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Published: Sep, 2014 | Pages:
117 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Endometriosis - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Endometriosis - Pipeline Review, H2 2014', provides an overview of the Endometriosis's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Endometriosis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Endometriosis and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Endometriosis - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Endometriosis and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Endometriosis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Endometriosis pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Endometriosis - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Endometriosis pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Endometriosis Overview 10 Therapeutics Development 11 Pipeline Products for Endometriosis - Overview 11 Pipeline Products for Endometriosis - Comparative Analysis 12 Endometriosis - Therapeutics under Development by Companies 13 Endometriosis - Therapeutics under Investigation by Universities/Institutes 16 Endometriosis - Pipeline Products Glance 17 Late Stage Products 17 Clinical Stage Products 18 Early Stage Products 19 Unknown Stage Products 20 Endometriosis - Products under Development by Companies 21 Endometriosis - Products under Investigation by Universities/Institutes 22 Endometriosis - Companies Involved in Therapeutics Development 23 Euroscreen S.A. 23 Takeda Pharmaceutical Company Limited 24 Neurocrine Biosciences, Inc. 25 Astellas Pharma Inc. 26 Kissei Pharmaceutical Co., Ltd. 27 SK Chemicals Co., Ltd. 28 Bayer AG 29 Addex Therapeutics Ltd 30 Evotec AG 31 ValiRx Plc 32 Repros Therapeutics Inc. 33 Dongkook Pharmaceutical Co., Ltd. 34 Lipicard Technologies Limited 35 Orphagen Pharmaceuticals, Inc. 36 Peptron, Inc. 37 PregLem SA 38 EndoCeutics, Inc. 39 Isifer AB 40 ElexoPharm GmbH 41 APAvadis Biotechnologies Srl 42 AbbVie Inc. 43 Forendo Pharma Oy 44 Endometriosis - Therapeutics Assessment 45 Assessment by Monotherapy Products 45 Assessment by Combination Products 46 Assessment by Target 47 Assessment by Mechanism of Action 50 Assessment by Route of Administration 53 Assessment by Molecule Type 55 Drug Profiles 57 elagolix sodium - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 leuprolide acetate SR - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 (acolbifene hydrochloride + GnRH agonist + prasterone) - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 relugolix - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 telapristone acetate - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 PGL-2001 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 KLH-2109 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 ASP-1707 - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 Endole - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 bentamapimod - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 ESN-364 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 BAY-1026153 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 NCE-403 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 ADX-68692 - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 SR-16234 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 VAL-201 - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 Small Molecule to Antagonize GnRH for Endometriosis, Uterine Fibroids, and Oncology - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 Small Molecules to Inhibit 17 Beta-HSD1 for Endometriosis - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 Drugs for Endometriosis - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 Peptides to Inhibit Aminopeptidase A for Cancer and Endometriosis - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 Peptides for Cancer and Endometriosis - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 EVE-104 - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 triptorelin pamoate biosimilar - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 goserelin biosimilar - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 LT-6121 - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 Synthetic Peptide to Target GPR54 for Womens Health, Male Health and Oncology - Drug Profile 86 Product Description 86 Mechanism of Action 86 R&D Progress 86 Recombinant Protein for Endometriosis and Ovarian Hyperstimulation Syndrome - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 VPE-001 - Drug Profile 88 Product Description 88 Mechanism of Action 88 R&D Progress 88 Small Molecules to Inhibit 17Beta-Hydroxysteroid Dehydrogenase Type1 for Endometriosis and Estrogen Dependent Cancers - Drug Profile 89 Product Description 89 Mechanism of Action 89 R&D Progress 89 Drug to Target RERG for Endometriosis - Drug Profile 91 Product