C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Pipeline Review, H2 2016

 Table of Contents

Table of Contents 2
List of Tables 4
List of Figures 4
Introduction 5
Global Markets Direct Report Coverage 5
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) Overview 6
Therapeutics Development 7
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Products under Development by Stage of Development 7
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Products under Development by Therapy Area 8
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Products under Development by Indication 9
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Pipeline Products Glance 10
Late Stage Products 10
Early Stage Products 11
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Products under Development by Companies 12
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Products under Development by Universities/Institutes 14
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Therapeutics Assessment 16
Assessment by Monotherapy/Combination Products 16
Assessment by Mechanism of Action 17
Assessment by Route of Administration 19
Assessment by Molecule Type 20
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Companies Involved in Therapeutics Development 22
AFFiRiS AG 22
ChemoCentryx, Inc. 23
Dompe Farmaceutici S.p.A. 24
Prommune, Inc. 25
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Drug Profiles 26
avacopan - Drug Profile 26
Product Description 26
Mechanism Of Action 26
R&D Progress 26
DF-2593A - Drug Profile 31
Product Description 31
Mechanism Of Action 31
R&D Progress 31
Drug to Antagonize C5aR for Periodontitis - Drug Profile 32
Product Description 32
Mechanism Of Action 32
R&D Progress 32
EP-67 - Drug Profile 33
Product Description 33
Mechanism Of Action 33
R&D Progress 33
Small Molecule to Target C5aR for Undisclosed Indication - Drug Profile 34
Product Description 34
Mechanism Of Action 34
R&D Progress 34
Synthetic Peptide to Antagonize C5aR for Amyotrophic Lateral Sclerosis - Drug Profile 35
Product Description 35
Mechanism Of Action 35
R&D Progress 35
Vaccine to Target C5a for Alzheimer's Disease - Drug Profile 36
Product Description 36
Mechanism Of Action 36
R&D Progress 36
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Dormant Projects 37
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Discontinued Products 39
C5a Anaphylatoxin Chemotactic Receptor 1 (CD88 or C5AR1) - Featured News & Press Releases 40
Jul 13, 2016: UNMC Researcher Secures $2.25 Million Grant to Fight Antibiotic Resistance 40
Jun 16, 2016: ChemoCentryx Announces Positive Top-Line Results for CCX168 from the Phase II ANCA-Associated Vasculitis CLASSIC Study and Advances Plans to Initiate Phase III Development 40
Jun 01, 2016: ChemoCentryx Receives European Medicines Agency Priority Medicines (PRIME) Designation for Accelerated Assessment of Complement 5a Receptor Inhibitor CCX168 for Treatment of Patients with ANCA-Associated Vasculitis 42
May 23, 2016: ChemoCentryx Announces Presentation of Positive Results from Phase II ANCA-Associated Vasculitis CLEAR Trial of Orally Administered Complement 5a Receptor Inhibitor CCX168 at the 53rd ERA-EDTA Congress 43
Apr 28, 2016: ChemoCentryx Receives FDA Orphan Products Development Grant for Orally Administered Complement 5a Receptor Inhibitor CCX168 for Treatment of ANCA-Associated Vasculitis 45
Jan 06, 2016: ChemoCentryx Announces Positive Results in Phase II ANCA-Associated Vasculitis CLEAR Trial of Orally Administered Complement 5a Receptor Inhibitor CCX168 46
Nov 05, 2015: ChemoCentryx Presents Phase II Results on CCX168 at the American Society of Nephrology Annual Meeting 47
Aug 19, 2015: UNMC spinoff company to test H1N1 vaccine in animal trial 48
Dec 04, 2014: ChemoCentryx Granted EU Orphan Drug Designation for CCX168, an Orally Administered Complement C5a Receptor Inhibitor, for the Treatment of Microscopic Polyangiitis and Granulomatosis With Polyangiitis, Two Forms of ANCA-Associated Vasculitis 49
Nov 20, 2014: ChemoCentryx's CCX168, an Orally Administered Complement C5a Receptor Inhibitor, Granted Orphan-Drug Designation in Atypical Hemolytic Uremic Syndrome Treatment by the FDA 49
Nov 17, 2014: ChemoCentryx's Orally Administered C5aR Inhibitor CCX168 Shows Benefit In Non-Renal ANCA Vasculitis Disease Activity, In Addition To Previously Shown Kidney Disease Improvements 50
Jun 03, 2014: ChemoCentryx's CCX168, an Orally Administered Complement C5a Receptor Inhibitor, Granted Orphan-Drug Designation in ANCA-Associated Diseases by the FDA 51
Jun 02, 2014: ChemoCentryx's Orally-Administered Complement 5a Receptor Inhibitor, CCX168, Shows Benefit in ANCA-Associated Vasculitis Based on Birmingham Vasculitis Activity Score and Renal Disease Measurements 51
Dec 03, 2013: ChemoCentryx Announces Positive Top-Line CCX168 Phase II Data in ANCA-Associated Renal Vasculitis 52
Dec 07, 2012: Penn-Led Research Suggests A New Strategy To Prevent Or Halt Periodontal Disease 54
Appendix 56
Methodology 56
Coverage 56
Secondary Research 56
Primary Research 56
Expert Panel Validation 56
Contact Us 56
Disclaimer 57

List of Tables

Number of Products under Development for, H2 2016 7
Number of Products under Development by Therapy Area, H2 2016 8
Number of Products under Development by Indication, H2 2016 9
Comparative Analysis by Late Stage Development, H2 2016 10
Comparative Analysis by Early Stage Products, H2 2016 11
Number of Products under Development by Companies, H2 2016 12
Products under Development by Companies, H2 2016 13
Number of Products under Investigation by Universities/Institutes, H2 2016 14
Products under Investigation by Universities/Institutes, H2 2016 15
Assessment by Monotherapy/Combination Products, H2 2016 16
Number of Products by Stage and Mechanism of Action, H2 2016 18
Number of Products by Stage and Route of Administration, H2 2016 19
Number of Products by Stage and Molecule Type, H2 2016 21
Pipeline by AFFiRiS AG, H2 2016 22
Pipeline by ChemoCentryx, Inc., H2 2016 23
Pipeline by Dompe Farmaceutici S.p.A., H2 2016 24
Pipeline by Prommune, Inc., H2 2016 25
Dormant Projects, H2 2016 37
Dormant Projects (Contd..1), H2 2016 38
Discontinued Products, H2 2016 39 

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