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Published: Jul, 2014 | Pages:
179 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
B-Cell Non-Hodgkin Lymphoma - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'B-Cell Non-Hodgkin Lymphoma - Pipeline Review, H2 2014', provides an overview of the B-Cell Non-Hodgkin Lymphoma's therapeutic pipeline. This report provides comprehensive information on the therapeutic development for B-Cell Non-Hodgkin Lymphoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for B-Cell Non-Hodgkin Lymphoma and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of B-Cell Non-Hodgkin Lymphoma - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for B-Cell Non-Hodgkin Lymphoma and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the B-Cell Non-Hodgkin Lymphoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the B-Cell Non-Hodgkin Lymphoma pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for B-Cell Non-Hodgkin Lymphoma - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding B-Cell Non-Hodgkin Lymphoma pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 8 List of Figures 9 Introduction 10 Global Markets Direct Report Coverage 10 B-Cell Non-Hodgkin Lymphoma Overview 11 Therapeutics Development 12 Pipeline Products for B-Cell Non-Hodgkin Lymphoma - Overview 12 Pipeline Products for B-Cell Non-Hodgkin Lymphoma - Comparative Analysis 13 B-Cell Non-Hodgkin Lymphoma - Therapeutics under Development by Companies 14 B-Cell Non-Hodgkin Lymphoma - Therapeutics under Investigation by Universities/Institutes 17 B-Cell Non-Hodgkin Lymphoma - Pipeline Products Glance 18 Late Stage Products 18 Clinical Stage Products 19 Early Stage Products 20 B-Cell Non-Hodgkin Lymphoma - Products under Development by Companies 21 B-Cell Non-Hodgkin Lymphoma - Products under Investigation by Universities/Institutes 23 B-Cell Non-Hodgkin Lymphoma - Companies Involved in Therapeutics Development 24 Bristol-Myers Squibb Company 24 Boehringer Ingelheim GmbH 25 Amgen Inc. 26 Sanofi 27 Seattle Genetics, Inc. 28 Genentech, Inc. 29 MedImmune, LLC 30 Merck & Co., Inc. 31 Millennium Pharmaceuticals, Inc. 32 Biocon Limited 33 Ono Pharmaceutical Co., Ltd. 34 Sandoz Inc. 35 Celgene Corporation 36 Incyte Corporation 37 Merck KGaA 38 Immunomedics, Inc. 39 Portola Pharmaceuticals, Inc. 40 Pharmacyclics, Inc. 41 Takara Bio Inc. 42 Simcere Pharmaceutical Group 43 Spectrum Pharmaceuticals, Inc. 44 Cornerstone Pharmaceuticals, Inc. 45 LFB S.A. 46 Eagle Pharmaceuticals Inc. 47 Areta International s.r.l. 48 Molecular Templates Inc. 49 Aprogen, Inc. 50 BioMedics Japan Inc. 51 B-Cell Non-Hodgkin Lymphoma - Therapeutics Assessment 52 Assessment by Monotherapy Products 52 Assessment by Target 53 Assessment by Mechanism of Action 56 Assessment by Route of Administration 59 Assessment by Molecule Type 61 Drug Profiles 63 bendamustine hydrochloride RTD - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 bendamustine hydrochloride - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 rituximab biosimilar - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 alisertib - Drug Profile 66 Product Description 66 Mechanism of Action 66 R&D Progress 66 coltuximab ravtansine - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 pralatrexate - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 vorinostat - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 moxetumomab pasudotox - Drug Profile 78 Product Description 78 Mechanism of Action 78 R&D Progress 78 BVX-20 - Drug Profile 80 Product Description 80 Mechanism of Action 80 R&D Progress 80 DI-Leu16-IL2 - Drug Profile 81 Product Description 81 Mechanism of Action 81 R&D Progress 81 ublituximab - Drug Profile 82 Product Description 82 Mechanism of Action 82 R&D Progress 82 PRT-2070 - Drug Profile 84 Product Description 84 Mechanism of Action 84 R&D Progress 84 CD19-CAR Gene Therapy - Drug Profile 85 Product Description 85 Mechanism of Action 85 R&D Progress 85 MDX-1203 - Drug Profile 86 Product Description 86 Mechanism