Description 91 Mechanism of Action 91 R&D Progress 91 Small Molecules to Antagonize Prostanoid EP2 and EP4 Receptors for Endometriosis - Drug Profile 92 Product Description 92 Mechanism of Action 92 R&D Progress 92 Small Molecules to Antagonize Steroidogenic Factor-1 - Drug Profile 93 Product Description 93 Mechanism of Action 93 R&D Progress 93 Small Molecules to Inhibit CD147 for Immunology, Oncology, Womens Health and Musculoskeletal Disorders - Drug Profile 94 Product Description 94 Mechanism of Action 94 R&D Progress 94 Small Molecule To Inhibit 17 Beta-Hydroxysteroid Dehydrogenase Type 1 - Drug Profile 95 Product Description 95 Mechanism of Action 95 R&D Progress 95 Drug to Inhibit C-Jun for Endometriosis - Drug Profile 96 Product Description 96 Mechanism of Action 96 R&D Progress 96 Drugs for Gynecological Disorders - Drug Profile 97 Product Description 97 Mechanism of Action 97 R&D Progress 97 Endometriosis - Recent Pipeline Updates 98 Endometriosis - Dormant Projects 109 Endometriosis - Discontinued Products 110 Endometriosis - Product Development Milestones 111 Featured News & Press Releases 111 Apr 01, 2014: ValiRx Provides Updated On Anti-cancer Therapeutic VAL201 111 Mar 13, 2014: New drug candidate showed efficacy in human endometriosis samples 111 Oct 03, 2013: ValiRx Files Phase IB/dose escalation study for VAL201 111 Aug 29, 2013: Neurocrine Biosciences Announces the Start of Second Phase III Study of Elagolix in Endometriosis 112 Apr 25, 2013: ValiRx Receives Australian Patent For VAL201 113 Nov 13, 2012: Repros Presents Proellex Clinical Updates At Lazard Capital Markets 9th Annual Healthcare Conference 113 Oct 08, 2012: Repros Therapeutics's Proellex Receives FDA Acceptance For Reclassification Of Clinical Hold Status 113 Aug 27, 2012: FDA Provides Recommendations For Phase II Protocol For Repros' Proellex In Treatment Of Endometriosis 114 Jul 30, 2012: FDA Schedules Meeting With Repros To Discuss Phase II Protocol For Proellex For Treatment Of Endometriosis 115 Jul 16, 2012: FDA Provides Guidance To Repros For Conducting Phase II Study Of Proellex In Treatment Of Endometriosis 115 Appendix 116 Methodology 116 Coverage 116 Secondary Research 116 Primary Research 116 Expert Panel Validation 116 Contact Us 117 Disclaimer 117
List of Tables Number of Products under Development for Endometriosis, H2 2014 11 Number of Products under Development for Endometriosis - Comparative Analysis, H2 2014 12 Number of Products under Development by Companies, H2 2014 14 Number of Products under Development by Companies, H2 2014 (Contd..1) 15 Number of Products under Investigation by Universities/Institutes, H2 2014 16 Comparative Analysis by Late Stage Development, H2 2014 17 Comparative Analysis by Clinical Stage Development, H2 2014 18 Comparative Analysis by Early Stage Development, H2 2014 19 Comparative Analysis by Unknown Stage Development, H2 2014 20 Products under Development by Companies, H2 2014 21 Products under Investigation by Universities/Institutes, H2 2014 22 Endometriosis - Pipeline by Euroscreen S.A., H2 2014 23 Endometriosis - Pipeline by Takeda Pharmaceutical Company Limited, H2 2014 24 Endometriosis - Pipeline by Neurocrine Biosciences, Inc., H2 2014 25 Endometriosis - Pipeline by Astellas Pharma Inc., H2 2014 26 Endometriosis - Pipeline by Kissei Pharmaceutical Co., Ltd., H2 2014 27 Endometriosis - Pipeline by SK Chemicals Co., Ltd., H2 2014 28 Endometriosis - Pipeline by Bayer AG, H2 2014 29 Endometriosis - Pipeline by Addex Therapeutics Ltd, H2 2014 30 Endometriosis - Pipeline by Evotec AG, H2 2014 31 Endometriosis - Pipeline by ValiRx Plc, H2 2014 32 Endometriosis - Pipeline by Repros Therapeutics Inc., H2 2014 33 Endometriosis - Pipeline by Dongkook Pharmaceutical Co., Ltd., H2 2014 34 Endometriosis - Pipeline by Lipicard Technologies Limited, H2 2014 35 Endometriosis - Pipeline by Orphagen Pharmaceuticals, Inc., H2 2014 36 Endometriosis - Pipeline by Peptron, Inc., H2 2014 37 Endometriosis - Pipeline by PregLem SA, H2 2014 38 Endometriosis - Pipeline by EndoCeutics, Inc., H2 2014 39 Endometriosis - Pipeline by Isifer AB, H2 2014 40 Endometriosis - Pipeline by ElexoPharm GmbH, H2 2014 41 Endometriosis - Pipeline by APAvadis Biotechnologies Srl, H2 2014 42 Endometriosis - Pipeline by AbbVie Inc., H2 2014 43 Endometriosis - Pipeline by Forendo Pharma Oy, H2 2014 44 Assessment by Monotherapy Products, H2 2014 45 Assessment by Combination Products, H2 2014 46 Number of Products by Stage and Target, H2 2014 49 Number of Products by Stage and Mechanism of Action, H2 2014 52 Number of Products by Stage and Route of Administration, H2 2014 54 Number of Products by Stage and Molecule Type, H2 2014 56 Endometriosis Therapeutics - Recent Pipeline Updates, H2 2014 98 Endometriosis - Dormant Projects, H2 2014 109 Endometriosis - Discontinued Products, H2 2014 110
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