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Published: Aug, 2014 | Pages:
102 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Dyskinesia - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Dyskinesia - Pipeline Review, H2 2014', provides an overview of the Dyskinesia's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Dyskinesia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Dyskinesia and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Dyskinesia - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Dyskinesia and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Dyskinesia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Dyskinesia pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Dyskinesia - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Dyskinesia pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Dyskinesia Overview 9 Therapeutics Development 10 Pipeline Products for Dyskinesia - Overview 10 Pipeline Products for Dyskinesia - Comparative Analysis 11 Dyskinesia - Therapeutics under Development by Companies 12 Dyskinesia - Pipeline Products Glance 14 Late Stage Products 14 Clinical Stage Products 15 Early Stage Products 16 Dyskinesia - Products under Development by Companies 17 Dyskinesia - Companies Involved in Therapeutics Development 18 XenoPort, Inc. 18 Novartis AG 19 BioMarin Pharmaceutical Inc. 20 Addex Therapeutics Ltd 21 Avanir Pharmaceuticals, Inc. 22 Catalyst Pharmaceutical Partners, Inc. 23 Neurim Pharmaceuticals Ltd 24 Santhera Pharmaceuticals Holding AG 25 Upsher-Smith Laboratories, Inc. 26 Osmotica Pharmaceutical Corp. 27 Adamas Pharmaceuticals, Inc. 28 Targacept, Inc. 29 Heptares Therapeutics Ltd. 30 Amarantus Bioscience Holdings, Inc. 31 SciFluor Life Sciences, LLC 32 SK Biopharmaceuticals Co., Ltd. 33 Merz Pharmaceuticals GmbH 34 Neurolixis Inc. 35 Contera Pharma ApS 36 Dyskinesia - Therapeutics Assessment 37 Assessment by Monotherapy Products 37 Assessment by Combination Products 38 Assessment by Target 39 Assessment by Mechanism of Action 42 Assessment by Route of Administration 45 Assessment by Molecule Type 46 Drug Profiles 47 amantadine hydrochloride ER - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 amantadine hydrochloride ER - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 AQW-051 - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 dipraglurant IR - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 eltoprazine - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 fipamezole - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 (dextromethorphan hydrobromide + quinidine sulfate) - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 AVP-786 - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 JM-010 - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 Neu-120 - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 SKL-PD - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 naluzotan - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 CPP-115 - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 Small Molecule Targeting mGluR5 - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 acamprosate Prodrug - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 Neu-240 - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 befiradol - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 MRZ-8676 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 RGFP-109 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 TC-8831 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 IRL-790 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 Small Molecule for Dyskinesia and Hyperkinesia - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 Small Molecule For Dyskinesia - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 Small Molecules to Antagonize Metabotropic Glutamate Receptor 5 (mGluR5) for Dyskinesia - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 Dyskinesia - Recent Pipeline Updates 77 Dyskinesia - Dormant Projects 92 Dyskinesia - Discontinued Products 93 Dyskinesia - Product Development Milestones 94 Featured News & Press Releases 94 Jun 11, 2014: Neurocrine Biosciences Presenting NBI-98854 Scientific Abstracts And Posters At The International Parkinson And Movement Disorder Society's 18th Annual Congress 94 Jun 10, 2014: Adamas Pharmaceuticals Announces Rater Training Data on ADS-5102 for Parkinson's Disease Patients with Levodopa-Induced Dyskinesia 94 Jun 09, 2014: United States Patent Issued To Adamas Pharmaceuticals 95 Apr 30, 2014: Adamas Pharmaceuticals Provides Data Update On ADS-5102 At The American Academy Of Neurology Annual Meeting 96 Apr 23, 2014: Adamas Pharmaceuticals Announces Data Update At American Academy Of Neurology Annual Meeting 97 Mar 19, 2014: Santhera Receives US Patent for Fipamezole in the Treatment of Neurodegenerative Diseases 97 Oct 22, 2013: Avanir Pharmaceuticals Announces Enrollment of First Patient in Study of AVP-923 for the Treatment of Levodopa Induced Dyskinesia in Parkinson's Disease 98 Oct 02, 2013: Adamas Pharmaceuticals Presents Positive Clinical Data For ADS-5102, A Treatment For Levodopa-Induced Dyskinesia, At The World Parkinson's Congress 98 Sep 06, 2013: Avanir Pharmaceuticals Announces Settlement of NUEDEXTA Patent Litigation with Wockhardt 100 Sep 03, 2013: Avanir Pharmaceuticals Announces Settlement of NUEDEXTA Patent Litigation with Actavis 100 Appendix 101 Methodology 101 Coverage 101 Secondary Research 101 Primary Research 101 Expert Panel Validation 101 Contact Us 102 Disclaimer 102
List of Tables Number of Products under Development for Dyskinesia, H2 2014 10 Number of Products under Development for Dyskinesia - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Comparative Analysis by Late Stage Development, H2 2014 14 Comparative Analysis by Clinical Stage Development, H2 2014 15 Comparative Analysis by Early Stage Development, H2 2014 16 Products under Development by Companies, H2 2014 17 Dyskinesia - Pipeline by XenoPort, Inc., H2 2014 18 Dyskinesia - Pipeline by Novartis AG, H2 2014 19 Dyskinesia - Pipeline by BioMarin Pharmaceutical Inc., H2 2014 20 Dyskinesia - Pipeline by Addex Therapeutics Ltd, H2 2014 21 Dyskinesia - Pipeline by Avanir Pharmaceuticals, Inc., H2 2014 22 Dyskinesia - Pipeline by Catalyst Pharmaceutical Partners, Inc., H2 2014 23 Dyskinesia - Pipeline by Neurim Pharmaceuticals Ltd, H2 2014 24 Dyskinesia - Pipeline by Santhera Pharmaceuticals Holding AG, H2 2014 25 Dyskinesia - Pipeline by Upsher-Smith Laboratories, Inc., H2 2014 26 Dyskinesia - Pipeline by Osmotica Pharmaceutical Corp., H2 2014 27 Dyskinesia - Pipeline by Adamas Pharmaceuticals, Inc., H2 2014 28 Dyskinesia - Pipeline by Targacept, Inc., H2 2014 29 Dyskinesia - Pipeline by Heptares Therapeutics Ltd., H2 2014 30 Dyskinesia - Pipeline by Amarantus Bioscience Holdings, Inc., H2 2014 31 Dyskinesia - Pipeline by SciFluor Life Sciences, LLC, H2 2014 32 Dyskinesia - Pipeline by SK Biopharmaceuticals Co., Ltd., H2 2014 33 Dyskinesia - Pipeline by Merz Pharmaceuticals GmbH, H2 2014 34 Dyskinesia - Pipeline by Neurolixis Inc., H2 2014 35 Dyskinesia - Pipeline by Contera Pharma ApS, H2 2014 36 Assessment by Monotherapy Products, H2 2014 37 Assessment by Combination Products, H2 2014 38 Number of Products by Stage and Target, H2 2014 41 Number of Products by Stage and Mechanism of Action, H2 2014 44 Number of Products by Stage and Route of Administration, H2 2014 45 Number of Products by Stage and Molecule Type, H2 2014 46 Dyskinesia Therapeutics - Recent Pipeline Updates, H2 2014 77 Dyskinesia - Dormant Projects, H2 2014 92 Dyskinesia - Discontinued Products, H2 2014 93
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