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Published: Aug, 2014 | Pages:
102 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Constipation - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Constipation - Pipeline Review, H2 2014', provides an overview of the Constipation's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Constipation, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Constipation and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Constipation - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Constipation and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Constipation products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Constipation pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Constipation - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Constipation pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 6 Introduction 7 Global Markets Direct Report Coverage 7 Constipation Overview 8 Therapeutics Development 9 Pipeline Products for Constipation - Overview 9 Pipeline Products for Constipation - Comparative Analysis 10 Constipation - Therapeutics under Development by Companies 11 Constipation - Therapeutics under Investigation by Universities/Institutes 14 Constipation - Pipeline Products Glance 15 Late Stage Products 15 Clinical Stage Products 16 Early Stage Products 17 Unknown Stage Products 18 Constipation - Products under Development by Companies 19 Constipation - Products under Investigation by Universities/Institutes 20 Constipation - Companies Involved in Therapeutics Development 21 AstraZeneca PLC 21 Daiichi Sankyo Company, Limited 22 Sumitomo Dainippon Pharma Co., Ltd. 23 Astellas Pharma Inc. 24 Kissei Pharmaceutical Co., Ltd. 25 Teva Pharmaceutical Industries Limited 26 Shire Plc 27 AlbireoPharma 28 Sanwa Kagaku Kenkyusho Co., Ltd. 29 Sucampo Pharmaceuticals, Inc. 30 Ironwood Pharmaceuticals, Inc. 31 Synergy Pharmaceuticals, Inc. 32 Braintree Laboratories, Inc. 33 Beech Tree Labs, Inc. 34 Rhythm Pharmaceuticals 35 SK Biopharmaceuticals Co., Ltd. 36 Dong-A Socio Group 37 Constipation - Therapeutics Assessment 38 Assessment by Monotherapy Products 38 Assessment by Target 39 Assessment by Mechanism of Action 41 nnnnAssessment by Route of Administration 42 Assessment by Route of Administration 43 Assessment by Molecule Type 45 Drug Profiles 47 prucalopride succinate - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 linaclotide - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 lubiprostone - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 plecanatide - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 elobixibat - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 tenapanor - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 LP-101 - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 relamorelin - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 YKP-GI - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 BLI-801 - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 DSP-6952 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 KWA-0711 - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 STD-07 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 DA-6886 - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 DS-3801 - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 MDT-006 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 Small Molecule for Chronic Constipation - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 ASP-7663 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 5-BOIP - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 Transilon - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 SK-1202 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 Constipation - Recent Pipeline Updates 76 Constipation - Dormant Projects 93 Constipation - Product Development Milestones 94 Featured News & Press Releases 94 Jul 14, 2014: Synergy Pharmaceuticals Reaches Halfway Mark for the First Pivotal Phase 3 Trial of Plecanatide in Patients with Chronic Idiopathic Constipation 94 May 06, 2014: Rhythm Presents Positive GI Motility Results for Relamorelin (RM-131) in Phase 2 Chronic Constipation Study 94 May 01, 2014: Sucampo Announces Clinical Data on Lubiprostone to be Presented at Two Upcoming Scientific Conferences 95 Apr 28, 2014: Synergy Pharmaceuticals Initiates Second Phase 3 Clinical Trial of Plecanatide in Patients with Chronic Idiopathic Constipation 96 Apr 25, 2014: Sucampo Pharma To Present Preclinical Data For Lubiprostone at Experimental Biology Conference 2014 96 Mar 14, 2014: Sucampo and Takeda Announce Update on Liquid Formulation Program for AMITIZA (lubiprostone) 97 Feb 06, 2014: All Physicians in Switzerland Are Now Able to Prescribe Sucampo's AMITIZA for Chronic Idiopathic Constipation 97 Dec 17, 2013: Sucampo and Takeda Initiate Global Pivotal Phase 3 Program of Lubiprostone in Pediatric Functional Constipation 98 Nov 13, 2013: Synergy Pharmaceuticals Initiates First Phase 3 Clinical Trial of Plecanatide in Patients with Chronic Idiopathic Constipation 99 Oct 23, 2013: Sucampo and Takeda Initiate Pivotal Trial of Lubiprostone Liquid Formulation in Adults With Chronic Idiopathic Constipation 100 Appendix 101 Methodology 101 Coverage 101 Secondary Research 101 Primary Research 101 Expert Panel Validation 101 Contact Us 102 Disclaimer 102
List of Tables Number of Products under Development for Constipation, H2 2014 9 Number of Products under Development for Constipation - Comparative Analysis, H2 2014 10 Number of Products under Development by Companies, H2 2014 12 Number of Products under Development by Companies, H2 2014 (Contd..1) 13 Number of Products under Investigation by Universities/Institutes, H2 2014 14 Comparative Analysis by Late Stage Development, H2 2014 15 Comparative Analysis by Clinical Stage Development, H2 2014 16 Comparative Analysis by Early Stage Development, H2 2014 17 Comparative Analysis by Unknown Stage Development, H2 2014 18 Products under Development by Companies, H2 2014 19 Products under Investigation by Universities/Institutes, H2 2014 20 Constipation - Pipeline by AstraZeneca PLC, H2 2014 21 Constipation - Pipeline by Daiichi Sankyo Company, Limited, H2 2014 22 Constipation - Pipeline by Sumitomo Dainippon Pharma Co., Ltd., H2 2014 23 Constipation - Pipeline by Astellas Pharma Inc., H2 2014 24 Constipation - Pipeline by Kissei Pharmaceutical Co., Ltd., H2 2014 25 Constipation - Pipeline by Teva Pharmaceutical Industries Limited, H2 2014 26 Constipation - Pipeline by Shire Plc, H2 2014 27 Constipation - Pipeline by AlbireoPharma, H2 2014 28 Constipation - Pipeline by Sanwa Kagaku Kenkyusho Co., Ltd., H2 2014 29 Constipation - Pipeline by Sucampo Pharmaceuticals, Inc., H2 2014 30 Constipation - Pipeline by Ironwood Pharmaceuticals, Inc., H2 2014 31 Constipation - Pipeline by Synergy Pharmaceuticals, Inc., H2 2014 32 Constipation - Pipeline by Braintree Laboratories, Inc., H2 2014 33 Constipation - Pipeline by Beech Tree Labs, Inc., H2 2014 34 Constipation - Pipeline by Rhythm Pharmaceuticals, H2 2014 35 Constipation - Pipeline by SK Biopharmaceuticals Co., Ltd., H2 2014 36 Constipation - Pipeline by Dong-A Socio Group, H2 2014 37 Assessment by Monotherapy Products, H2 2014 38 Number of Products by Stage and Target, H2 2014 40 Number of Products by Stage and Mechanism of Action, H2 2014 42 Number of Products by Stage and Route of Administration, H2 2014 44 Number of Products by Stage and Molecule Type, H2 2014 46 Constipation Therapeutics - Recent Pipeline Updates, H2 2014 76 Constipation - Dormant Projects, H2 2014 93
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