of Action 86 R&D Progress 86 SGN-CD19A - Drug Profile 87 Product Description 87 Mechanism of Action 87 R&D Progress 87 milatuzumab - Drug Profile 88 Product Description 88 Mechanism of Action 88 R&D Progress 88 ibrutinib - Drug Profile 90 Product Description 90 Mechanism of Action 90 R&D Progress 90 CPI-613 - Drug Profile 95 Product Description 95 Mechanism of Action 95 R&D Progress 95 CD19.CAR-CD28Z T Cells - Drug Profile 97 Product Description 97 Mechanism of Action 97 R&D Progress 97 urelumab - Drug Profile 98 Product Description 98 Mechanism of Action 98 R&D Progress 98 NSC-678515 - Drug Profile 100 Product Description 100 Mechanism of Action 100 R&D Progress 100 Cell Therapy for Chronic Lymphocytic Leukemia and B-Cell Non-Hodgkin Lymphoma - Drug Profile 101 Product Description 101 Mechanism of Action 101 R&D Progress 101 CC-292 - Drug Profile 102 Product Description 102 Mechanism of Action 102 R&D Progress 102 EMD-521873 - Drug Profile 104 Product Description 104 Mechanism of Action 104 R&D Progress 104 rituximab biosimilar - Drug Profile 105 Product Description 105 Mechanism of Action 105 R&D Progress 105 BI-836826 - Drug Profile 106 Product Description 106 Mechanism of Action 106 R&D Progress 106 AMG-319 - Drug Profile 107 Product Description 107 Mechanism of Action 107 R&D Progress 107 ONO-4059 - Drug Profile 108 Product Description 108 Mechanism of Action 108 R&D Progress 108 BM-ca - Drug Profile 109 Product Description 109 Mechanism of Action 109 R&D Progress 109 INCB-40093 - Drug Profile 110 Product Description 110 Mechanism of Action 110 R&D Progress 110 GDC-0853 - Drug Profile 111 Product Description 111 Mechanism of Action 111 R&D Progress 111 Cell Therapy for Leukemia - Drug Profile 112 Product Description 112 Mechanism of Action 112 R&D Progress 112 INCB-050465 - Drug Profile 114 Product Description 114 Mechanism of Action 114 R&D Progress 114 bendamustine hydrochloride SI - Drug Profile 115 Product Description 115 Mechanism of Action 115 R&D Progress 115 rituximab biosimilar - Drug Profile 116 Product Description 116 Mechanism of Action 116 R&D Progress 116 Recombinant Idiotypic VK3-20 Vaccine - Drug Profile 117 Product Description 117 Mechanism of Action 117 R&D Progress 117 MT-3724 - Drug Profile 118 Product Description 118 Mechanism of Action 118 R&D Progress 118 rituximab biosimilar - Drug Profile 120 Product Description 120 Mechanism of Action 120 R&D Progress 120 rituximab biosimilar - Drug Profile 121 Product Description 121 Mechanism of Action 121 R&D Progress 121 PLS-123 - Drug Profile 122 Product Description 122 Mechanism of Action 122 R&D Progress 122 SH-7133 - Drug Profile 123 Product Description 123 Mechanism of Action 123 R&D Progress 123 SH-7129 - Drug Profile 124 Product Description 124 Mechanism of Action 124 R&D Progress 124 202-b - Drug Profile 126 Product Description 126 Mechanism of Action 126 R&D Progress 126 SH-7113 - Drug Profile 128 Product Description 128 Mechanism of Action 128 R&D Progress 128 B-Cell Non-Hodgkin Lymphoma - Recent Pipeline Updates 129 B-Cell Non-Hodgkin Lymphoma - Dormant Projects 163 B-Cell Non-Hodgkin Lymphoma - Discontinued Products 164 B-Cell Non-Hodgkin Lymphoma - Product Development Milestones 165 Featured News & Press Releases 165 Jul 08, 2014: Eagle Pharmaceuticals Receives Orphan Drug Designation for Lower Volume, Shorter Infusion Time Bendamustine Hydrochloride Product for Chronic Lymphocytic Leukemia and Indolent B-Cell Non-Hodgkin's Lymphoma 165 Apr 18, 2014: Molecular Templates Presents Preclinical Data on Engineered Toxin Bodies (ETB) at the AACR Annual Meeting 165 Dec 10, 2013: Pharmacyclics Announces Data Presentations for Ibrutinib in B-Cell Malignancies 166 Sep 17, 2013: FDA Approves Teva's TREANDA Injection, a New Liquid Formulation 170 Sep 09, 2013: TG Therapeutics' Ublituximab Receives Orphan Drug Designation for the Treatment of Nodal Marginal Zone Lymphoma and Extranodal Marginal Zone Lymphoma 171 Jun 02, 2013: Infinity Pharma Reports Presentation Of Updated Phase I Data