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Published: Sep, 2014 | Pages:
142 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H2 2014', provides an overview of the Bile Duct Cancer (Cholangiocarcinoma)'s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Bile Duct Cancer (Cholangiocarcinoma), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Bile Duct Cancer (Cholangiocarcinoma) and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Bile Duct Cancer (Cholangiocarcinoma) - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Bile Duct Cancer (Cholangiocarcinoma) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Bile Duct Cancer (Cholangiocarcinoma) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Bile Duct Cancer (Cholangiocarcinoma) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Bile Duct Cancer (Cholangiocarcinoma) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Bile Duct Cancer (Cholangiocarcinoma) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Bile Duct Cancer (Cholangiocarcinoma) Overview 9 Therapeutics Development 10 Pipeline Products for Bile Duct Cancer (Cholangiocarcinoma) - Overview 10 Pipeline Products for Bile Duct Cancer (Cholangiocarcinoma) - Comparative Analysis 11 Bile Duct Cancer (Cholangiocarcinoma) - Therapeutics under Development by Companies 12 Bile Duct Cancer (Cholangiocarcinoma) - Therapeutics under Investigation by Universities/Institutes 15 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Products Glance 16 Clinical Stage Products 16 Early Stage Products 17 Bile Duct Cancer (Cholangiocarcinoma) - Products under Development by Companies 18 Bile Duct Cancer (Cholangiocarcinoma) - Products under Investigation by Universities/Institutes 19 Bile Duct Cancer (Cholangiocarcinoma) - Companies Involved in Therapeutics Development 20 Sanofi 20 AstraZeneca PLC 21 Eli Lilly and Company 22 GlaxoSmithKline plc 23 Plexxikon Inc. 24 Panacea Pharmaceuticals, Inc. 25 Novartis AG 26 Exelixis, Inc. 27 Celgene Corporation 28 Bayer AG 29 Access Pharmaceuticals, Inc. 30 OncoTherapy Science, Inc. 31 PCI Biotech AS 32 Provecs Medical GmbH 33 Agios Pharmaceuticals, Inc. 34 Boston Biomedical, Inc. 35 Merrimack Pharmaceuticals, Inc. 36 Cornerstone Pharmaceuticals, Inc. 37 NuCana BioMed Limited 38 Arrien Pharmaceuticals, LLC 39 Senhwa Biosciences, Inc. 40 Bile Duct Cancer (Cholangiocarcinoma) - Therapeutics Assessment 41 Assessment by Monotherapy Products 41 Assessment by Target 42 Assessment by Mechanism of Action 45 Assessment by Route of Administration 48 Assessment by Molecule Type 50 Drug Profiles 52 regorafenib - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 vandetanib - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 AP-5346 - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 trametinib dimethyl sulfoxide - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 paclitaxel albumin bound - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 cabozantinib s-malate - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 elpamotide - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 BGJ-398 - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 LY-2801653 - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 BBI-503 - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 CPI-613 - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 binimetinib - Drug Profile 77 Product Description 77 Mechanism of Action 77 R&D Progress 77 silmitasertib - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 gemcitabine - Drug Profile 83 Product Description 83 Mechanism of Action 83 R&D Progress 83 PLX-8394 - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 SAR-408701 - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 seribantumab - Drug Profile 86 Product Description 86 Mechanism of Action 86 R&D Progress 86 NUC-1031 - Drug Profile 89 Product Description 89 Mechanism of Action 89 R&D Progress 89 AG-120 - Drug Profile 91 Product Description 91 Mechanism of Action 91 R&D Progress 91 Im-01 - Drug Profile 93 Product Description 93 Mechanism of Action 93 R&D Progress 93 PAN-622 - Drug Profile 94 Product Description 94 Mechanism of Action 94 R&D Progress 94 ARN-5032 - Drug Profile 95 Product Description 95 Mechanism of Action 95 R&D Progress 95 JP-1584 - Drug Profile 96 Product Description 96 Mechanism of Action 96 