investigation by Universities/Institutes 16 Essential Thrombocythemia - Companies Involved in Therapeutics Development 17 AstraZeneca PLC 17 Eli Lilly and Company 18 Shire Plc 19 Incyte Corporation 20 Galena Biopharma, Inc. 21 Italfarmaco S.p.A. 22 Promedior, Inc. 23 Onconova Therapeutics, Inc. 24 Pharma Mar, S.A. 25 Essential Thrombocythemia - Therapeutics Assessment 26 Assessment by Monotherapy Products 26 Assessment by Target 27 Assessment by Mechanism of Action 29 Assessment by Route of Administration 31 Assessment by Molecule Type 33 Drug Profiles 35 anagrelide hydrochloride - Drug Profile 35 Product Description 35 Mechanism of Action 35 R&D Progress 35 ruxolitinib phosphate - Drug Profile 37 Product Description 37 Mechanism of Action 37 R&D Progress 37 PRM-151 - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 plitidepsin - Drug Profile 43 Product Description 43 Mechanism of Action 43 R&D Progress 43 givinostat - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 gandotinib - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 anagrelide hydrochloride CR - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 AZD-1480 - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 rigosertib sodium - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 Small Molecules to Inhibit JAK for Oncology and Hematological Disorders - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 Essential Thrombocythemia - Recent Pipeline Updates 56 Essential Thrombocythemia - Dormant Projects 73 Essential Thrombocythemia - Discontinued Products 74 Essential Thrombocythemia - Product Development Milestones 75 Featured News & Press Releases 75 Mar 12, 2014: Geron Announces IND Clinical Hold Affecting Clinical Trials of Imetelstat in Essential Thrombocythemia and Multiple Myeloma 75 Jun 16, 2013: Geron Announces Presentation Of Updated Results From Imetelstat Phase II Trial In Essential Thrombocythemia At 18th EHA Congress 75 Feb 13, 2013: Novartis's Myelofibrosis Drug Jakavi Turned Down By NICE In Draft Guidance 77 Dec 10, 2012: Geron Presents Positive Results From Phase II Study Of Imetelstat In Essential Thrombocythemia At ASH Annual Meeting 78 May 31, 2011: YM BioSciences Announces Orphan Drug Designation For JAK1/JAK2 Inhibitor CYT387 In Europe 79 Dec 06, 2010: Incyte Presents Positive Phase II Trial Results Of INCB18424 In Advanced Polycythemia Vera And Essential Thrombocythemia At ASH Annual Meeting 80 Mar 03, 2010: Geron Gives Five Presentations On Telomerase Inhibitor Imetelstat At The AACR Annual Meeting 81 May 28, 2009: Incyte Provides Update on Special Protocol Assessment for INCB18424 As A New Treatment for Myelofibrosis 84 Apr 18, 2005: IMPAX Receives Final FDA Approval for Generic Version Of Agrylin; Third Approval in 2005 84 Apr 18, 2005: Mylan Receives Approval for Anagrelide Hydrochloride Capsules 84 Appendix 85 Methodology 85 Coverage 85 Secondary Research 85 Primary Research 85 Expert Panel Validation 85 Contact Us 86 Disclaimer 86
List of Tables Number of Products under Development for Essential Thrombocythemia, H2 2014 8 Number of Products under Development for Essential Thrombocythemia - Comparative Analysis, H2 2014 9 Number of Products under Development by Companies, H2 2014 10 Number of Products under Investigation by Universities/Institutes, H2 2014 11 Comparative Analysis by Late Stage Development, H2 2014 12 Comparative Analysis by Clinical Stage Development, H2 2014 13 Comparative Analysis by Early Stage Development, H2 2014 14 Products under Development by Companies, H2 2014 15 Products under Investigation by Universities/Institutes, H2 2014 16 Essential Thrombocythemia - Pipeline by AstraZeneca PLC, H2 2014 17 Essential Thrombocythemia - Pipeline by Eli Lilly and Company, H2 2014 18 Essential Thrombocythemia - Pipeline by Shire Plc, H2 2014 19 Essential Thrombocythemia - Pipeline by Incyte Corporation, H2 2014 20 Essential Thrombocythemia - Pipeline by Galena Biopharma, Inc., H2 2014 21 Essential Thrombocythemia - Pipeline by Italfarmaco S.p.A., H2 2014 22 Essential Thrombocythemia - Pipeline by Promedior, Inc., H2 2014 23 Essential Thrombocythemia - Pipeline by Onconova Therapeutics, Inc., H2 2014 24 Essential Thrombocythemia - Pipeline by Pharma Mar, S.A., H2 2014 25 Assessment by Monotherapy Products, H2 2014 26 Number of Products by Stage and Target, H2 2014 28 Number of Products by Stage and Mechanism of Action, H2 2014 30 Number of Products by Stage and Route of Administration, H2 2014 32 Number of Products by Stage and Molecule Type, H2 2014 34 Essential Thrombocythemia Therapeutics - Recent Pipeline Updates, H2 2014 56 Essential Thrombocythemia - Dormant Projects, H2 2014 73 Essential Thrombocythemia - Discontinued Products, H2 2014 74
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