Of IPI-145 In Chronic Lymphocytic Leukemia At ASCO Annual Meeting 171 May 15, 2013: Janssen Oncology Announces Presentation Of Data On Ibrutinib At 2013 ASCO Annual Meeting 174 Feb 11, 2013: TG Therapeutics Opens Expansion Cohorts In Phase I/II Trial Of TG-1101 In Patients With Rituximab Relapsed Or Refractory B-cell Non-Hodgkin's Lymphoma 175 Feb 06, 2013: Seattle Genetics Initiates Two Phase I Trials Of SGN-CD19A 176 Dec 11, 2012: Celgene Presents Data Evaluating Combination Treatments Including Revlimid Plus Antibody Therapies In Patients With Various Forms Of Non-Hodgkin Lymphoma At ASH 2012 176 Appendix 178 Methodology 178 Coverage 178 Secondary Research 178 Primary Research 178 Expert Panel Validation 178 Contact Us 179 Disclaimer 179
List of Tables Number of Products under Development for B-Cell Non-Hodgkin Lymphoma, H2 2014 12 Number of Products under Development for B-Cell Non-Hodgkin Lymphoma - Comparative Analysis, H2 2014 13 Number of Products under Development by Companies, H2 2014 15 Number of Products under Development by Companies, H2 2014 (Contd..1) 16 Number of Products under Investigation by Universities/Institutes, H2 2014 17 Comparative Analysis by Late Stage Development, H2 2014 18 Comparative Analysis by Clinical Stage Development, H2 2014 19 Comparative Analysis by Early Stage Development, H2 2014 20 Products under Development by Companies, H2 2014 21 Products under Development by Companies, H2 2014 (Contd..1) 22 Products under Investigation by Universities/Institutes, H2 2014 23 B-Cell Non-Hodgkin Lymphoma - Pipeline by Bristol-Myers Squibb Company, H2 2014 24 B-Cell Non-Hodgkin Lymphoma - Pipeline by Boehringer Ingelheim GmbH, H2 2014 25 B-Cell Non-Hodgkin Lymphoma - Pipeline by Amgen Inc., H2 2014 26 B-Cell Non-Hodgkin Lymphoma - Pipeline by Sanofi, H2 2014 27 B-Cell Non-Hodgkin Lymphoma - Pipeline by Seattle Genetics, Inc., H2 2014 28 B-Cell Non-Hodgkin Lymphoma - Pipeline by Genentech, Inc., H2 2014 29 B-Cell Non-Hodgkin Lymphoma - Pipeline by Merck & Co., Inc., H2 2014 31 B-Cell Non-Hodgkin Lymphoma - Pipeline by Millennium Pharmaceuticals, Inc., H2 2014 32 B-Cell Non-Hodgkin Lymphoma - Pipeline by Ono Pharmaceutical Co., Ltd., H2 2014 34 B-Cell Non-Hodgkin Lymphoma - Pipeline by Sandoz Inc., H2 2014 35 B-Cell Non-Hodgkin Lymphoma - Pipeline by Celgene Corporation, H2 2014 36 B-Cell Non-Hodgkin Lymphoma - Pipeline by Incyte Corporation, H2 2014 37 B-Cell Non-Hodgkin Lymphoma - Pipeline by Merck KGaA, H2 2014 38 B-Cell Non-Hodgkin Lymphoma - Pipeline by Immunomedics, Inc., H2 2014 39 B-Cell Non-Hodgkin Lymphoma - Pipeline by Portola Pharmaceuticals, Inc., H2 2014 40 B-Cell Non-Hodgkin Lymphoma - Pipeline by Pharmacyclics, Inc., H2 2014 41 B-Cell Non-Hodgkin Lymphoma - Pipeline by Takara Bio Inc., H2 2014 42 B-Cell Non-Hodgkin Lymphoma - Pipeline by Simcere Pharmaceutical Group, H2 2014 43 B-Cell Non-Hodgkin Lymphoma - Pipeline by Spectrum Pharmaceuticals, Inc., H2 2014 44 B-Cell Non-Hodgkin Lymphoma - Pipeline by Cornerstone Pharmaceuticals, Inc., H2 2014 45 B-Cell Non-Hodgkin Lymphoma - Pipeline by LFB S.A., H2 2014 46 B-Cell Non-Hodgkin Lymphoma - Pipeline by Eagle Pharmaceuticals Inc., H2 2014 47 B-Cell Non-Hodgkin Lymphoma - Pipeline by Areta International s.r.l., H2 2014 48 B-Cell Non-Hodgkin Lymphoma - Pipeline by Molecular Templates Inc., H2 2014 49 B-Cell Non-Hodgkin Lymphoma - Pipeline by Aprogen, Inc., H2 2014 50 B-Cell Non-Hodgkin Lymphoma - Pipeline by BioMedics Japan Inc., H2 2014 51 Assessment by Monotherapy Products, H2 2014 52 Number of Products by Stage and Target, H2 2014 55 Number of Products by Stage and Mechanism of Action, H2 2014 58 Number of Products by Stage and Route of Administration, H2 2014 60 Number of Products by Stage and Molecule Type, H2 2014 62 B-Cell Non-Hodgkin Lymphoma Therapeutics - Recent Pipeline Updates, H2 2014 129 B-Cell Non-Hodgkin Lymphoma - Dormant Projects, H2 2014 163 B-Cell Non-Hodgkin Lymphoma - Discontinued Products, H2 2014 164
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