R&D Progress 96 Bile Duct Cancer (Cholangiocarcinoma) - Recent Pipeline Updates 97 Bile Duct Cancer (Cholangiocarcinoma) - Dormant Projects 134 Bile Duct Cancer (Cholangiocarcinoma) - Discontinued Products 135 Bile Duct Cancer (Cholangiocarcinoma) - Product Development Milestones 136 Featured News & Press Releases 136 Jul 15, 2014: CellAct Pharma Receives Orphan Drug Designation in EU for CAP7.1 in Biliary Tract Cancers 136 Jun 17, 2014: Senhwa Biosciences Initiates Phase 1/2 Trial of CX-4945 in Combination with Gemcitabine and Cisplatin 136 Mar 12, 2014: Cornerstone Pharmaceuticals Lead Compound CPI-613 Demonstrates Ability to Disrupt Growth of Cancer Cells 137 Apr 10, 2013: Lilly Reveals Data Of LY2801653 At AACR Annual Meeting 138 Aug 14, 2012: Provecs Medical Receives US Patent Covering Technology Around Immunalon 139 Jan 10, 2012: Clinical Study Confirms Benitec's Gene-silencing Technology Is Safe And Effective In Fang Vaccine 139 Apr 07, 2009: Oncolytics Biotech Inc. Announces Positive Results of U.K. Phase II REOLYSIN and Radiation Combination Clinical Trial For The Trial REO 008 140 Appendix 141 Methodology 141 Coverage 141 Secondary Research 141 Primary Research 141 Expert Panel Validation 141 Contact Us 142 Disclaimer 142
List of Tables Number of Products under Development for Bile Duct Cancer (Cholangiocarcinoma), H2 2014 10 Number of Products under Development for Bile Duct Cancer (Cholangiocarcinoma) - Comparative Analysis, H2 2014 11 Number of Products under Development by Companies, H2 2014 13 Number of Products under Development by Companies, H2 2014 (Contd..1) 14 Number of Products under Investigation by Universities/Institutes, H2 2014 15 Comparative Analysis by Clinical Stage Development, H2 2014 16 Comparative Analysis by Early Stage Development, H2 2014 17 Products under Development by Companies, H2 2014 18 Products under Investigation by Universities/Institutes, H2 2014 19 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Sanofi, H2 2014 20 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by AstraZeneca PLC, H2 2014 21 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Eli Lilly and Company, H2 2014 22 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by GlaxoSmithKline plc, H2 2014 23 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Plexxikon Inc., H2 2014 24 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Panacea Pharmaceuticals, Inc., H2 2014 25 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Novartis AG, H2 2014 26 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Exelixis, Inc., H2 2014 27 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Celgene Corporation, H2 2014 28 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Bayer AG, H2 2014 29 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Access Pharmaceuticals, Inc., H2 2014 30 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by OncoTherapy Science, Inc., H2 2014 31 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by PCI Biotech AS, H2 2014 32 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Provecs Medical GmbH, H2 2014 33 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Agios Pharmaceuticals, Inc., H2 2014 34 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Boston Biomedical, Inc., H2 2014 35 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Merrimack Pharmaceuticals, Inc., H2 2014 36 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Cornerstone Pharmaceuticals, Inc., H2 2014 37 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by NuCana BioMed Limited, H2 2014 38 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Arrien Pharmaceuticals, LLC, H2 2014 39 Bile Duct Cancer (Cholangiocarcinoma) - Pipeline by Senhwa Biosciences, Inc., H2 2014 40 Assessment by Monotherapy Products, H2 2014 41 Number of Products by Stage and Target, H2 2014 44 Number of Products by Stage and Mechanism of Action, H2 2014 47 Number of Products by Stage and Route of Administration, H2 2014 49 Number of Products by Stage and Molecule Type, H2 2014 51 Bile Duct Cancer (Cholangiocarcinoma) Therapeutics - Recent Pipeline Updates, H2 2014 97 Bile Duct Cancer (Cholangiocarcinoma) - Dormant Projects, H2 2014 134 Bile Duct Cancer (Cholangiocarcinoma) - Discontinued Products, H2 2014 135
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