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Published: Sep, 2014 | Pages:
118 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Bone Metastasis - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Bone Metastasis - Pipeline Review, H2 2014', provides an overview of the Bone Metastasis's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Bone Metastasis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Bone Metastasis and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Bone Metastasis - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Bone Metastasis and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Bone Metastasis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Bone Metastasis pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Bone Metastasis - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Bone Metastasis pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Bone Metastasis Overview 10 Therapeutics Development 11 Pipeline Products for Bone Metastasis - Overview 11 Pipeline Products for Bone Metastasis - Comparative Analysis 12 Bone Metastasis - Therapeutics under Development by Companies 13 Bone Metastasis - Therapeutics under Investigation by Universities/Institutes 16 Bone Metastasis - Pipeline Products Glance 17 Late Stage Products 17 Clinical Stage Products 18 Early Stage Products 19 Bone Metastasis - Products under Development by Companies 20 Bone Metastasis - Products under Investigation by Universities/Institutes 21 Bone Metastasis - Companies Involved in Therapeutics Development 22 Amgen Inc. 22 Eli Lilly and Company 23 Takeda Pharmaceutical Company Limited 24 Sigma-Tau S.p.A. 25 Bayer AG 26 Medivir AB 27 Osteologix Holdings Plc. 28 Transgene SA 29 Merrion Pharmaceuticals Plc 30 Digna Biotech, S.L. 31 Debiopharm International S.A. 32 Amura Holdings Ltd. 33 Alethia Biotherapeutics Inc. 34 Deciphera Pharmaceuticals, LLC 35 Terpenoid Therapeutics, Inc. 36 R-Pharm 37 TWi Pharmaceuticals, Inc. 38 DexTech Medical AB 39 AlphaMab Co., Ltd 40 Bone Metastasis - Therapeutics Assessment 41 Assessment by Monotherapy Products 41 Assessment by Combination Products 42 Assessment by Target 43 Assessment by Mechanism of Action 46 Assessment by Route of Administration 49 Assessment by Molecule Type 51 Drug Profiles 53 denosumab - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 zoledronic acid - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 MLN-1202 - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 radium Ra 223 dichloride - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 Osteodex - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 MIV-711 - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 RPH-203 - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 Debio-0719 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 P-17 - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 disitertide - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 MIV-710 - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 SST-0001 - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 TG-3003 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 AB-25E9 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 AM-3701 - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 DCC-2909 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 AC-301 - Drug Profile 76 Product Description 76 Mechanism of Action 76 R&D Progress 76 Recombinant Protein for Bone Metastasis and Non-Small Cell Lung Cancer - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 Vicrostatin - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 ADM-01 - Drug Profile 79 Product Description 79 Mechanism of Action 79 R&D Progress 79 LY-2109761 - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 LY-364937 - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 Drugs to Inhibit EGFR for Bone Metastasis - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 (alendronate sodium + paclitaxel + PEG) - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 alendronate sodium + HPMA + paclitaxel - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 DCC-3014 - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 Small Molecules to Inhibit GGDPS for Cancer and Bone Metastasis - Drug Profile 86 Product Description 86 Mechanism of Action 86 R&D Progress 86 