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Published: Dec, 2014 | Pages:
96 | Publisher: Global Markets Direct
Industry: Healthcare | Report Format: Electronic (PDF)
Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Review, H2 2014 Summary Global Markets Direct's, 'Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Review, H2 2014', provides an overview of the Anaplastic Large Cell Lymphoma (ALCL)'s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Anaplastic Large Cell Lymphoma (ALCL), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Anaplastic Large Cell Lymphoma (ALCL) and special features on late-stage and discontinued projects. Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Anaplastic Large Cell Lymphoma (ALCL) - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Anaplastic Large Cell Lymphoma (ALCL) and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Anaplastic Large Cell Lymphoma (ALCL) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Anaplastic Large Cell Lymphoma (ALCL) pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies - Identify and understand important and diverse types of therapeutics under development for Anaplastic Large Cell Lymphoma (ALCL) - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline - Devise corrective measures for pipeline projects by understanding Anaplastic Large Cell Lymphoma (ALCL) pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline
Table of Contents Table of Contents 2 List of Tables 5 List of Figures 6 Introduction 7 Global Markets Direct Report Coverage 7 Anaplastic Large Cell Lymphoma (ALCL) Overview 8 Therapeutics Development 9 Pipeline Products for Anaplastic Large Cell Lymphoma (ALCL) - Overview 9 Pipeline Products for Anaplastic Large Cell Lymphoma (ALCL) - Comparative Analysis 10 Anaplastic Large Cell Lymphoma (ALCL) - Therapeutics under Development by Companies 11 Anaplastic Large Cell Lymphoma (ALCL) - Therapeutics under Investigation by Universities/Institutes 12 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Products Glance 13 Late Stage Products 13 Clinical Stage Products 14 Early Stage Products 15 Anaplastic Large Cell Lymphoma (ALCL) - Products under Development by Companies 16 Anaplastic Large Cell Lymphoma (ALCL) - Products under Investigation by Universities/Institutes 17 Anaplastic Large Cell Lymphoma (ALCL) - Companies Involved in Therapeutics Development 18 Akron Molecules AG 18 AstraZeneca PLC 19 Bayer AG 20 Celon Pharma Sp. z o.o. 21 Novartis AG 22 Pfizer Inc. 23 Sareum Holdings plc 24 Seattle Genetics, Inc. 25 Sigma-Tau S.p.A. 26 Teva Pharmaceutical Industries Limited 27 Anaplastic Large Cell Lymphoma (ALCL) - Therapeutics Assessment 28 Assessment by Monotherapy Products 28 Assessment by Target 29 Assessment by Mechanism of Action 31 Assessment by Route of Administration 33 Assessment by Molecule Type 35 Drug Profiles 37 AKR-303 - Drug Profile 37 Product Description 37 Mechanism of Action 37 R&D Progress 37 AZD-3463 - Drug Profile 38 Product Description 38 Mechanism of Action 38 R&D Progress 38 brentuximab vedotin - Drug Profile 39 Product Description 39 Mechanism of Action 39 R&D Progress 39 CEP-28122 - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 CEP-37440 - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 copanlisib - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 crizotinib - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 Drug to Inhibit ALK for Anaplastic Large Cell Lymphoma - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 KRA-0008 - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 luminespib - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 pegaspargase - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 SH-7129 - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 Small Molecules to Inhibit Aurora and ALK Kinase for Oncology - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 Anaplastic Large Cell Lymphoma (ALCL) - Recent Pipeline Updates 62 Anaplastic Large Cell Lymphoma (ALCL) - Dormant Projects 79 Anaplastic Large Cell Lymphoma (ALCL) - Product Development Milestones 80 Featured News & Press Releases 80 Dec 07, 2014: Seattle Genetics and Takeda Announce Four-Year Survival Data from ADCETRIS (Brentuximab Vedotin) Pivotal Trial in Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma at ASH Annual Meeting 80 Dec 06, 2014: Seattle Genetics and Takeda Report Phase 3 AETHERA Clinical Trial Data from ADCETRIS (Brentuximab Vedotin) in Post-Transplant Hodgkin Lymphoma Patients at Risk of Relapse at ASH Annual Meeting 81 Nov 07, 2014: Seattle Genetics to Present Clinical Data from Broad ADCETRIS (Brentuximab Vedotin) Development Program and Novel Antibody-Drug Conjugates at ASH 2014 83 Nov 06, 2014: Takeda Announces Abstracts for ADCETRIS (brentuximab vedotin) in Hodgkin Lymphoma, Systemic Anaplastic Large Cell Lymphoma to be Presented at 56th American Society of Hematology Annual Meeting 85 Sep 24, 2014: Seattle Genetics Highlights Updated Progression-Free Survival and Overall Survival Data from ADCETRIS (Brentuximab Vedotin) Frontline PTCL Phase 1 Clinical Trial at the ESMO 2014 Congress 86 Apr 17, 2014: ADCETRIS 50mg for intravenous drip infusion", Treatment for Patients with CD30 Positive Relapsed or Refractory Hodgkin Lymphoma or Relapsed or Refractory Anaplastic Large Cell Lymphoma Now Available in Japan 88 Jan 17, 2014: Seattle Genetics Announces ADCETRIS Approval in Japan for the Treatment of Relapsed or Refractory Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma 88 Jun 21, 2013: Seattle Genetics Highlights Adcetris Clinical Data At International Conference On Malignant Lymphoma 89 Jun 19, 2013: Takeda And Seattle Genetics Highlight Post-Hoc Analysis Examining Progression-free Survival With Adcetris At International Conference On Malignant Lymphoma 91 Jun 01, 2013: Takeda Highlights Data From Phase I/II Clinical Trial Examining Use Of Adcetris in Pediatric Patients With Hodgkin Lymphoma Or Systemic Anaplastic Large Cell Lymphoma 93 Appendix 95 Methodology 95 Coverage 95 Secondary Research 95 Primary Research 95 Expert Panel Validation 95 Contact Us 96 Disclaimer 96
List of Tables Number of Products under Development for Anaplastic Large Cell Lymphoma (ALCL), H2 2014 9 Number of Products under Development for Anaplastic Large Cell Lymphoma (ALCL) - Comparative Analysis, H2 2014 10 Number of Products under Development by Companies, H2 2014 11 Number of Products under Investigation by Universities/Institutes, H2 2014 12 Comparative Analysis by Late Stage Development, H2 2014 13 Comparative Analysis by Clinical Stage Development, H2 2014 14 Comparative Analysis by Early Stage Development, H2 2014 15 Products under Development by Companies, H2 2014 16 Products under Investigation by Universities/Institutes, H2 2014 17 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Akron Molecules AG, H2 2014 18 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by AstraZeneca PLC, H2 2014 19 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Bayer AG, H2 2014 20 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Celon Pharma Sp. z o.o., H2 2014 21 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Novartis AG, H2 2014 22 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Pfizer Inc., H2 2014 23 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Sareum Holdings plc, H2 2014 24 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Seattle Genetics, Inc., H2 2014 25 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Sigma-Tau S.p.A., H2 2014 26 Anaplastic Large Cell Lymphoma (ALCL) - Pipeline by Teva Pharmaceutical Industries Limited, H2 2014 27 Assessment by Monotherapy Products, H2 2014 28 Number of Products by Stage and Target, H2 2014 30 Number of Products by Stage and Mechanism of Action, H2 2014 32 Number of Products by Stage and Route of Administration, H2 2014 34 Number of Products by Stage and Molecule Type, H2 2014 36 Anaplastic Large Cell Lymphoma (ALCL) Therapeutics - Recent Pipeline Updates, H2 2014 62 Anaplastic Large Cell Lymphoma (ALCL) - Dormant Projects, H2 2014 79
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