TPH-9 - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 NBS-101 - Drug Profile 88 Product Description 88 Mechanism of Action 88 R&D Progress 88 Recombinant Protein to Inhibit Serine Protease for Bone Metastasis - Drug Profile 90 Product Description 90 Mechanism of Action 90 R&D Progress 90 KN-013 - Drug Profile 91 Product Description 91 Mechanism of Action 91 R&D Progress 91 Bone Metastasis - Recent Pipeline Updates 92 Bone Metastasis - Dormant Projects 107 Bone Metastasis - Discontinued Products 108 Bone Metastasis - Product Development Milestones 109 Featured News & Press Releases 109 May 23, 2014: Daiichi Sankyo Receives Approval in Japan for Additional Indication Related to RANMARK for Treatment of Giant Cell Tumor of Bone 109 Oct 09, 2013: Medivir: Positive results from a phase I study with MIV-711 for the treatment of osteoarthritis and other bone related disorders 109 Oct 01, 2013: Goodwin Biotechnology Announces the Return of AB-25E9 Monoclonal Antibody Project from Alethia Biotherapeutics 110 Jul 17, 2013: The New England Journal of Medicine publishes results from the phase III ALSYMPCA study of Xofigo 111 Jun 20, 2013: Algeta Opens Commercial Production Facility For Xofigo Injection In Kjeller, Norway 112 May 30, 2013: Algeta Announces First Sale Of Xofigo In US 113 May 22, 2013: Celsion Receives Additional Patents Covering ThermoDox Technologies 114 Feb 15, 2013: Algeta Presents Further Sub-analysis Of Phase III ALSYMPCA Study Of Radium-223 Dichloride At 2013 Genitourinary Cancers Symposium 114 Jan 14, 2013: US Nuclear Regulatory Commission Issues Licensing Decision For Radium-223 Dichloride 115 Oct 23, 2012: Amgen's Xgeva Obtains Approval From NICE For Eligibility To NHS Funding 116 Appendix 117 Methodology 117 Coverage 117 Secondary Research 117 Primary Research 117 Expert Panel Validation 117 Contact Us 118 Disclaimer 118
List of Tables Number of Products under Development for Bone Metastasis, H2 2014 11 Number of Products under Development for Bone Metastasis - Comparative Analysis, H2 2014 12 Number of Products under Development by Companies, H2 2014 14 Number of Products under Development by Companies, H2 2014 (Contd..1) 15 Number of Products under Investigation by Universities/Institutes, H2 2014 16 Comparative Analysis by Late Stage Development, H2 2014 17 Comparative Analysis by Clinical Stage Development, H2 2014 18 Comparative Analysis by Early Stage Development, H2 2014 19 Products under Development by Companies, H2 2014 20 Products under Investigation by Universities/Institutes, H2 2014 21 Bone Metastasis - Pipeline by Amgen Inc., H2 2014 22 Bone Metastasis - Pipeline by Eli Lilly and Company, H2 2014 23 Bone Metastasis - Pipeline by Takeda Pharmaceutical Company Limited, H2 2014 24 Bone Metastasis - Pipeline by Sigma-Tau S.p.A., H2 2014 25 Bone Metastasis - Pipeline by Bayer AG, H2 2014 26 Bone Metastasis - Pipeline by Medivir AB, H2 2014 27 Bone Metastasis - Pipeline by Osteologix Holdings Plc., H2 2014 28 Bone Metastasis - Pipeline by Transgene SA, H2 2014 29 Bone Metastasis - Pipeline by Merrion Pharmaceuticals Plc, H2 2014 30 Bone Metastasis - Pipeline by Digna Biotech, S.L., H2 2014 31 Bone Metastasis - Pipeline by Debiopharm International S.A., H2 2014 32 Bone Metastasis - Pipeline by Amura Holdings Ltd., H2 2014 33 Bone Metastasis - Pipeline by Alethia Biotherapeutics Inc., H2 2014 34 Bone Metastasis - Pipeline by Deciphera Pharmaceuticals, LLC, H2 2014 35 Bone Metastasis - Pipeline by Terpenoid Therapeutics, Inc., H2 2014 36 Bone Metastasis - Pipeline by R-Pharm, H2 2014 37 Bone Metastasis - Pipeline by TWi Pharmaceuticals, Inc., H2 2014 38 Bone Metastasis - Pipeline by DexTech Medical AB, H2 2014 39 Bone Metastasis - Pipeline by AlphaMab Co., Ltd, H2 2014 40 Assessment by Monotherapy Products, H2 2014 41 Assessment by Combination Products, H2 2014 42 Number of Products by Stage and Target, H2 2014 45 Number of Products by Stage and Mechanism of Action, H2 2014 48 Number of Products by Stage and Route of Administration, H2 2014 50 Number of Products by Stage and Molecule Type, H2 2014 52 Bone Metastasis Therapeutics - Recent Pipeline Updates, H2 2014 92 Bone Metastasis - Dormant Projects, H2 2014 107 Bone Metastasis - Discontinued Products, H2 2014 108
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